U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

5-FCL 5-formyltetrahydrofolate cycloligase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831144, updated on 6-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
5-FCL
Gene description
5-formyltetrahydrofolate cycloligase
Primary source
Araport:AT5G13050
Locus tag
AT5G13050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
5-CHO-THF CYCLOLIGASE; 5-formyltetrahydrofolate cycloligase; T19L5.10; T19L5_10
Summary
5-Formyltetrahydrofolate cycloligase (5-CHO-THF cycloligase - AT5G13050.1) regulates/influences under photorespiratory conditions the activity of another gene product, i.e. serine hydroxymethyltransferase (SHMT) due to accumulating amounts of 5-Formyltetrahydrofolate
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 5
Exon count:
8
Sequence:
Chromosome: 5; NC_003076.8 (4136556..4138792, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RNA helicase family protein Neighboring gene Emsy N Terminus (ENT)/ plant Tudor-like domains-containing protein Neighboring gene selenoprotein O Neighboring gene ARMADILLO BTB protein 1 Neighboring gene MSF1-like family protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves. Goyer A, et al. J Biol Chem, 2005 Jul 15. PMID 15888445
  2. Cloning and characterization of mitochondrial 5-formyltetrahydrofolate cycloligase from higher plants. Roje S, et al. J Biol Chem, 2002 Nov 8. PMID 12207015
  3. Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity. Yoo H, et al. Mol Plant, 2020 Jan 6. PMID 31568832, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

NM_001036796.2
NM_121308.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 5-formyltetrahydrofolate cyclo-ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-formyltetrahydrofolate cyclo-ligase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within tetrahydrofolate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
5-formyltetrahydrofolate cycloligase
NP_001031873.1
  • 5-formyltetrahydrofolate cycloligase (5-FCL); CONTAINS InterPro DOMAIN/s: 5-formyltetrahydrofolate cyclo-ligase (InterPro:IPR002698); Has 1110 Blast hits to 1110 proteins in 558 species: Archae - 4; Bacteria - 853; Metazoa - 105; Fungi - 55; Plants - 43; Viruses - 0; Other Eukaryotes - 50 (source: NCBI BLink).
NP_568284.1
  • 5-formyltetrahydrofolate cycloligase (5-FCL); CONTAINS InterPro DOMAIN/s: 5-formyltetrahydrofolate cyclo-ligase (InterPro:IPR002698); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    4136556..4138792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121308.2 → NP_568284.1  5-formyltetrahydrofolate cycloligase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568284.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4K2F3, Q84WD9, Q8L539, Q9FYA5
    UniProtKB/TrEMBL
    A0A178UBC3, A0A654G0R0
    Conserved Domains (1) summary
    PLN02812
    Location:54 → 267
    PLN02812; 5-formyltetrahydrofolate cyclo-ligase

  2. NM_001036796.2 → NP_001031873.1  5-formyltetrahydrofolate cycloligase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031873.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UD81
    Conserved Domains (1) summary
    PLN02812
    Location:54 → 208
    PLN02812; 5-formyltetrahydrofolate cyclo-ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8L539.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools