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Zmiz2 zinc finger, MIZ-type containing 2 [ Mus musculus (house mouse) ]

Gene ID: 52915, updated on 8-Dec-2022

Summary

Official Symbol
Zmiz2provided by MGI
Official Full Name
zinc finger, MIZ-type containing 2provided by MGI
Primary source
MGI:MGI:106374
See related
Ensembl:ENSMUSG00000041164 AllianceGenome:MGI:106374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zimp7
Summary
Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in epigenetic maintenance of chromatin in transcription-competent conformation and positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion; nuclear replication fork; and nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ZMIZ2 (zinc finger MIZ-type containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 50.9), spleen adult (RPKM 44.1) and 27 other tissues See more
Orthologs
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Genomic context

See Zmiz2 in Genome Data Viewer
Location:
11 A1; 11 3.95 cM
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6339063..6356162)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6388799..6406162)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46270 Neighboring gene oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene microRNA 7651 Neighboring gene peptidylprolyl isomerase A Neighboring gene H2A.Z histone variant 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • 2410117E06Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger MIZ domain-containing protein 2
Names
PIAS-like protein Zimp7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005867.1NP_001005867.1  zinc finger MIZ domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001005867.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    AL607152, BC063069, CA318375, CB524312, CK617573, W54654
    Consensus CDS
    CCDS24417.1
    UniProtKB/Swiss-Prot
    Q8CIE2
    Related
    ENSMUSP00000099978.4, ENSMUST00000102914.10
    Conserved Domains (2) summary
    PHA03307
    Location:682855
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:565612
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  2. NM_028601.3NP_082877.2  zinc finger MIZ domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_082877.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer isoform (1).
    Source sequence(s)
    AL607152, BC063069, CA318375, CB527314, CK617573, W54654
    Consensus CDS
    CCDS24418.1
    UniProtKB/Swiss-Prot
    Q8BJ00, Q8CIE2
    Related
    ENSMUSP00000105409.2, ENSMUST00000109786.8
    Conserved Domains (2) summary
    PHA03307
    Location:714887
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:597644
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6339063..6356162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246147.2XP_030102007.1  zinc finger MIZ domain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    PHA03307
    Location:680853
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:563610
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  2. XM_030246142.2XP_030102002.1  zinc finger MIZ domain-containing protein 2 isoform X2

    Related
    ENSMUSP00000105408.2, ENSMUST00000109785.2
    Conserved Domains (2) summary
    PHA03307
    Location:688861
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:571618
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  3. XM_006514750.4XP_006514813.1  zinc finger MIZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006514813.1

    UniProtKB/Swiss-Prot
    Q8BJ00, Q8CIE2
    Related
    ENSMUSP00000105410.2, ENSMUST00000109787.8
    Conserved Domains (2) summary
    PHA03307
    Location:714887
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:597644
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  4. XM_030246144.2XP_030102004.1  zinc finger MIZ domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    PHA03307
    Location:682855
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:565612
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  5. XM_011243732.3XP_011242034.1  zinc finger MIZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011242034.1

    UniProtKB/Swiss-Prot
    Q8BJ00, Q8CIE2
    Related
    ENSMUSP00000012612.5, ENSMUST00000012612.11
    Conserved Domains (2) summary
    PHA03307
    Location:714887
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:597644
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  6. XM_030246143.2XP_030102003.1  zinc finger MIZ domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    PHA03307
    Location:688861
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:571618
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  7. XM_030246149.2XP_030102009.1  zinc finger MIZ domain-containing protein 2 isoform X6

    Conserved Domains (2) summary
    PHA03307
    Location:648821
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:531578
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  8. XM_030246148.2XP_030102008.1  zinc finger MIZ domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    PHA03307
    Location:656829
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:539586
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  9. XM_030246145.2XP_030102005.1  zinc finger MIZ domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    PHA03307
    Location:682855
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:565612
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  10. XM_006514748.4XP_006514811.1  zinc finger MIZ domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006514811.1

    UniProtKB/Swiss-Prot
    Q8BJ00, Q8CIE2
    Conserved Domains (2) summary
    PHA03307
    Location:714887
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:597644
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  11. XM_011243734.4XP_011242036.1  zinc finger MIZ domain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    PHA03307
    Location:680853
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:563610
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  12. XM_011243733.4XP_011242035.1  zinc finger MIZ domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8CIE2
    Conserved Domains (2) summary
    PHA03307
    Location:688861
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:571618
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  13. XM_017314664.3XP_017170153.1  zinc finger MIZ domain-containing protein 2 isoform X6

    Conserved Domains (2) summary
    PHA03307
    Location:648821
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:531578
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins
  14. XM_011243735.4XP_011242037.1  zinc finger MIZ domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    PHA03307
    Location:656829
    PHA03307; transcriptional regulator ICP4; Provisional
    cd16791
    Location:539586
    SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins