PVA12 plant VAP homolog 12 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: PVA12
Gene description: plant VAP homolog 12
Primary source: Araport:AT2G45140
Locus tag: AT2G45140
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: plant VAP homolog 12; T14P1.5
Summary: Encodes a Plant VAMP-Associated protein that localizes to the ER and binds to the sitosterol-binding protein ORP3a. The WFDE motif in ORP3a appears to be important for this direct interaction. Mutation of this motif causes ORP3a to relocalize to the Golgi and cytosol. The interaction between PVA12 and ORP3a does not appear to be sterol-dependent.
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Genomic context

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Location:: chromosome: 2

Exon count:: 8

Sequence:: Chromosome: 2; NC_003071.7 (18610806..18613302)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VAP27-proteins bridge the endoplasmic reticulum with endocytic membranes and maintain endocytic traffic, likely through their interaction with clathrin.[VAP27-3]
Title: Plant Endocytosis Requires the ER Membrane-Anchored Proteins VAP27-1 and VAP27-3.
PVA12 is the receptor of ORP3a on the endoplasmic reticulum. Disruption of the ORP3a-PVA12 interaction leads to a redistribution of ORP3a to the Golgi apparatus.
Title: The targeting of the oxysterol-binding protein ORP3a to the endoplasmic reticulum relies on the plant VAP33 homolog PVA12.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001337116.1

Supported by ESTs:

NM_130077.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein targeting	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: plant VAP homolog 12

NP_182039.1

plant VAP homolog 12 (PVA12); FUNCTIONS IN: structural molecule activity; LOCATED IN: cytosol, endoplasmic reticulum, nucleus, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: PapD-like (InterPro:IPR008962), Major sperm protein (InterPro:IPR000535), Vesicle-associated membrane protein (InterPro:IPR016763); BEST Arabidopsis thaliana protein match is: vesicle associated protein (TAIR:AT3G60600.1); Has 1106 Blast hits to 1079 proteins in 208 species: Archae - 0; Bacteria - 0; Metazoa - 441; Fungi - 140; Plants - 434; Viruses - 0; Other Eukaryotes - 91 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18610806..18613302

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130077.3 → NP_182039.1 plant VAP homolog 12 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_182039.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SHC8

UniProtKB/TrEMBL

A0A178W0Q8, A0A5S9X7M3

Conserved Domains (1) summary

pfam00635
Location:5 → 112

Motile_Sperm; MSP (Major sperm protein) domain
NM_001337116.1 → NP_001324913.1 plant VAP homolog 12 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B1Q1