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Tex11 testis expressed gene 11 [ Mus musculus (house mouse) ]

Gene ID: 83558, updated on 2-Nov-2024

Summary

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Official Symbol
Tex11provided by MGI
Official Full Name
testis expressed gene 11provided by MGI
Primary source
MGI:MGI:1933237
See related
Ensembl:ENSMUSG00000009670 AllianceGenome:MGI:1933237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZIP4H; 4930565P14Rik
Summary
Involved in meiotic gene conversion and reciprocal meiotic recombination. Acts upstream of or within several processes, including male gonad development; meiotic nuclear division; and negative regulation of apoptotic process. Located in central element. Colocalizes with synaptonemal complex. Is expressed in oocyte and testis. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 2. Orthologous to human TEX11 (testis expressed 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Tex11 in Genome Data Viewer
Location:
X C3; X 43.72 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (99882254..100103245, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (100838648..101059639, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47637 Neighboring gene predicted gene 14902 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:97972350-97972459 Neighboring gene discs large MAGUK scaffold protein 3 Neighboring gene STARR-seq mESC enhancer starr_47638 Neighboring gene STARR-seq mESC enhancer starr_47639 Neighboring gene sarcoglycan, beta (dystrophin-associated glycoprotein) pseudogene Neighboring gene predicted gene, 24577 Neighboring gene predicted gene, 27510 Neighboring gene 60S ribosomal protein L37-like Neighboring gene high mobility group protein B1-like Neighboring gene predicted gene 3820

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice. Ghieh F, et al. PLoS One, 2024. PMID 39231187, Free PMC Article
  2. Rescue of male infertility through correcting a genetic mutation causing meiotic arrest in spermatogonial stem cells. Wang YH, et al. Asian J Androl, 2021 Nov-Dec. PMID 33533741, Free PMC Article
  3. ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over. Adelman CA, et al. PLoS Genet, 2008 Mar 28. PMID 18369460, Free PMC Article
  4. Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans. Liu C, et al. EMBO J, 2021 Jul 1. PMID 33978233, Free PMC Article
  5. TEX11 modulates germ cell proliferation by competing with estrogen receptor β for the binding to HPIP. Yu YH, et al. Mol Endocrinol, 2012 Apr. PMID 22383461, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice.
    Title: A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice.
  2. Tex11 regulates genome-wide recombination rates in both sexes in a dosage-dependent manner. An intronless autosomal Tex11 transgene functionally substitutes for the X-linked Tex11 gene, providing genetic evidence for the X-to-autosomal retrotransposition evolution phenomenon.
    Title: TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.
  3. mouse spermatogonial stem cells expressed Tex11, Hpip, and Esr2 but not Esr1, and in cultured cells, TEX11 competed with Esr2 for binding to HPIP.
    Title: TEX11 modulates germ cell proliferation by competing with estrogen receptor β for the binding to HPIP.
  4. Tex11 was first identified from mouse spermatogonia and was specifically expressed in mouse testis.
    Title: An abundance of X-linked genes expressed in spermatogonia.
  5. Zip4h (Tex11), a male germ cell specific X-linked gene was isolated. Zip4h(-/Y) mutant mice were fertile. Analysis of spermatocytes revealed a delay in meiotic double strand break repair and decreased crossover formation.
    Title: ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over.
  6. TEX11 promotes initiation and/or maintenance of synapsis and formation of crossovers, and may provide a physical link between these two meiotic processes.
    Title: Meiotic failure in male mice lacking an X-linked factor.
  7. Tex11 forms discrete foci on meiotic chromosomes. Tex11 is essential for meiosis and fertility in males. Tex11 promotes both chromosomal synapsis and crossover formation in mice and may link these two meiotic processes by interacting with Sycp2 in vivo.
    Title: Meiotic failure in male mice lacking an X-linked factor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chiasma assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of ectopic germ cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within male meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic gene conversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of developmental process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within resolution of meiotic recombination intermediates IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptonemal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in central element IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in central element IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with synaptonemal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
testis-expressed protein 11
Names
protein ZIP4 homolog
testis-expressed sequence 11 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167997.1 → NP_001161469.1  testis-expressed protein 11 isoform 2

    See identical proteins and their annotated locations for NP_001161469.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK029799, AK082794
    Consensus CDS
    CCDS53150.1
    UniProtKB/Swiss-Prot
    Q14AT2
    Related
    ENSMUSP00000109345.3, ENSMUST00000113716.3
    Conserved Domains (2) summary
    sd00006
    Location:436 → 472
    TPR; TPR repeat [structural motif]
    pfam08631
    Location:176 → 430
    SPO22; Meiosis protein SPO22/ZIP4 like

  2. NM_031384.2 → NP_113561.2  testis-expressed protein 11 isoform 1

    See identical proteins and their annotated locations for NP_113561.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029799, BC116709
    Consensus CDS
    CCDS30308.1
    UniProtKB/Swiss-Prot
    Q14AT2, Q8BUS0, Q99MW9
    Related
    ENSMUSP00000009814.4, ENSMUST00000009814.10
    Conserved Domains (2) summary
    sd00006
    Location:436 → 472
    TPR; TPR repeat [structural motif]
    pfam08631
    Location:176 → 430
    SPO22; Meiosis protein SPO22/ZIP4 like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    99882254..100103245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14AT2.1 GenPept UniProtKB/Swiss-Prot:Q14AT2

Gene LinkOut

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