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Tex11 testis expressed gene 11 [ Mus musculus (house mouse) ]

Gene ID: 83558, updated on 8-Feb-2024

Summary

Official Symbol
Tex11provided by MGI
Official Full Name
testis expressed gene 11provided by MGI
Primary source
MGI:MGI:1933237
See related
Ensembl:ENSMUSG00000009670 AllianceGenome:MGI:1933237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZIP4H; 4930565P14Rik
Summary
Involved in meiotic gene conversion and reciprocal meiotic recombination. Acts upstream of or within several processes, including fertilization; male gonad development; and meiotic chromosome segregation. Located in central element. Colocalizes with synaptonemal complex. Is expressed in oocyte. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 2. Orthologous to human TEX11 (testis expressed 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Tex11 in Genome Data Viewer
Location:
X C3; X 43.72 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (99882254..100103245, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (100838648..101059639, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47637 Neighboring gene predicted gene 14902 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:97972350-97972459 Neighboring gene discs large MAGUK scaffold protein 3 Neighboring gene STARR-seq mESC enhancer starr_47638 Neighboring gene STARR-seq mESC enhancer starr_47639 Neighboring gene sarcoglycan, beta (dystrophin-associated glycoprotein) pseudogene Neighboring gene predicted gene, 24577 Neighboring gene predicted gene, 27510 Neighboring gene 60S ribosomal protein L37-like Neighboring gene high mobility group protein B1-like Neighboring gene predicted gene 3820

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chiasma assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of ectopic germ cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male meiosis chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within male meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic gene conversion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of developmental process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within resolution of meiotic recombination intermediates IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptonemal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in central element IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in central element IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
testis-expressed protein 11
Names
protein ZIP4 homolog
testis-expressed sequence 11 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167997.1NP_001161469.1  testis-expressed protein 11 isoform 2

    See identical proteins and their annotated locations for NP_001161469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK029799, AK082794
    Consensus CDS
    CCDS53150.1
    UniProtKB/Swiss-Prot
    Q14AT2
    Related
    ENSMUSP00000109345.3, ENSMUST00000113716.3
    Conserved Domains (2) summary
    sd00006
    Location:436472
    TPR; TPR repeat [structural motif]
    pfam08631
    Location:176430
    SPO22; Meiosis protein SPO22/ZIP4 like
  2. NM_031384.2NP_113561.2  testis-expressed protein 11 isoform 1

    See identical proteins and their annotated locations for NP_113561.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029799, BC116709
    Consensus CDS
    CCDS30308.1
    UniProtKB/Swiss-Prot
    Q14AT2, Q8BUS0, Q99MW9
    Related
    ENSMUSP00000009814.4, ENSMUST00000009814.10
    Conserved Domains (2) summary
    sd00006
    Location:436472
    TPR; TPR repeat [structural motif]
    pfam08631
    Location:176430
    SPO22; Meiosis protein SPO22/ZIP4 like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    99882254..100103245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)