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LZTR1 leucine zipper like transcription regulator 1 [ Homo sapiens (human) ]

Gene ID: 8216, updated on 9-Feb-2020

Summary

Official Symbol
LZTR1provided by HGNC
Official Full Name
leucine zipper like transcription regulator 1provided by HGNC
Primary source
HGNC:HGNC:6742
See related
Ensembl:ENSG00000099949 MIM:600574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NS2; NS10; BTBD29; LZTR-1; SWNTS2
Summary
This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 12.6), ovary (RPKM 12.5) and 25 other tissues See more
Orthologs

Genomic context

See LZTR1 in Genome Data Viewer
Location:
22q11.21; 22q11.1-q11.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (20982297..20999032)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21336558..21353326)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1637 Neighboring gene apoptosis inducing factor mitochondria associated 3 Neighboring gene Sharpr-MPRA regulatory region 818 Neighboring gene THAP7 antisense RNA 1 Neighboring gene THAP domain containing 7 Neighboring gene tubulin alpha 3f pseudogene Neighboring gene purinergic receptor P2X 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: AIFM3

Homology

Clone Names

  • MGC21205

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
Ras GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leucine-zipper-like transcriptional regulator 1
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034193.1 RefSeqGene

    Range
    5029..21764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006767.4NP_006758.2  leucine-zipper-like transcriptional regulator 1

    See identical proteins and their annotated locations for NP_006758.2

    Status: REVIEWED

    Source sequence(s)
    BC026214, CT841521, DA194822
    Consensus CDS
    CCDS33606.1
    UniProtKB/Swiss-Prot
    Q8N653
    Related
    ENSP00000496779.1, ENST00000646124.2
    Conserved Domains (5) summary
    cd14821
    Location:574634
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    sd00038
    Location:68114
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:665753
    BTB; BTB/POZ domain
    cl02518
    Location:433573
    BTB; BTB/POZ domain
    cl26061
    Location:160407
    PLN02193; nitrile-specifier protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    20982297..20999032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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