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MIA MIA SH3 domain containing [ Homo sapiens (human) ]

Gene ID: 8190, updated on 21-Dec-2019

Summary

Official Symbol
MIAprovided by HGNC
Official Full Name
MIA SH3 domain containingprovided by HGNC
Primary source
HGNC:HGNC:7076
See related
Ensembl:ENSG00000261857 MIM:601340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD-RAP
Expression
Biased expression in stomach (RPKM 20.5), salivary gland (RPKM 4.7) and 2 other tissues See more
Orthologs

Genomic context

See MIA in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (40775160..40777490)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41281082..41283398)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene inositol-trisphosphate 3-kinase C Neighboring gene chromosome 19 open reading frame 54 Neighboring gene small nuclear ribonucleoprotein polypeptide A Neighboring gene MIA-RAB4B readthrough (NMD candidate) Neighboring gene RAB4B-EGLN2 readthrough (NMD candidate) Neighboring gene RAB4B, member RAS oncogene family Neighboring gene egl-9 family hypoxia inducible factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies three new risk loci for Kawasaki disease.
NHGRI GWA Catalog
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The expression of melanoma inhibitory activity gene (MIA) is upregulated in both Jurkat-Tat101 and Jurkat-Tat72 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough MIA-RAB4B

Readthrough gene: MIA-RAB4B, Included gene: RAB4B

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
melanoma-derived growth regulatory protein
Names
melanoma inhibitory activity

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202553.2NP_001189482.1  melanoma-derived growth regulatory protein precursor

    See identical proteins and their annotated locations for NP_001189482.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC020945, BM715936, BM856478, BQ681978
    Consensus CDS
    CCDS12566.1
    UniProtKB/Swiss-Prot
    Q16674
    UniProtKB/TrEMBL
    A0A024R0P1
    Related
    ENSP00000470129.1, ENST00000594436.5
    Conserved Domains (1) summary
    cd11890
    Location:33130
    MIA; Melanoma Inhibitory Activity protein
  2. NM_006533.4NP_006524.1  melanoma-derived growth regulatory protein precursor

    See identical proteins and their annotated locations for NP_006524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC005910, BM856478
    Consensus CDS
    CCDS12566.1
    UniProtKB/Swiss-Prot
    Q16674
    UniProtKB/TrEMBL
    A0A024R0P1
    Related
    ENSP00000263369.2, ENST00000263369.4
    Conserved Domains (1) summary
    cd11890
    Location:33130
    MIA; Melanoma Inhibitory Activity protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    40775160..40777490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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