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Sesn2 sestrin 2 [ Mus musculus (house mouse) ]

Gene ID: 230784, updated on 10-Apr-2024

Summary

Official Symbol
Sesn2provided by MGI
Official Full Name
sestrin 2provided by MGI
Primary source
MGI:MGI:2651874
See related
Ensembl:ENSMUSG00000028893 AllianceGenome:MGI:2651874
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HI95; Ses2; SEST2
Summary
Enables GDP-dissociation inhibitor activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of TORC1 signaling; and negative regulation of translation in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including positive regulation of lipophagy; protein kinase B signaling; and regulation of cAMP-dependent protein kinase activity. Part of TORC2 complex and nucleotide-activated protein kinase complex. Is expressed in central nervous system and retina. Orthologous to human SESN2 (sestrin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 10.3), kidney adult (RPKM 10.2) and 28 other tissues See more
Orthologs
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Genomic context

See Sesn2 in Genome Data Viewer
Location:
4 D2.3; 4 65.45 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132220115..132237767, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132492804..132510456, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11566 Neighboring gene STARR-positive B cell enhancer ABC_E9596 Neighboring gene mediator complex subunit 18 Neighboring gene predicted gene, 52758 Neighboring gene STARR-seq mESC enhancer starr_11568 Neighboring gene STARR-seq mESC enhancer starr_11569 Neighboring gene STARR-seq mESC enhancer starr_11570 Neighboring gene nuclear encoded tRNA alanine 8 (anticodon AGC) Neighboring gene STARR-seq mESC enhancer starr_11571 Neighboring gene STARR-seq mESC enhancer starr_11572 Neighboring gene STARR-positive B cell enhancer ABC_E9240 Neighboring gene STARR-positive B cell enhancer ABC_E9013 Neighboring gene ATP synthase inhibitory factor subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC11758

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables PH domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables leucine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables leucine binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on peroxide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within TORC2 signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to leucine IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to leucine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to leucine starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to leucine starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fatty acid beta-oxidation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrial DNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of translation in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of translation in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of lipophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cAMP-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to glucose IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to insulin IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of GATOR2 complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
part_of nucleotide-activated protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144907.1NP_659156.1  sestrin-2

    See identical proteins and their annotated locations for NP_659156.1

    Status: PROVISIONAL

    Source sequence(s)
    BC005672
    Consensus CDS
    CCDS18726.1
    UniProtKB/Swiss-Prot
    P58043
    UniProtKB/TrEMBL
    Q3TCT3
    Related
    ENSMUSP00000030724.9, ENSMUST00000030724.9
    Conserved Domains (1) summary
    pfam04636
    Location:43479
    PA26; PA26 p53-induced protein (sestrin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132220115..132237767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)