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Plekha2 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 [ Mus musculus (house mouse) ]

Gene ID: 83436, updated on 2-Nov-2024

Summary

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Official Symbol
Plekha2provided by MGI
Official Full Name
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2provided by MGI
Primary source
MGI:MGI:1928144
See related
Ensembl:ENSMUSG00000031557 AllianceGenome:MGI:1928144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAPP2; 6430512N22Rik
Summary
Enables PDZ domain binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of cell-matrix adhesion. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including bone; central nervous system; jaw; thymus primordium; and vomeronasal organ. Orthologous to human PLEKHA2 (pleckstrin homology domain containing A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 8.9), bladder adult (RPKM 7.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Plekha2 in Genome Data Viewer
Location:
8 A2; 8 13.7 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25529160..25594684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25039144..25104679, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene TM2 domain containing 2 Neighboring gene HtrA serine peptidase 4 Neighboring gene STARR-positive B cell enhancer ABC_E6628 Neighboring gene STARR-positive B cell enhancer ABC_E11381 Neighboring gene RIKEN cDNA 5830408C22 gene Neighboring gene STARR-positive B cell enhancer mm9_chr8:26213490-26213791 Neighboring gene STARR-seq mESC enhancer starr_20960 Neighboring gene STARR-positive B cell enhancer ABC_E8231 Neighboring gene STARR-positive B cell enhancer ABC_E11742 Neighboring gene STARR-positive B cell enhancer ABC_E6629 Neighboring gene STARR-seq mESC enhancer starr_20962 Neighboring gene STARR-seq mESC enhancer starr_20963 Neighboring gene predicted gene, 39143 Neighboring gene microRNA 8108 Neighboring gene transforming, acidic coiled-coil containing protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. Wullschleger S, et al. Biochem J, 2011 Mar 1. PMID 21204784, Free PMC Article
  2. Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production. Landego I, et al. Eur J Immunol, 2012 Oct. PMID 22777911
  3. Dual inhibition of phosphoinositide 3-kinases delta and gamma reduces chronic B cell activation and autoantibody production in a mouse model of lupus. Olayinka-Adefemi F, et al. Front Immunol, 2023. PMID 37234154, Free PMC Article
  4. TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor. Marshall AJ, et al. Mol Cell Biol, 2002 Aug. PMID 12101241, Free PMC Article
  5. B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice. Jayachandran N, et al. Eur J Immunol, 2017 Feb. PMID 27859053

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that TAPP1/2 double knock-out mice develop chronic germinal centers with age and show abnormal expression of B-cell activation and develop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys
    Title: B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice.
  2. interacts with phosphatidylinositol (3,4)-bisphosphate thus regulating B-cell activation and autoantibody production
    Title: Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
  
enables laminin binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family A member 2
Names
PH domain-containing adaptor PHAD47
PH domain-containing family A member 2
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2andem PH Domain containing protein 2
tandem PH domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427346.1 → NP_001414275.1  pleckstrin homology domain-containing family A member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156553
    UniProtKB/Swiss-Prot
    Q8BY29, Q9ERS5
    Related
    ENSMUSP00000066546.7, ENSMUST00000064883.14

  2. NM_001427347.1 → NP_001414276.1  pleckstrin homology domain-containing family A member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156553
    UniProtKB/Swiss-Prot
    Q8BY29, Q9ERS5

  3. NM_001427348.1 → NP_001414277.1  pleckstrin homology domain-containing family A member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156553
    UniProtKB/Swiss-Prot
    Q8BY29, Q9ERS5

  4. NM_001427349.1 → NP_001414278.1  pleckstrin homology domain-containing family A member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156553
    UniProtKB/Swiss-Prot
    Q8BY29, Q9ERS5

  5. NM_001427350.1 → NP_001414279.1  pleckstrin homology domain-containing family A member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156553
    UniProtKB/Swiss-Prot
    Q8BY29, Q9ERS5

  6. NM_001427351.1 → NP_001414280.1  pleckstrin homology domain-containing family A member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156553

  7. NM_001427352.1 → NP_001414281.1  pleckstrin homology domain-containing family A member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156553

  8. NM_031257.4 → NP_112547.1  pleckstrin homology domain-containing family A member 2 isoform 1

    See identical proteins and their annotated locations for NP_112547.1

    Status: VALIDATED

    Source sequence(s)
    AC156553
    Consensus CDS
    CCDS22198.1
    UniProtKB/Swiss-Prot
    Q8BY29, Q9ERS5
    Related
    ENSMUSP00000122564.2, ENSMUST00000128715.8
    Conserved Domains (3) summary
    PHA03247
    Location:304 → 410
    PHA03247; large tegument protein UL36; Provisional
    cd13270
    Location:1 → 119
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:192 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    25529160..25594684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154394.1 → XP_036010287.1  pleckstrin homology domain-containing family A member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BY29, Q9ERS5
    Conserved Domains (3) summary
    PHA03247
    Location:304 → 410
    PHA03247; large tegument protein UL36; Provisional
    cd13270
    Location:1 → 119
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:192 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERS5.1 GenPept UniProtKB/Swiss-Prot:Q9ERS5

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