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CABLES2 Cdk5 and Abl enzyme substrate 2 [ Homo sapiens (human) ]

Gene ID: 81928, updated on 24-Nov-2020

Summary

Official Symbol
CABLES2provided by HGNC
Official Full Name
Cdk5 and Abl enzyme substrate 2provided by HGNC
Primary source
HGNC:HGNC:16143
See related
Ensembl:ENSG00000149679 MIM:618772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ik3-2; C20orf150; dJ908M14.2
Expression
Broad expression in testis (RPKM 25.7), heart (RPKM 3.5) and 19 other tissues See more
Orthologs

Genomic context

See CABLES2 in Genome Data Viewer
Location:
20q13.33
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (62388630..62407283, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60963686..60982339, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372708 Neighboring gene ribosomal protein S21 Neighboring gene uncharacterized LOC105372709 Neighboring gene RBBP8 N-terminal like Neighboring gene uncharacterized LOC105372710

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CDK5 and ABL1 enzyme substrate 2
Names
interactor with CDK3 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031215.2NP_112492.2  CDK5 and ABL1 enzyme substrate 2

    See identical proteins and their annotated locations for NP_112492.2

    Status: VALIDATED

    Source sequence(s)
    AI066606, AL121832, BC003122, CB960872
    Consensus CDS
    CCDS33503.1
    UniProtKB/Swiss-Prot
    Q9BTV7
    Related
    ENSP00000279101.5, ENST00000279101.9
    Conserved Domains (2) summary
    cd00043
    Location:362418
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    cl00266
    Location:410454
    HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    62388630..62407283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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