GA20OX1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GA20OX1
Primary source: TAIR:AT4G25420
Locus tag: AT4G25420
See related: Araport:AT4G25420
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA GIBBERELLIN 20-OXIDASE 1; AT2301; ATGA20OX1; GA REQUIRING 5; GA5; GIBBERELLIN 20-OXIDASE; T30C3.90; T30C3_90
Summary: Encodes gibberellin 20-oxidase that is involved in the later steps of the gibberellin biosynthetic pathway. Regulated by a circadian clock. Weak expression response to far red light.
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Genomic context

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Location:: chromosome: 4

Exon count:: 2

Sequence:: Chromosome: 4; NC_003075.7 (12990851..12992585, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DELLA-GAF1 complex is involved in tissue-specific expression and gibberellin feedback regulation of GA20ox1 in Arabidopsis.
Title: DELLA-GAF1 complex is involved in tissue-specific expression and gibberellin feedback regulation of GA20ox1 in Arabidopsis.
GA20ox1 expression affects gibberellin responses.
Title: Natural Variation of Molecular and Morphological Gibberellin Responses.
We propose that cytokinin activity increased due to a KNOX-mediated transcriptional feedback loop resulting from the higher GNP1 transcript levels, in turn leading to increased expression of the GA catabolism genes GA2oxs and reduced GA1 and GA3 accumulation.
Title: The QTL GNP1 Encodes GA20ox1, Which Increases Grain Number and Yield by Increasing Cytokinin Activity in Rice Panicle Meristems.
GA20-OX1 plants accumulated more vegetative biomass than control plants in greenhouse experiments.
Title: Overexpression of GA20-OXIDASE1 impacts plant height, biomass allocation and saccharification efficiency in maize.
Mutations in the early steps of the GA biosynthesis pathway led to a reduction in shoot as well as root size. Mutations at the GA5 locus yielded phenotypes characterized by decreased root length in comparison with related wild-type ones.
Title: Phenotype of Arabidopsis thaliana semi-dwarfs with deep roots and high growth rates under water-limiting conditions is independent of the GA5 loss-of-function alleles.
A loss-of-function mutation due to a single nucleotide deletion in gibberellin20-oxidase1 (GA5) was identified as the cause of dwarfism in an alpine accession.
Title: A Single Nucleotide Deletion in Gibberellin20-oxidase1 Causes Alpine Dwarfism in Arabidopsis.
antagonistic pleiotropy might underlie the occurrence of GA5 loss-of-function mutations in nature.
Title: Arabidopsis semidwarfs evolved from independent mutations in GA20ox1, ortholog to green revolution dwarf alleles in rice and barley.
Loss of GA20ox1, -2, and -3 blocks germination, causes severe dwarfism, delays flowering, and causes male and female sterility.
Title: Analysis of the developmental roles of the Arabidopsis gibberellin 20-oxidases demonstrates that GA20ox1, -2, and -3 are the dominant paralogs.
Data show the model of the gene expression feedback regulation of GID1, GA20ox, and GA3ox, and DELLA with gibberellin.
Title: Mathematical modeling elucidates the role of transcriptional feedback in gibberellin signaling.
Studies indicate that GA5 gene encodes a GA 20-oxidase that catalyzes the formation of the GA20 and GA9.
Title: Genetic analyses of interactions among gibberellin, abscisic acid, and brassinosteroids in the control of flowering time in Arabidopsis thaliana.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_001341731.1

Supported by ESTs:

NM_118674.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables gibberellin 20-oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables gibberellin 20-oxidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within flower development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gibberellic acid mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within gibberellin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in gibberellin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gibberellin biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within leaf development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to gibberellin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within short-day photoperiodism, flowering	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within unidimensional cell growth	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

NP_194272.1

GA20OX1; CONTAINS InterPro DOMAIN/s: Isopenicillin N synthase (InterPro:IPR002283), Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: gibberellin 20 oxidase 2 (TAIR:AT5G51810.1); Has 8544 Blast hits to 8501 proteins in 990 species: Archae - 0; Bacteria - 1084; Metazoa - 124; Fungi - 981; Plants - 4942; Viruses - 0; Other Eukaryotes - 1413 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

12990851..12992585 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118674.5 → NP_194272.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194272.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38844, Q39110, Q9FYN4, Q9FYN5, Q9STJ5

UniProtKB/TrEMBL

A0A178UV19, A0A654FSN4, Q56Y27, U3MZ83, U3MZ99, U3MZJ7, U3MZK0, U3N144, U3N151, U3N1S3, U3N1U1, U3N6F2, U3N6H3

Conserved Domains (1) summary

PLN02276
Location:22 → 373

PLN02276; gibberellin 20-oxidase
NM_001341731.1 → NP_001328762.1 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B5N0, U3N1S9