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H2BC14 H2B clustered histone 14 [ Homo sapiens (human) ]

Gene ID: 8342, updated on 1-Jun-2020

Summary

Official Symbol
H2BC14provided by HGNC
Official Full Name
H2B clustered histone 14provided by HGNC
Primary source
HGNC:HGNC:4750
See related
Ensembl:ENSG00000273703 MIM:602802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2B/e; H2BFE; HIST1H2BM; dJ160A22.3
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Orthologs

Genomic context

See H2BC14 in Genome Data Viewer
Location:
6p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (27815022..27815489)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27782822..27783267)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3 clustered histone 10 Neighboring gene H2A clustered histone 14 Neighboring gene H4 clustered histone 11 Neighboring gene H4 clustered histone 12

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, histone cluster 1, H2bm (HIST1H2BM), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome assembly NAS
Non-traceable Author Statement
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleosome NAS
Non-traceable Author Statement
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H2B type 1-M
Names
H2B histone family, member E
histone 1, H2bm
histone H2B.e
histone cluster 1 H2B family member m
histone cluster 1, H2bm

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003521.3NP_003512.1  histone H2B type 1-M

    See identical proteins and their annotated locations for NP_003512.1

    Status: REVIEWED

    Source sequence(s)
    AL049822
    Consensus CDS
    CCDS4629.1
    UniProtKB/Swiss-Prot
    Q99879
    Related
    ENSP00000477907.1, ENST00000621112.1
    Conserved Domains (1) summary
    cl23830
    Location:12125
    Histone; Core histone H2A/H2B/H3/H4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    27815022..27815489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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