U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Jdp2 Jun dimerization protein 2 [ Mus musculus (house mouse) ]

Gene ID: 81703, updated on 8-Feb-2024

Summary

Official Symbol
Jdp2provided by MGI
Official Full Name
Jun dimerization protein 2provided by MGI
Primary source
MGI:MGI:1932093
See related
Ensembl:ENSMUSG00000034271 AllianceGenome:MGI:1932093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIF; Jundm2; Jundp2
Summary
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Acts upstream of or within with a negative effect on regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of fat cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of histone deacetylation. Located in nucleus. Is expressed in several structures, including blood island; central nervous system; genitourinary system; musculoskeletal system; and neural retina. Orthologous to human JDP2 (Jun dimerization protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 10.5), limb E14.5 (RPKM 9.3) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Jdp2 in Genome Data Viewer
Location:
12 D2; 12 39.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85645190..85686652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85598656..85639878)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32296 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86912459-86912666 Neighboring gene predicted gene, 32348 Neighboring gene STARR-positive B cell enhancer ABC_E3062 Neighboring gene STARR-seq mESC enhancer starr_32783 Neighboring gene predicted gene, 33312 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:87002012-87002121 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:87027519-87027764 Neighboring gene basic leucine zipper transcription factor, ATF-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP response element binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone chaperone activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables leucine zipper domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
jun dimerization protein 2
Names
c-Jun dimerization protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205052.2NP_001191981.1  jun dimerization protein 2

    See identical proteins and their annotated locations for NP_001191981.1

    Status: VALIDATED

    Source sequence(s)
    AC115037
    Consensus CDS
    CCDS26060.1
    UniProtKB/Swiss-Prot
    P97875
    UniProtKB/TrEMBL
    Q9EQX5
    Related
    ENSMUSP00000136823.2, ENSMUST00000177587.9
    Conserved Domains (3) summary
    cd14686
    Location:82132
    bZIP; coiled coil [structural motif]
    cl21453
    Location:1861
    PKc_like; Protein Kinases, catalytic domain
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  2. NM_001205053.2NP_001191982.1  jun dimerization protein 2

    See identical proteins and their annotated locations for NP_001191982.1

    Status: VALIDATED

    Source sequence(s)
    AC115037
    Consensus CDS
    CCDS26060.1
    UniProtKB/Swiss-Prot
    P97875
    UniProtKB/TrEMBL
    Q9EQX5
    Related
    ENSMUSP00000129985.3, ENSMUST00000171754.3
    Conserved Domains (3) summary
    cd14686
    Location:82132
    bZIP; coiled coil [structural motif]
    cl21453
    Location:1861
    PKc_like; Protein Kinases, catalytic domain
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  3. NM_001401266.1NP_001388195.1  jun dimerization protein 2

    Status: VALIDATED

    Source sequence(s)
    AC115037
    UniProtKB/Swiss-Prot
    P97875
    UniProtKB/TrEMBL
    Q9EQX5
  4. NM_030887.3NP_112149.2  jun dimerization protein 2

    See identical proteins and their annotated locations for NP_112149.2

    Status: VALIDATED

    Source sequence(s)
    AC115037
    Consensus CDS
    CCDS26060.1
    UniProtKB/Swiss-Prot
    P97875
    UniProtKB/TrEMBL
    Q9EQX5
    Related
    ENSMUSP00000059724.7, ENSMUST00000050687.14
    Conserved Domains (3) summary
    cd14686
    Location:82132
    bZIP; coiled coil [structural motif]
    cl21453
    Location:1861
    PKc_like; Protein Kinases, catalytic domain
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    85645190..85686652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244218.2XP_011242520.1  jun dimerization protein 2 isoform X1

    Conserved Domains (2) summary
    cd14722
    Location:205258
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
    cl21453
    Location:128171
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036157688.1XP_036013581.1  jun dimerization protein 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:128171
    PKc_like; Protein Kinases, catalytic domain