U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

JDP2 Jun dimerization protein 2 [ Homo sapiens (human) ]

Gene ID: 122953, updated on 11-Jun-2025
Official Symbol
JDP2provided by HGNC
Official Full Name
Jun dimerization protein 2provided by HGNC
Primary source
HGNC:HGNC:17546
See related
Ensembl:ENSG00000140044 MIM:608657; AllianceGenome:HGNC:17546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JUNDM2
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in spleen (RPKM 5.0), bone marrow (RPKM 4.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See JDP2 in Genome Data Viewer
Location:
14q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (75426943..75474107)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69637134..69683532)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75894427..75940810)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5944 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36717 Neighboring gene long intergenic non-protein coding RNA 1220 Neighboring gene developmental pluripotency associated 5 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75800727-75801226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75894221-75894778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5947 Neighboring gene JDP2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75904146-75904649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75905657-75906159 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75907363-75908346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75918700-75919214 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75919215-75919730 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75919731-75920244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75925593-75926141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75941017-75941518 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75946817-75947707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75980965-75981530 Neighboring gene uncharacterized LOC105370572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8753 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:76004983-76005197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8756 Neighboring gene basic leucine zipper ATF-like transcription factor

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide association study of periodontal pathogen colonization.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables cAMP response element binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables histone chaperone activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
enables leucine zipper domain binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex EXP
Inferred from Experiment
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus EXP
Inferred from Experiment
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
jun dimerization protein 2
Names
progesterone receptor co-activator

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135047.2NP_001128519.1  jun dimerization protein 2 isoform a

    See identical proteins and their annotated locations for NP_001128519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC009363, AF111167, AI916777, BC051303, BU740697
    Consensus CDS
    CCDS9842.1
    UniProtKB/Swiss-Prot
    J3KN58, O95430, Q8WYK2, Q9UIE4
    UniProtKB/TrEMBL
    H0YKE4
    Related
    ENSP00000415558.2, ENST00000419727.6
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  2. NM_001135048.2NP_001128520.1  jun dimerization protein 2 isoform a

    See identical proteins and their annotated locations for NP_001128520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC009363, AF111167, BC051303, BE389064, BU740697
    Consensus CDS
    CCDS9842.1
    UniProtKB/Swiss-Prot
    J3KN58, O95430, Q8WYK2, Q9UIE4
    UniProtKB/TrEMBL
    H0YKE4
    Related
    ENSP00000498745.1, ENST00000651602.1
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  3. NM_001135049.1NP_001128521.1  jun dimerization protein 2 isoform b

    See identical proteins and their annotated locations for NP_001128521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC009363, BC051303, BU740697
    Consensus CDS
    CCDS45139.1
    UniProtKB/Swiss-Prot
    Q8WYK2
    Related
    ENSP00000267569.5, ENST00000267569.5
    Conserved Domains (1) summary
    cd14722
    Location:93146
    bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
  4. NM_130469.3NP_569736.1  jun dimerization protein 2 isoform a

    See identical proteins and their annotated locations for NP_569736.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longest transcript and encodes the shorter isoform (a). Variants 1, 2 and 3 encode the same isoform.
    Source sequence(s)
    AC009363, BC051303, BC068196, BU740697
    Consensus CDS
    CCDS9842.1
    UniProtKB/Swiss-Prot
    J3KN58, O95430, Q8WYK2, Q9UIE4
    UniProtKB/TrEMBL
    H0YKE4
    Related
    ENSP00000399587.2, ENST00000435893.6
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    75426943..75474107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020973.2XP_016876462.1  jun dimerization protein 2 isoform X3

    UniProtKB/Swiss-Prot
    J3KN58, O95430, Q8WYK2, Q9UIE4
    UniProtKB/TrEMBL
    H0YKE4
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  2. XM_047430942.1XP_047286898.1  jun dimerization protein 2 isoform X1

  3. XM_047430944.1XP_047286900.1  jun dimerization protein 2 isoform X2

  4. XM_047430943.1XP_047286899.1  jun dimerization protein 2 isoform X2

  5. XM_005267332.5XP_005267389.1  jun dimerization protein 2 isoform X3

    See identical proteins and their annotated locations for XP_005267389.1

    UniProtKB/Swiss-Prot
    J3KN58, O95430, Q8WYK2, Q9UIE4
    UniProtKB/TrEMBL
    H0YKE4
    Conserved Domains (2) summary
    cd14686
    Location:82126
    bZIP; coiled coil [structural motif]
    cl21462
    Location:82135
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    69637134..69683532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375399.1XP_054231374.1  jun dimerization protein 2 isoform X1

  2. XM_054375401.1XP_054231376.1  jun dimerization protein 2 isoform X2

  3. XM_054375400.1XP_054231375.1  jun dimerization protein 2 isoform X2

  4. XM_054375402.1XP_054231377.1  jun dimerization protein 2 isoform X3

    UniProtKB/Swiss-Prot
    J3KN58, O95430, Q8WYK2, Q9UIE4
    UniProtKB/TrEMBL
    H0YKE4