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SFXN3 sideroflexin 3 [ Homo sapiens (human) ]

Gene ID: 81855, updated on 2-Jul-2021

Summary

Official Symbol
SFXN3provided by HGNC
Official Full Name
sideroflexin 3provided by HGNC
Primary source
HGNC:HGNC:16087
See related
Ensembl:ENSG00000107819 MIM:615571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFX3; SLC56A3; BA108L7.2
Expression
Ubiquitous expression in small intestine (RPKM 25.7), duodenum (RPKM 19.3) and 23 other tissues See more
Orthologs
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Genomic context

See SFXN3 in Genome Data Viewer
Location:
10q24.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (101031234..101041243)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102790991..102800998)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper tumor suppressor 2 Neighboring gene PDZ domain containing 7 Neighboring gene uncharacterized LOC107984262 Neighboring gene Sharpr-MPRA regulatory region 11881 Neighboring gene Kazal type serine peptidase inhibitor domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of sideroflexin 3 (SFXN3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388027.1NP_001374956.1  sideroflexin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL133215
    Conserved Domains (1) summary
    pfam03820
    Location:13329
    Mtc; Tricarboxylate carrier
  2. NM_001388028.1NP_001374957.1  sideroflexin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL133215
    Conserved Domains (1) summary
    pfam03820
    Location:13329
    Mtc; Tricarboxylate carrier
  3. NM_001388029.1NP_001374958.1  sideroflexin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL133215
    Conserved Domains (1) summary
    pfam03820
    Location:13325
    Mtc; Tricarboxylate carrier
  4. NM_001388030.1NP_001374959.1  sideroflexin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL133215
    Conserved Domains (1) summary
    pfam03820
    Location:13325
    Mtc; Tricarboxylate carrier
  5. NM_001388031.1NP_001374960.1  sideroflexin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL133215
    Conserved Domains (1) summary
    pfam03820
    Location:13325
    Mtc; Tricarboxylate carrier
  6. NM_001388032.1NP_001374961.1  sideroflexin-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL133215
    Conserved Domains (1) summary
    pfam03820
    Location:13308
    Mtc; Tricarboxylate carrier
  7. NM_001388033.1NP_001374962.1  sideroflexin-3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL133215
    Conserved Domains (1) summary
    pfam03820
    Location:13285
    Mtc; Tricarboxylate carrier
  8. NM_001388034.1NP_001374963.1  sideroflexin-3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL133215
    Conserved Domains (1) summary
    pfam03820
    Location:1230
    Mtc; Tricarboxylate carrier
  9. NM_001388035.1NP_001374964.1  sideroflexin-3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL133215
    Conserved Domains (1) summary
    pfam03820
    Location:1230
    Mtc; Tricarboxylate carrier
  10. NM_030971.6NP_112233.3  sideroflexin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL133215
    Consensus CDS
    CCDS7508.2
    Related
    ENSP00000224807.5, ENST00000224807.9

RNA

  1. NR_157572.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133215
  2. NR_170874.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133215
  3. NR_170875.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133215
  4. NR_170876.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133215
  5. NR_170877.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133215
  6. NR_170878.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133215
  7. NR_170879.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133215
  8. NR_170880.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL133215

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    101031234..101041243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_945825.3 RNA Sequence

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