JDP2 Jun dimerization protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: JDP2provided by HGNC
Official Full Name: Jun dimerization protein 2provided by HGNC
Primary source: HGNC:HGNC:17546
See related: Ensembl:ENSG00000140044 MIM:608657; AllianceGenome:HGNC:17546
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JUNDM2
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen (RPKM 5.0), bone marrow (RPKM 4.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q24.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (75426943..75474107)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (69637134..69683532)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (75894427..75940810)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis.
Title: JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis.
Down-regulated lncRNA AGAP2-AS1 contributes to pre-eclampsia as a competing endogenous RNA for JDP2 by impairing trophoblastic phenotype.
Title: Down-regulated lncRNA AGAP2-AS1 contributes to pre-eclampsia as a competing endogenous RNA for JDP2 by impairing trophoblastic phenotype.
JDP2 is downregulated in HCC tissues and cells, and overexpressed JDP2 facilitated HCC cell invasion and EMT.
Title: miR-501 acts as an independent prognostic factor that promotes the epithelial-mesenchymal transition through targeting JDP2 in hepatocellular carcinoma.
These studies establish JDP2 as a novel oncogene in high-risk T cell acute lymphoblastic leukemia.
Title: JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.
JDP2 was downregulated in myelodysplastic syndrome. Its expression was inversely related to disease aggressiveness and AML transformation. JDP2 suppression is a direct result of reduced PU.1. PU.1 and JDP2 expression correlate and are concurrently reduced with the extent of differentiation arrest and aggression/prognosis in MDS/AML. It was upregulated upon azacytidine treatment.
Title: Using PU.1 and Jun dimerization protein 2 transcription factor expression in myelodysplastic syndromes to predict treatment response and leukaemia transformation.
In hepatocellular carcinoma, high expression of JDP2 is significantly correlated with smaller tumor size, early stage HCC and better survival.
Title: The expression of a tumor suppressor gene JDP2 and its prognostic value in hepatocellular carcinoma patients.
Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells.
Title: Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells.
Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE.
Title: Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.
the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism.
Title: The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.
The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed.
Title: Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of periodontal pathogen colonization. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G10731 (e-PCR)
- UniSTS:59138

G43530 (e-PCR)
- UniSTS:94987

SHGC-145231 (e-PCR)
- UniSTS:174459

RH48884 (e-PCR)
- UniSTS:9603

WI-17116 (e-PCR)
- UniSTS:3823

Homology

Homologs of the JDP2 gene: The JDP2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 393 organisms have orthologs with human gene JDP2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cAMP response element binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables leucine zipper domain binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	EXP Inferred from Experiment more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of histone deacetylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	EXP Inferred from Experiment more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleus	EXP Inferred from Experiment more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: jun dimerization protein 2

Names: progesterone receptor co-activator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135047.2 → NP_001128519.1 jun dimerization protein 2 isoform a

See identical proteins and their annotated locations for NP_001128519.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).

Source sequence(s)

AC009363, AF111167, AI916777, BC051303, BU740697

Consensus CDS

CCDS9842.1

UniProtKB/Swiss-Prot

Q8WYK2, Q9UIE4

UniProtKB/TrEMBL

A0A024R6D7

Related

ENSP00000415558.2, ENST00000419727.6

Conserved Domains (2) summary

cd14686
Location:82 → 126

bZIP; coiled coil [structural motif]

cl21462
Location:82 → 135

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
NM_001135048.2 → NP_001128520.1 jun dimerization protein 2 isoform a

See identical proteins and their annotated locations for NP_001128520.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).

Source sequence(s)

AC009363, AF111167, BC051303, BE389064, BU740697

Consensus CDS

CCDS9842.1

UniProtKB/Swiss-Prot

Q8WYK2, Q9UIE4

UniProtKB/TrEMBL

A0A024R6D7

Related

ENSP00000498745.1, ENST00000651602.1

Conserved Domains (2) summary

cd14686
Location:82 → 126

bZIP; coiled coil [structural motif]

cl21462
Location:82 → 135

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
NM_001135049.1 → NP_001128521.1 jun dimerization protein 2 isoform b

See identical proteins and their annotated locations for NP_001128521.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.

Source sequence(s)

AC009363, BC051303, BU740697

Consensus CDS

CCDS45139.1

UniProtKB/Swiss-Prot

Q8WYK2

Related

ENSP00000267569.5, ENST00000267569.5

Conserved Domains (1) summary

cd14722
Location:93 → 146

bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
NM_130469.3 → NP_569736.1 jun dimerization protein 2 isoform a

See identical proteins and their annotated locations for NP_569736.1

Status: VALIDATED

Description

Transcript Variant: This variant represents the longest transcript and encodes the shorter isoform (a). Variants 1, 2 and 3 encode the same isoform.

Source sequence(s)

AC009363, BC051303, BC068196, BU740697

Consensus CDS

CCDS9842.1

UniProtKB/Swiss-Prot

Q8WYK2, Q9UIE4

UniProtKB/TrEMBL

A0A024R6D7

Related

ENSP00000399587.2, ENST00000435893.6

Conserved Domains (2) summary

cd14686
Location:82 → 126

bZIP; coiled coil [structural motif]

cl21462
Location:82 → 135

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

75426943..75474107

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017020973.2 → XP_016876462.1 jun dimerization protein 2 isoform X3

UniProtKB/Swiss-Prot

Q8WYK2, Q9UIE4

UniProtKB/TrEMBL

A0A024R6D7

Conserved Domains (2) summary

cd14686
Location:82 → 126

bZIP; coiled coil [structural motif]

cl21462
Location:82 → 135

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
XM_047430942.1 → XP_047286898.1 jun dimerization protein 2 isoform X1
XM_047430944.1 → XP_047286900.1 jun dimerization protein 2 isoform X2
XM_047430943.1 → XP_047286899.1 jun dimerization protein 2 isoform X2
XM_005267332.5 → XP_005267389.1 jun dimerization protein 2 isoform X3

See identical proteins and their annotated locations for XP_005267389.1

UniProtKB/Swiss-Prot

Q8WYK2, Q9UIE4

UniProtKB/TrEMBL

A0A024R6D7

Conserved Domains (2) summary

cd14686
Location:82 → 126

bZIP; coiled coil [structural motif]

cl21462
Location:82 → 135

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain