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Cables2 CDK5 and Abl enzyme substrate 2 [ Mus musculus (house mouse) ]

Gene ID: 252966, updated on 26-Sep-2022

Summary

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Official Symbol
Cables2provided by MGI
Official Full Name
CDK5 and Abl enzyme substrate 2provided by MGI
Primary source
MGI:MGI:2182335
See related
Ensembl:ENSMUSG00000038990 AllianceGenome:MGI:2182335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ik3-2
Summary
Predicted to be involved in regulation of cell cycle. Predicted to act upstream of or within cell division. Orthologous to human CABLES2 (Cdk5 and Abl enzyme substrate 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 17.8), CNS E18 (RPKM 17.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cables2 in Genome Data Viewer
Location:
2; 2 H4
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179900332..179915283, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180258539..180273490, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microRNA 7005 Neighboring gene laminin, alpha 5 Neighboring gene microRNA 3091 Neighboring gene ribosomal protein S21 Neighboring gene RBBP8 N-terminal like Neighboring gene predicted gene, 29943

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo. Hasan ASH, et al. Exp Anim, 2021 Feb 6. PMID 32779618, Free PMC Article
  2. Computational analysis and prediction of the binding motif and protein interacting partners of the Abl SH3 domain. Hou T, et al. PLoS Comput Biol, 2006 Jan. PMID 16446784, Free PMC Article
  3. Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Dinh TTH, et al. Elife, 2021 May 5. PMID 33949947, Free PMC Article
  4. ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. Sato H, et al. Biochim Biophys Acta, 2002 Mar 19. PMID 11955625
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.
    Title: Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.
  2. Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo.
    Title: Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
CDK5 and ABL1 enzyme substrate 2
Names
interactor with CDK3 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411354.1 → NP_001398283.1  CDK5 and ABL1 enzyme substrate 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663027

  2. NM_001411357.1 → NP_001398286.1  CDK5 and ABL1 enzyme substrate 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663027

  3. NM_001411361.1 → NP_001398290.1  CDK5 and ABL1 enzyme substrate 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL663027

  4. NM_001411365.1 → NP_001398294.1  CDK5 and ABL1 enzyme substrate 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL663027

  5. NM_145851.2 → NP_665850.2  CDK5 and ABL1 enzyme substrate 2 isoform 1

    See identical proteins and their annotated locations for NP_665850.2

    Status: VALIDATED

    Source sequence(s)
    AL663027
    Consensus CDS
    CCDS38377.1
    UniProtKB/Swiss-Prot
    A2ABW9, Q8K3M5
    Related
    ENSMUSP00000104519.2, ENSMUST00000108891.2
    Conserved Domains (1) summary
    cd00043
    Location:360 → 416
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RNA

  1. NR_177224.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  2. NR_177225.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  3. NR_177226.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  4. NR_177227.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  5. NR_177228.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  6. NR_177229.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  7. NR_177230.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  8. NR_177231.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  9. NR_177232.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  10. NR_177233.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  11. NR_177234.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

  12. NR_177235.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL663027

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    179900332..179915283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500629.1 → XP_006500692.1  CDK5 and ABL1 enzyme substrate 2 isoform X1

    Conserved Domains (1) summary
    cd00043
    Location:336 → 392
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RNA

  1. XR_001782621.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3M5.2 GenPept UniProtKB/Swiss-Prot:Q8K3M5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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