Format

Send to:

Choose Destination

H2AC18 H2A clustered histone 18 [ Homo sapiens (human) ]

Gene ID: 8337, updated on 5-Jul-2020

Summary

Official Symbol
H2AC18provided by HGNC
Official Full Name
H2A clustered histone 18provided by HGNC
Primary source
HGNC:HGNC:4736
See related
Ensembl:ENSG00000203812 MIM:142720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2A; H2A.2; H2A/O; H2A/q; H2AFO; H2AC19; H2a-615; HIST2H2AA; HIST2H2AA3
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]
Orthologs

Genomic context

See H2AC18 in Genome Data Viewer
Location:
1q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (149842218..149842750, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149813785..149814318, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 14 Neighboring gene H3 clustered histone 14 Neighboring gene H2B clustered histone 19, pseudogene Neighboring gene H2B clustered histone 20, pseudogene

Genomic regions, transcripts, and products

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat activated transcription facilitates removal of histones H2A and H2B at the LTR, and the FACT complex, at least consisting of SPT16 and SSRP1, may be responsible for their removal PubMed
tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H2A type 2-A
Names
H2A histone family, member O
H2A-clustered histone 19
histone 2, H2aa3
histone cluster 2 H2A family member a3
histone cluster 2, H2aa3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003516.3NP_003507.1  histone H2A type 2-A

    See identical proteins and their annotated locations for NP_003507.1

    Status: REVIEWED

    Source sequence(s)
    AC239868
    Consensus CDS
    CCDS934.1
    UniProtKB/Swiss-Prot
    Q6FI13
    Related
    ENSP00000358155.2, ENST00000369159.2
    Conserved Domains (1) summary
    PTZ00017
    Location:1130
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    149842218..149842750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center