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JDP2 Jun dimerization protein 2 [ Homo sapiens (human) ]

Gene ID: 122953, updated on 13-Mar-2020

Summary

Official Symbol
JDP2provided by HGNC
Official Full Name
Jun dimerization protein 2provided by HGNC
Primary source
HGNC:HGNC:17546
See related
Ensembl:ENSG00000140044 MIM:608657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JUNDM2
Expression
Ubiquitous expression in spleen (RPKM 5.0), bone marrow (RPKM 4.2) and 25 other tissues See more
Orthologs

Genomic context

See JDP2 in Genome Data Viewer
Location:
14q24.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (75426692..75474107)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75894509..75939404)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1220 Neighboring gene developmental pluripotency associated 5 pseudogene 4 Neighboring gene uncharacterized LOC101928377 Neighboring gene uncharacterized LOC105370572 Neighboring gene basic leucine zipper ATF-like transcription factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of periodontal pathogen colonization.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
jun dimerization protein 2
Names
progesterone receptor co-activator

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135047.2NP_001128519.1  jun dimerization protein 2 isoform a

    See identical proteins and their annotated locations for NP_001128519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC009363, AF111167, AI916777, BC051303, BU740697
    Consensus CDS
    CCDS9842.1
    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Related
    ENSP00000415558.2, ENST00000419727.6
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  2. NM_001135048.2NP_001128520.1  jun dimerization protein 2 isoform a

    See identical proteins and their annotated locations for NP_001128520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC009363, AF111167, BC051303, BE389064, BU740697
    Consensus CDS
    CCDS9842.1
    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Related
    ENSP00000498745.1, ENST00000651602.1
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  3. NM_001135049.1NP_001128521.1  jun dimerization protein 2 isoform b

    See identical proteins and their annotated locations for NP_001128521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC009363, BC051303, BU740697
    Consensus CDS
    CCDS45139.1
    UniProtKB/Swiss-Prot
    Q8WYK2
    Related
    ENSP00000267569.5, ENST00000267569.5
    Conserved Domains (1) summary
    cd14722
    Location:93146
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
  4. NM_130469.3NP_569736.1  jun dimerization protein 2 isoform a

    See identical proteins and their annotated locations for NP_569736.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longest transcript and encodes the shorter isoform (a). Variants 1, 2 and 3 encode the same isoform.
    Source sequence(s)
    AC009363, BC051303, BC068196, BU740697
    Consensus CDS
    CCDS9842.1
    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Related
    ENSP00000399587.2, ENST00000435893.6
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    75426692..75474107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020975.2XP_016876464.1  jun dimerization protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  2. XM_017020973.1XP_016876462.1  jun dimerization protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  3. XM_017020974.1XP_016876463.1  jun dimerization protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  4. XM_017020972.1XP_016876461.1  jun dimerization protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8WYK2
    Conserved Domains (1) summary
    cd14722
    Location:93146
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
  5. XM_005267332.4XP_005267389.1  jun dimerization protein 2 isoform X3

    See identical proteins and their annotated locations for XP_005267389.1

    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  6. XM_017020976.1XP_016876465.1  jun dimerization protein 2 isoform X4

  7. XM_017020971.1XP_016876460.1  jun dimerization protein 2 isoform X1

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