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MKK3 mitogen-activated protein kinase kinase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834042, updated on 18-Sep-2024

Summary

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Official Symbol
MKK3
Official Full Name
mitogen-activated protein kinase kinase 3
Primary source
TAIR:AT5G40440
Locus tag
AT5G40440
See related
Araport:AT5G40440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMKK3; mitogen-activated protein kinase kinase 3; MPO12.150; MPO12_150
Summary
Encodes a mitogen-activated protein kinase kinase. Activates MPK8.
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Genomic context

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Location:
chromosome: 5
Exon count:
10
Sequence:
Chromosome: 5; NC_003076.8 (16181628..16184827)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene myb domain protein 22 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene A-kinase anchor-like protein Neighboring gene ncRNA Neighboring gene cyclin-dependent kinase inhibitor SMR3-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitogen-Activated Protein Kinase Kinase 3 Is Required for Regulation during Dark-Light Transition. Lee H. Mol Cells, 2015 Jul. PMID 26082029, Free PMC Article
  2. Molecular cloning and characterization of three cDNAs encoding putative mitogen-activated protein kinase kinases (MAPKKs) in Arabidopsis thaliana. Ichimura K, et al. DNA Res, 1998 Dec 31. PMID 10048483
  3. The involvement of AtMKK1 and AtMKK3 in plant-deleterious microbial volatile compounds-induced defense responses. Chang CH, et al. Plant Mol Biol, 2023 Jan. PMID 36109466
  4. The Arabidopsis Mitogen-Activated Protein Kinase Kinase Kinase 20 (MKKK20) C-terminal domain interacts with MKK3 and harbors a typical DEF mammalian MAP kinase docking site. Bai F, et al. Plant Signal Behav, 2018. PMID 30081740, Free PMC Article
  5. The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis. Takahashi F, et al. Plant Cell, 2007 Mar. PMID 17369371, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The involvement of AtMKK1 and AtMKK3 in plant-deleterious microbial volatile compounds-induced defense responses.
    Title: The involvement of AtMKK1 and AtMKK3 in plant-deleterious microbial volatile compounds-induced defense responses.
  2. The data suggest a MKK3 * MPK1 * RBK1 phosphorylation cascade that may provide a dynamic module for altering cell expansion.
    Title: An Arabidopsis kinase cascade influences auxin-responsive cell expansion.
  3. This study suggests that MKK3 acts in negative regulation in darkness and in light-induced MAPK activation during dark-light transition.
    Title: Mitogen-Activated Protein Kinase Kinase 3 Is Required for Regulation during Dark-Light Transition.
  4. MKK3-MPK6 is activated by blue light in a MYC2-dependent manner.
    Title: A mitogen-activated protein kinase cascade module, MKK3-MPK6 and MYC2, is involved in blue light-mediated seedling development in Arabidopsis.
  5. Results reveal that the MKK3 pathway plays a role in pathogen defense and further underscore the importance and complexity of MAPK signaling in plant stress responses.
    Title: The Arabidopsis mitogen-activated protein kinase kinase MKK3 is upstream of group C mitogen-activated protein kinases and participates in pathogen signaling.
  6. MAPK KINASE 3 (MKK3)-MAPK 6 (MPK6) unit plays a key role in jasmonic acid-dependent negative regulation of ATMYC2/JIN1 expression.[MKK3]
    Title: The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001344328.1
NM_001344330.1
NM_001344331.1
NM_001344332.1
NM_123408.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to other organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within induced systemic resistance, ethylene mediated signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within induced systemic resistance, jasmonic acid mediated signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to herbivore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase 3
NP_001318713.1
  • mitogen-activated protein kinase kinase 3 (MKK3); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Nuclear transport factor 2, Eukaryote (InterPro:IPR018222), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAP kinase kinase 6 (TAIR:AT5G56580.1); Has 122843 Blast hits to 121436 proteins in 4056 species: Archae - 133; Bacteria - 13736; Metazoa - 45702; Fungi - 12099; Plants - 30883; Viruses - 510; Other Eukaryotes - 19780 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    16181628..16184827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001344329.1 → NP_001332251.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UF93, A0A1P8BGD1

  2. NM_001344328.1 → NP_001318713.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O80396
    UniProtKB/TrEMBL
    A0A178UF93
    Conserved Domains (2) summary
    cd06623
    Location:80 → 344
    PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins
    cd00780
    Location:362 → 461
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  3. NM_001344330.1 → NP_001332252.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UF93, A0A1P8BGD1

  4. NM_123408.3 → NP_198860.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_198860.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O80396
    UniProtKB/TrEMBL
    A0A178UF93
    Conserved Domains (2) summary
    cd06623
    Location:80 → 344
    PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins
    cd00780
    Location:362 → 461
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  5. NM_001344331.1 → NP_001332249.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UF93, A0A1P8BGC3
    Conserved Domains (2) summary
    cd06623
    Location:2 → 262
    PKc_MAPKK_plant_like; Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins
    cd00780
    Location:280 → 379
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  6. NM_001344332.1 → NP_001332250.1  mitogen-activated protein kinase kinase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UF93, A0A1P8BGD1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O80396.1

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