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CLTCL1 clathrin heavy chain like 1 [ Homo sapiens (human) ]

Gene ID: 8218, updated on 4-Feb-2026
Official Symbol
CLTCL1provided by HGNC
Official Full Name
clathrin heavy chain like 1provided by HGNC
Primary source
HGNC:HGNC:2093
See related
Ensembl:ENSG00000070371 MIM:601273; AllianceGenome:HGNC:2093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLTD; CHC22; CLH22; CLTCL
Summary
This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Expression
Biased expression in testis (RPKM 21.0), bone marrow (RPKM 6.6) and 8 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CLTCL1 in Genome Data Viewer
Location:
22q11.21
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (19179473..19291719, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (19555423..19668426, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19166986..19279242, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:19159167-19160103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19162549-19163296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19165547-19166294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13457 Neighboring gene long intergenic non-protein coding RNA 1311 Neighboring gene solute carrier family 25 member 1 Neighboring gene uncharacterized LOC112268289 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19205227-19205964 Neighboring gene NANOG hESC enhancer GRCh37_chr22:19210904-19211455 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:19220751-19221950 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene ribosomal protein L34 pseudogene 35 Neighboring gene keratin 18 pseudogene 62 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19262319-19262820 Neighboring gene dishevelled segment polarity protein 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19262821-19263320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19278431-19278944 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:19279055-19279239 Neighboring gene uncharacterized LOC105372859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19284079-19284580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19284581-19285080 Neighboring gene histone cell cycle regulator Neighboring gene RNA, 7SL, cytoplasmic 168, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development. Nahorski MS, et al. Brain, 2015 Aug. PMID 26068709, Free PMC Article
  2. Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome. Sirotkin H, et al. Hum Mol Genet, 1996 May. PMID 8733128
  3. Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL). Long KR, et al. Genomics, 1996 Aug 1. PMID 8844170
  4. Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development. Nahorski MS, et al. Sci Rep, 2018 Feb 5. PMID 29402896, Free PMC Article
  5. Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism. Fumagalli M, et al. Elife, 2019 Jun 4. PMID 31159924, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
    Title: Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
  2. These analyses suggest that ancestral human dietary change influenced selection of allotypes that affect CHC22's role in metabolism and have potential to differentially influence the human insulin response.
    Title: Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism.
  3. Provide biochemical evidence for separate regulation and distinct functional niches for CHC17 and CHC22 in HeLa cells. Furthermore, the greater stability of the CHC22 coat relative to the CHC17 coat may be relevant to its excessive accumulation with GLUT4 during insulin resistance.
    Title: CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.
  4. Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development. Study suggests This suggests that a reduction in CHC22 expression in sensory neural precursors may license a step in neuron precursor neurodevelopment; and that this step is mediated through control of a novel neuropeptide processing pathway.
    Title: Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development.
  5. CLTCL1 is significantly upregulated in the developing human brain
    Title: A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development.
  6. Depletion of clathrin heavy chain (CHC)17, but not the CHC22 clathrin isoform, by ribonucleic acid interference (RNAi) induces centrosome amplification and multipolar spindles.
    Title: Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.
  7. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
    Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. CHC22 was required for retrograde trafficking of certain cargo molecules from endosomes to the trans-Golgi network.
    Title: The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.
  10. role for CHC22 in formation of insulin-responsive GLUT4 compartments in muscle & adipocytes; CHC22 associated with expanded GLUT4 compartments in muscle in type 2 diabetes
    Title: A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies CLTCL1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ36032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin light chain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of D-glucose import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of clathrin coat of trans-Golgi network vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of clathrin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated endocytic vesicle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
NOT located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
NOT located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sorting endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
clathrin heavy chain 2
Names
CLH-22
Clathrin, heavy polypeptide D
clathrin heavy chain on chromosome 22
clathrin, heavy polypeptide-like 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033805.1 RefSeqGene

    Range
    4998..117244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001835.4 → NP_001826.3  clathrin heavy chain 2 isoform 2

    See identical proteins and their annotated locations for NP_001826.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AC000085, AK302506, BP281338, U41763
    Consensus CDS
    CCDS54497.2
    UniProtKB/Swiss-Prot
    P53675
    Related
    ENSP00000485020.1, ENST00000621271.4
    Conserved Domains (5) summary
    smart00299
    Location:979 → 1119
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:983 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364 → 421
    Clathrin_H_link; Clathrin-H-link

  2. NM_007098.4 → NP_009029.3  clathrin heavy chain 2 isoform 1

    See identical proteins and their annotated locations for NP_009029.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC000085, AK302506, BP281338, U41763, X95486
    Consensus CDS
    CCDS46662.2
    UniProtKB/Swiss-Prot
    B7Z7U5, P53675, Q14017, Q15808, Q15809
    Related
    ENSP00000441158.1, ENST00000427926.6
    Conserved Domains (5) summary
    smart00299
    Location:979 → 1119
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:1427 → 1564
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 353
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:364 → 421
    Clathrin_H_link; Clathrin-H-link

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    19179473..19291719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441517.1 → XP_047297473.1  clathrin heavy chain 2 isoform X11

    Related
    ENSP00000635556.1, ENST00000965497.1

  2. XM_047441515.1 → XP_047297471.1  clathrin heavy chain 2 isoform X9

    Related
    ENSP00000635560.1, ENST00000965501.1

  3. XM_017028954.3 → XP_016884443.1  clathrin heavy chain 2 isoform X2

    Related
    ENSP00000567191.1, ENST00000897132.1

  4. XM_047441518.1 → XP_047297474.1  clathrin heavy chain 2 isoform X12

  5. XM_047441516.1 → XP_047297472.1  clathrin heavy chain 2 isoform X10

    Related
    ENSP00000635572.1, ENST00000965513.1

  6. XM_047441513.1 → XP_047297469.1  clathrin heavy chain 2 isoform X5

  7. XM_047441511.1 → XP_047297467.1  clathrin heavy chain 2 isoform X3

    Related
    ENSP00000602528.1, ENST00000932469.1

  8. XM_017028956.3 → XP_016884445.1  clathrin heavy chain 2 isoform X7

    Related
    ENSP00000635554.1, ENST00000965495.1

  9. XM_047441512.1 → XP_047297468.1  clathrin heavy chain 2 isoform X4

    Related
    ENSP00000567192.1, ENST00000897133.1

  10. XM_017028953.3 → XP_016884442.1  clathrin heavy chain 2 isoform X1

    Related
    ENSP00000567193.1, ENST00000897134.1

  11. XM_017028955.3 → XP_016884444.1  clathrin heavy chain 2 isoform X6

  12. XM_047441514.1 → XP_047297470.1  clathrin heavy chain 2 isoform X8

  13. XM_011530401.2 → XP_011528703.1  clathrin heavy chain 2 isoform X18

    Conserved Domains (2) summary
    smart00299
    Location:376 → 516
    CLH; Clathrin heavy chain repeat homology
    pfam00637
    Location:824 → 961
    Clathrin; Region in Clathrin and VPS

  14. XM_047441520.1 → XP_047297476.1  clathrin heavy chain 2 isoform X14

  15. XM_047441519.1 → XP_047297475.1  clathrin heavy chain 2 isoform X13

  16. XM_047441521.1 → XP_047297477.1  clathrin heavy chain 2 isoform X15

    UniProtKB/TrEMBL
    A0A087WX41
    Related
    ENSP00000480709.1, ENST00000617103.4

  17. XM_047441522.1 → XP_047297478.1  clathrin heavy chain 2 isoform X16

  18. XM_017028957.3 → XP_016884446.1  clathrin heavy chain 2 isoform X17

  19. XM_047441523.1 → XP_047297479.1  clathrin heavy chain 2 isoform X17

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    19555423..19668426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325964.1 → XP_054181939.1  clathrin heavy chain 2 isoform X11

  2. XM_054325962.1 → XP_054181937.1  clathrin heavy chain 2 isoform X9

  3. XM_054325955.1 → XP_054181930.1  clathrin heavy chain 2 isoform X2

  4. XM_054325965.1 → XP_054181940.1  clathrin heavy chain 2 isoform X12

  5. XM_054325963.1 → XP_054181938.1  clathrin heavy chain 2 isoform X10

  6. XM_054325958.1 → XP_054181933.1  clathrin heavy chain 2 isoform X5

  7. XM_054325956.1 → XP_054181931.1  clathrin heavy chain 2 isoform X3

  8. XM_054325960.1 → XP_054181935.1  clathrin heavy chain 2 isoform X7

  9. XM_054325957.1 → XP_054181932.1  clathrin heavy chain 2 isoform X4

  10. XM_054325954.1 → XP_054181929.1  clathrin heavy chain 2 isoform X1

  11. XM_054325959.1 → XP_054181934.1  clathrin heavy chain 2 isoform X6

  12. XM_054325961.1 → XP_054181936.1  clathrin heavy chain 2 isoform X8

  13. XM_054325972.1 → XP_054181947.1  clathrin heavy chain 2 isoform X18

  14. XM_054325967.1 → XP_054181942.1  clathrin heavy chain 2 isoform X14

  15. XM_054325966.1 → XP_054181941.1  clathrin heavy chain 2 isoform X13

  16. XM_054325968.1 → XP_054181943.1  clathrin heavy chain 2 isoform X15

    UniProtKB/TrEMBL
    A0A087WX41

  17. XM_054325969.1 → XP_054181944.1  clathrin heavy chain 2 isoform X16

  18. XM_054325971.1 → XP_054181946.1  clathrin heavy chain 2 isoform X17

  19. XM_054325970.1 → XP_054181945.1  clathrin heavy chain 2 isoform X17

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53675.2 GenPept UniProtKB/Swiss-Prot:P53675

Gene LinkOut

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