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ZMIZ2 zinc finger MIZ-type containing 2 [ Homo sapiens (human) ]

Gene ID: 83637, updated on 11-Sep-2019

Summary

Official Symbol
ZMIZ2provided by HGNC
Official Full Name
zinc finger MIZ-type containing 2provided by HGNC
Primary source
HGNC:HGNC:22229
See related
Ensembl:ENSG00000122515 MIM:611196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET27; ZIMP7; hZIMP7; TRAFIP20
Summary
ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]
Expression
Ubiquitous expression in spleen (RPKM 17.3), skin (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See ZMIZ2 in Genome Data Viewer
Location:
7p13
Exon count:
24
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (44748547..44769881)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44788168..44809480)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 4 Neighboring gene oxoglutarate dehydrogenase Neighboring gene OGDH intron CAGE-defined high expression enhancer Neighboring gene uncharacterized LOC105375259 Neighboring gene uncharacterized LOC105375260 Neighboring gene peptidylprolyl isomerase A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1886, DKFZp761I2123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromatin-mediated maintenance of transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear replication fork IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger MIZ domain-containing protein 2
Names
PIAS-like protein Zimp7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300959.1NP_001287888.1  zinc finger MIZ domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001287888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AI494261, AK057378, AL831933, BC110435, HY060154
    Consensus CDS
    CCDS75591.1
    UniProtKB/Swiss-Prot
    Q8NF64
    Related
    ENSP00000409648.1, ENST00000413916.5
    Conserved Domains (3) summary
    cd16791
    Location:539586
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
    cl25887
    Location:149265
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl26247
    Location:215330
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  2. NM_031449.4NP_113637.3  zinc finger MIZ domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_113637.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest isoform (1).
    Source sequence(s)
    AC004859, AK090415, AK128359, AY426594, BI115680, CD367243
    Consensus CDS
    CCDS43576.1
    UniProtKB/Swiss-Prot
    Q8NF64
    Related
    ENSP00000311778.4, ENST00000309315.9
    Conserved Domains (1) summary
    pfam02891
    Location:596644
    zf-MIZ; MIZ/SP-RING zinc finger
  3. NM_174929.2NP_777589.2  zinc finger MIZ domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_777589.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK057378, AK090415, AL831933, AY426594, BC016968, BC021924, CD367243
    Consensus CDS
    CCDS43577.1
    UniProtKB/Swiss-Prot
    Q8NF64
    Related
    ENSP00000265346.7, ENST00000265346.11
    Conserved Domains (1) summary
    pfam02891
    Location:570618
    zf-MIZ; MIZ/SP-RING zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    44748547..44769881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249866.2XP_005249923.1  zinc finger MIZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005249923.1

    Conserved Domains (1) summary
    pfam02891
    Location:605653
    zf-MIZ; MIZ/SP-RING zinc finger
  2. XM_005249869.2XP_005249926.1  zinc finger MIZ domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005249926.1

    UniProtKB/Swiss-Prot
    Q8NF64
    Related
    ENSP00000414723.1, ENST00000441627.5
    Conserved Domains (1) summary
    pfam02891
    Location:596644
    zf-MIZ; MIZ/SP-RING zinc finger
  3. XM_005249870.2XP_005249927.1  zinc finger MIZ domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam02891
    Location:579627
    zf-MIZ; MIZ/SP-RING zinc finger
  4. XM_005249872.2XP_005249929.1  zinc finger MIZ domain-containing protein 2 isoform X5

    See identical proteins and their annotated locations for XP_005249929.1

    UniProtKB/Swiss-Prot
    Q8NF64
    Conserved Domains (1) summary
    pfam02891
    Location:570618
    zf-MIZ; MIZ/SP-RING zinc finger
  5. XM_005249871.2XP_005249928.1  zinc finger MIZ domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    pfam02891
    Location:573621
    zf-MIZ; MIZ/SP-RING zinc finger
  6. XM_005249873.2XP_005249930.1  zinc finger MIZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E7EWM3
    Related
    ENSP00000396601.1, ENST00000433667.5
    Conserved Domains (1) summary
    pfam02891
    Location:564612
    zf-MIZ; MIZ/SP-RING zinc finger
  7. XM_005249867.5XP_005249924.1  zinc finger MIZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005249924.1

    Conserved Domains (1) summary
    pfam02891
    Location:605653
    zf-MIZ; MIZ/SP-RING zinc finger
  8. XM_017012674.1XP_016868163.1  zinc finger MIZ domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    pfam02891
    Location:605653
    zf-MIZ; MIZ/SP-RING zinc finger
  9. XM_005249868.4XP_005249925.1  zinc finger MIZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005249925.1

    Conserved Domains (1) summary
    pfam02891
    Location:605653
    zf-MIZ; MIZ/SP-RING zinc finger
  10. XM_011515566.1XP_011513868.1  zinc finger MIZ domain-containing protein 2 isoform X7

    Conserved Domains (1) summary
    pfam02891
    Location:331379
    zf-MIZ; MIZ/SP-RING zinc finger

RNA

  1. XR_926950.1 RNA Sequence

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