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SELENOO selenoprotein O [ Homo sapiens (human) ]

Gene ID: 83642, updated on 23-Nov-2021

Summary

Official Symbol
SELENOOprovided by HGNC
Official Full Name
selenoprotein Oprovided by HGNC
Primary source
HGNC:HGNC:30395
See related
Ensembl:ENSG00000073169 MIM:607917
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SELO
Summary
This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 10.3), liver (RPKM 10.3) and 25 other tissues See more
Orthologs
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Genomic context

See SELENOO in Genome Data Viewer
Location:
22q13.33
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50201011..50217616)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50639440..50656045)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene pannexin 2 Neighboring gene TraB domain containing Neighboring gene uncharacterized LOC105373095 Neighboring gene tubulin gamma complex associated protein 6 Neighboring gene histone deacetylase 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131879

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein adenylylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein adenylyltransferase SelO, mitochondrial
NP_113642.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031454.2NP_113642.1  protein adenylyltransferase SelO, mitochondrial

    See identical proteins and their annotated locations for NP_113642.1

    Status: REVIEWED

    Source sequence(s)
    AY324823
    Consensus CDS
    CCDS43034.1
    UniProtKB/Swiss-Prot
    Q9BVL4
    Related
    ENSP00000370288.2, ENST00000380903.7
    Conserved Domains (1) summary
    cl19499
    Location:43669
    UPF0061; Uncharacterized ACR, YdiU/UPF0061 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    50201011..50217616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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