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PLEKHA2 pleckstrin homology domain containing A2 [ Homo sapiens (human) ]

Gene ID: 59339, updated on 18-Aug-2020

Summary

Official Symbol
PLEKHA2provided by HGNC
Official Full Name
pleckstrin homology domain containing A2provided by HGNC
Primary source
HGNC:HGNC:14336
See related
Ensembl:ENSG00000169499 MIM:607773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAPP2
Expression
Broad expression in lymph node (RPKM 32.5), spleen (RPKM 19.2) and 23 other tissues See more
Orthologs

Genomic context

See PLEKHA2 in Genome Data Viewer
Location:
8p11.22
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (38901346..38973912)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38758753..38831431)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 5 pseudogene 1 Neighboring gene transforming acidic coiled-coil containing protein 1 Neighboring gene Sharpr-MPRA regulatory region 13542 Neighboring gene HtrA serine peptidase 4 Neighboring gene TM2 domain containing 2 Neighboring gene ADAM metallopeptidase domain 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibronectin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
laminin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
positive regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology domain-containing family A member 2
Names
PH domain-containing family A member 2
TAPP-2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
tandem PH Domain containing protein-2
tandem PH domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021623.2NP_067636.1  pleckstrin homology domain-containing family A member 2

    See identical proteins and their annotated locations for NP_067636.1

    Status: VALIDATED

    Source sequence(s)
    AA985353, AC108863, AF286164, AK098787, BQ025762, DC332022
    Consensus CDS
    CCDS75732.1
    UniProtKB/Swiss-Prot
    Q9HB19
    UniProtKB/TrEMBL
    A8K727
    Related
    ENSP00000482228.1, ENST00000617275.5
    Conserved Domains (3) summary
    cd13270
    Location:1119
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:192307
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:199297
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    38901346..38973912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544607.3XP_011542909.1  pleckstrin homology domain-containing family A member 2 isoform X1

    See identical proteins and their annotated locations for XP_011542909.1

    UniProtKB/TrEMBL
    A8K727
    Related
    ENSP00000483078.1, ENST00000616834.1
    Conserved Domains (3) summary
    cd13270
    Location:1119
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:192307
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:199297
    PH; PH domain
  2. XM_011544605.3XP_011542907.1  pleckstrin homology domain-containing family A member 2 isoform X1

    See identical proteins and their annotated locations for XP_011542907.1

    UniProtKB/TrEMBL
    A8K727
    Conserved Domains (3) summary
    cd13270
    Location:1119
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:192307
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:199297
    PH; PH domain
  3. XM_024447227.1XP_024302995.1  pleckstrin homology domain-containing family A member 2 isoform X2

    Conserved Domains (2) summary
    cd13270
    Location:1119
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:143258
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
  4. XM_017013720.2XP_016869209.1  pleckstrin homology domain-containing family A member 2 isoform X4

  5. XM_017013719.2XP_016869208.1  pleckstrin homology domain-containing family A member 2 isoform X3

    UniProtKB/TrEMBL
    A0A087WZ32
    Related
    ENSP00000482319.1, ENST00000616927.4
  6. XM_011544606.2XP_011542908.1  pleckstrin homology domain-containing family A member 2 isoform X1

    See identical proteins and their annotated locations for XP_011542908.1

    UniProtKB/TrEMBL
    A8K727
    Conserved Domains (3) summary
    cd13270
    Location:1119
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:192307
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:199297
    PH; PH domain
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