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H2BC14 H2B clustered histone 14 [ Homo sapiens (human) ]

Gene ID: 8342, updated on 10-Dec-2024

Summary

Official Symbol
H2BC14provided by HGNC
Official Full Name
H2B clustered histone 14provided by HGNC
Primary source
HGNC:HGNC:4750
See related
Ensembl:ENSG00000273703 MIM:602802; AllianceGenome:HGNC:4750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2B/e; H2BFE; HIST1H2BM; dJ160A22.3
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2BC14 in Genome Data Viewer
Location:
6p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (27815022..27815489)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27684696..27685163)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27782800..27783267)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:27777495-27778166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:27778167-27778838 Neighboring gene H3 clustered histone 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24314 Neighboring gene H2A clustered histone 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24315 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:27792023-27792664 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:27793307-27793948 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:27793949-27794592 Neighboring gene H4 clustered histone 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:27795877-27796518 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:27798822-27799647 Neighboring gene H4 clustered histone 12

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, histone cluster 1, H2bm (HIST1H2BM), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in nucleosome assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H2B type 1-M
Names
H2B histone family, member E
histone 1, H2bm
histone H2B.e
histone cluster 1 H2B family member m
histone cluster 1, H2bm

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003521.3NP_003512.1  histone H2B type 1-M

    See identical proteins and their annotated locations for NP_003512.1

    Status: REVIEWED

    Source sequence(s)
    AL049822
    Consensus CDS
    CCDS4629.1
    UniProtKB/Swiss-Prot
    Q6NWQ3, Q99879
    UniProtKB/TrEMBL
    A8K9J7, Q0D2M2
    Related
    ENSP00000477907.2, ENST00000621112.2
    Conserved Domains (1) summary
    cl23830
    Location:12125
    H2B; Histone H2B

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    27815022..27815489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    27684696..27685163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)