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CAPG capping actin protein, gelsolin like [ Homo sapiens (human) ]

Gene ID: 822, updated on 11-Sep-2019

Summary

Official Symbol
CAPGprovided by HGNC
Official Full Name
capping actin protein, gelsolin likeprovided by HGNC
Primary source
HGNC:HGNC:1474
See related
Ensembl:ENSG00000042493 MIM:153615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCP; AFCP; HEL-S-66
Summary
This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
Expression
Broad expression in lung (RPKM 44.7), esophagus (RPKM 37.5) and 22 other tissues See more
Orthologs

Genomic context

See CAPG in Genome Data Viewer
Location:
2p11.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (85394748..85418467, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85621871..85641197, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene retinol saturase Neighboring gene ELMO domain containing 3 Neighboring gene RNA, 7SL, cytoplasmic 113, pseudogene Neighboring gene uncharacterized LOC105374841 Neighboring gene SH2 domain containing 6 Neighboring gene RNA, U7 small nuclear 64 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with CAPG in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of capping protein gelsolin-like (CAPG) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
NOT extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT positive regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
F-actin capping protein complex TAS
Traceable Author Statement
more info
PubMed 
Flemming body IDA
Inferred from Direct Assay
more info
PubMed 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
macrophage-capping protein
Names
actin-regulatory protein CAP-G
capping protein (actin filament), gelsolin-like
epididymis secretory protein Li 66
gelsolin-like capping protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256139.1NP_001243068.1  macrophage-capping protein isoform 1

    See identical proteins and their annotated locations for NP_001243068.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AK130130, AK313898, AU099216, BU626913
    Consensus CDS
    CCDS1974.1
    UniProtKB/Swiss-Prot
    P40121
    UniProtKB/TrEMBL
    B2R9S4, V9HW69
    Related
    ENSP00000386965.1, ENST00000409724.5
    Conserved Domains (3) summary
    cd11289
    Location:137225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
  2. NM_001256140.1NP_001243069.1  macrophage-capping protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK130130, AK225374, BU626913
    Consensus CDS
    CCDS58715.1
    UniProtKB/Swiss-Prot
    P40121
    Related
    ENSP00000387063.1, ENST00000409921.5
    Conserved Domains (3) summary
    cd11289
    Location:137208
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:236331
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
  3. NM_001320732.1NP_001307661.1  macrophage-capping protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    BG762391, FJ224312
    Consensus CDS
    CCDS1974.1
    UniProtKB/Swiss-Prot
    P40121
    UniProtKB/TrEMBL
    V9HW69
    Conserved Domains (3) summary
    cd11289
    Location:137225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
  4. NM_001320733.1NP_001307662.1  macrophage-capping protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    BG762114, FJ224312
    Consensus CDS
    CCDS1974.1
    UniProtKB/Swiss-Prot
    P40121
    UniProtKB/TrEMBL
    V9HW69
    Conserved Domains (3) summary
    cd11289
    Location:137225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
  5. NM_001320734.1NP_001307663.1  macrophage-capping protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK130130, BU172582, FJ224312
    UniProtKB/TrEMBL
    V9HW69
    Conserved Domains (3) summary
    cd11289
    Location:137223
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:221315
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
  6. NM_001747.4NP_001738.2  macrophage-capping protein isoform 1

    See identical proteins and their annotated locations for NP_001738.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AK130130, BU626913
    Consensus CDS
    CCDS1974.1
    UniProtKB/Swiss-Prot
    P40121
    UniProtKB/TrEMBL
    V9HW69
    Related
    ENSP00000263867.4, ENST00000263867.9
    Conserved Domains (3) summary
    cd11289
    Location:137225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    85394748..85418467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533122.1XP_011531424.1  macrophage-capping protein isoform X1

    See identical proteins and their annotated locations for XP_011531424.1

    UniProtKB/Swiss-Prot
    P40121
    UniProtKB/TrEMBL
    V9HW69
    Conserved Domains (3) summary
    cd11289
    Location:137225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
  2. XM_011533123.1XP_011531425.1  macrophage-capping protein isoform X1

    See identical proteins and their annotated locations for XP_011531425.1

    UniProtKB/Swiss-Prot
    P40121
    UniProtKB/TrEMBL
    V9HW69
    Conserved Domains (3) summary
    cd11289
    Location:137225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:251346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
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