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JDP2 Jun dimerization protein 2 [ Homo sapiens (human) ]

Gene ID: 122953, updated on 13-Mar-2020

Summary

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Official Symbol
JDP2provided by HGNC
Official Full Name
Jun dimerization protein 2provided by HGNC
Primary source
HGNC:HGNC:17546
See related
Ensembl:ENSG00000140044 MIM:608657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JUNDM2
Expression
Ubiquitous expression in spleen (RPKM 5.0), bone marrow (RPKM 4.2) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See JDP2 in Genome Data Viewer
Location:
14q24.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (75426692..75474107)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75894509..75939404)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1220 Neighboring gene developmental pluripotency associated 5 pseudogene 4 Neighboring gene uncharacterized LOC101928377 Neighboring gene uncharacterized LOC105370572 Neighboring gene basic leucine zipper ATF-like transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The expression of a tumor suppressor gene JDP2 and its prognostic value in hepatocellular carcinoma patients. Chen YL, et al. Hum Pathol, 2017 May. PMID 28315425
  2. Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells. Calicchio R, et al. Am J Pathol, 2013 Dec. PMID 24120378
  3. Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency. Murata T, et al. J Biol Chem, 2011 Jun 24. PMID 21525011, Free PMC Article
  4. Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging. Huang YC, et al. Kaohsiung J Med Sci, 2010 Oct. PMID 20950777
  5. Downregulation of AP-1 repressor JDP2 is associated with tumor metastasis and poor prognosis in patients with pancreatic carcinoma. Yuanhong X, et al. Int J Biol Markers, 2010 Jul-Sep. PMID 20677166

See all (39) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. JDP2 is downregulated in HCC tissues and cells, and overexpressed JDP2 facilitated HCC cell invasion and EMT.
    Title: miR-501 acts as an independent prognostic factor that promotes the epithelial-mesenchymal transition through targeting JDP2 in hepatocellular carcinoma.
  2. These studies establish JDP2 as a novel oncogene in high-risk T cell acute lymphoblastic leukemia.
    Title: JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.
  3. JDP2 was downregulated in myelodysplastic syndrome. Its expression was inversely related to disease aggressiveness and AML transformation. JDP2 suppression is a direct result of reduced PU.1. PU.1 and JDP2 expression correlate and are concurrently reduced with the extent of differentiation arrest and aggression/prognosis in MDS/AML. It was upregulated upon azacytidine treatment.
    Title: Using PU.1 and Jun dimerization protein 2 transcription factor expression in myelodysplastic syndromes to predict treatment response and leukaemia transformation.
  4. In hepatocellular carcinoma, high expression of JDP2 is significantly correlated with smaller tumor size, early stage HCC and better survival.
    Title: The expression of a tumor suppressor gene JDP2 and its prognostic value in hepatocellular carcinoma patients.
  5. Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells.
    Title: Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells.
  6. Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE.
    Title: Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.
  7. the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism.
    Title: The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.
  8. The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed.
    Title: Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging.
  9. JDP2 is crucial to triggering reactivation from latency to lytic replication
    Title: Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency.
  10. 3 SNPs (2 intronic: rs741846 & rs175646; & 1 in the untranslated region: rs8215) & their genotype distribution showed significant association in the Japanese & Korean but not Dutch intracranial aneurysm patients.
    Title: Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide association study of periodontal pathogen colonization.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
 PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
  
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
jun dimerization protein 2
Names
progesterone receptor co-activator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135047.2 → NP_001128519.1  jun dimerization protein 2 isoform a

    See identical proteins and their annotated locations for NP_001128519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC009363, AF111167, AI916777, BC051303, BU740697
    Consensus CDS
    CCDS9842.1
    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Related
    ENSP00000415558.2, ENST00000419727.6
    Conserved Domains (2) summary
    cd14686
    Location:82 → 126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82 → 135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  2. NM_001135048.2 → NP_001128520.1  jun dimerization protein 2 isoform a

    See identical proteins and their annotated locations for NP_001128520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC009363, AF111167, BC051303, BE389064, BU740697
    Consensus CDS
    CCDS9842.1
    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Related
    ENSP00000498745.1, ENST00000651602.1
    Conserved Domains (2) summary
    cd14686
    Location:82 → 126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82 → 135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  3. NM_001135049.1 → NP_001128521.1  jun dimerization protein 2 isoform b

    See identical proteins and their annotated locations for NP_001128521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC009363, BC051303, BU740697
    Consensus CDS
    CCDS45139.1
    UniProtKB/Swiss-Prot
    Q8WYK2
    Related
    ENSP00000267569.5, ENST00000267569.5
    Conserved Domains (1) summary
    cd14722
    Location:93 → 146
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

  4. NM_130469.3 → NP_569736.1  jun dimerization protein 2 isoform a

    See identical proteins and their annotated locations for NP_569736.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longest transcript and encodes the shorter isoform (a). Variants 1, 2 and 3 encode the same isoform.
    Source sequence(s)
    AC009363, BC051303, BC068196, BU740697
    Consensus CDS
    CCDS9842.1
    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Related
    ENSP00000399587.2, ENST00000435893.6
    Conserved Domains (2) summary
    cd14686
    Location:82 → 126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82 → 135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    75426692..75474107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020975.2 → XP_016876464.1  jun dimerization protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Conserved Domains (2) summary
    cd14686
    Location:82 → 126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82 → 135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  2. XM_017020973.1 → XP_016876462.1  jun dimerization protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Conserved Domains (2) summary
    cd14686
    Location:82 → 126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82 → 135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  3. XM_017020974.1 → XP_016876463.1  jun dimerization protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Conserved Domains (2) summary
    cd14686
    Location:82 → 126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82 → 135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  4. XM_017020972.1 → XP_016876461.1  jun dimerization protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8WYK2
    Conserved Domains (1) summary
    cd14722
    Location:93 → 146
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

  5. XM_005267332.4 → XP_005267389.1  jun dimerization protein 2 isoform X3

    See identical proteins and their annotated locations for XP_005267389.1

    UniProtKB/Swiss-Prot
    Q8WYK2
    UniProtKB/TrEMBL
    A0A024R6D7
    Conserved Domains (2) summary
    cd14686
    Location:82 → 126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82 → 135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  6. XM_017020976.1 → XP_016876465.1  jun dimerization protein 2 isoform X4

  7. XM_017020971.1 → XP_016876460.1  jun dimerization protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WYK2.1 GenPept UniProtKB/Swiss-Prot:Q8WYK2

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