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TIM [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816652, updated on 22-Aug-2024

Summary

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Official Symbol
TIM
Primary source
Araport:AT2G21170
Locus tag
AT2G21170
See related
TAIR:AT2G21170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F26H11.7; F26H11_7; PDTPI; PLASTID ISOFORM TRIOSE PHOSPHATE ISOMERASE; triosephosphate isomerase; TRIOSEPHOSPHATE ISOMERASE
Summary
Encodes a plastidic triose phosphate isomerase. Mutants with reduced pdTPI levels have difficulty transitioning from heterotrophic to autotrophic growth. The related phenotypes, such as chlorosis in light-grown seedlings may result from an accumulation of dihydroxyacetone phosphate (DHAP) and methylglyoxal (MG) in these mutants. Both splice variants appear to be expressed, but the At2g21170.2 variant appears to have a much narrower expression range limited to roots.
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Genomic context

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Location:
chromosome: 2
Exon count:
10
Sequence:
Chromosome: 2; NC_003071.7 (9070734..9074470, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene XAP5 family protein Neighboring gene Translocon-associated protein (TRAP), alpha subunit Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The plastid isoform of triose phosphate isomerase is required for the postgerminative transition from heterotrophic to autotrophic growth in Arabidopsis. Chen M, et al. Plant Cell, 2010 Jan. PMID 20097871, Free PMC Article
  2. High light response of the thylakoid proteome in arabidopsis wild type and the ascorbate-deficient mutant vtc2-2. A comparative proteomics study. Giacomelli L, et al. Plant Physiol, 2006 Jun. PMID 16648217, Free PMC Article
  3. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
  4. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
  5. Isolation and identification of ubiquitin-related proteins from Arabidopsis seedlings. Igawa T, et al. J Exp Bot, 2009. PMID 19429840, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001084462.1
NM_001335732.1
NM_127687.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables triose-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables triose-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloroplast organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glyceraldehyde-3-phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycerol catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organismal reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within primary root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reductive pentose-phosphate cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within triglyceride mobilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in thylakoid HDA PubMed 

General protein information

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Preferred Names
triosephosphate isomerase
NP_001077931.1
  • triosephosphate isomerase (TIM); FUNCTIONS IN: triose-phosphate isomerase activity; INVOLVED IN: in 7 processes; LOCATED IN: thylakoid, mitochondrion, apoplast, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Triosephosphate isomerase, active site (InterPro:IPR020861), Aldolase-type TIM barrel (InterPro:IPR013785), Triosephosphate isomerase (InterPro:IPR000652); BEST Arabidopsis thaliana protein match is: triosephosphate isomerase (TAIR:AT3G55440.1); Has 11527 Blast hits to 11525 proteins in 3623 species: Archae - 144; Bacteria - 6185; Metazoa - 1204; Fungi - 240; Plants - 472; Viruses - 0; Other Eukaryotes - 3282 (source: NCBI BLink).
NP_179713.1
  • triosephosphate isomerase (TIM); FUNCTIONS IN: triose-phosphate isomerase activity; INVOLVED IN: in 7 processes; LOCATED IN: in 6 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Triosephosphate isomerase, active site (InterPro:IPR020861), Aldolase-type TIM barrel (InterPro:IPR013785), Triosephosphate isomerase (InterPro:IPR000652); BEST Arabidopsis thaliana protein match is: triosephosphate isomerase (TAIR:AT3G55440.1); Has 11587 Blast hits to 11585 proteins in 3635 species: Archae - 138; Bacteria - 6210; Metazoa - 1207; Fungi - 243; Plants - 472; Viruses - 0; Other Eukaryotes - 3317 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    9070734..9074470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127687.4 → NP_179713.1  triosephosphate isomerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_179713.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SKP6
    UniProtKB/TrEMBL
    A0A178VN28, A0A5S9WZU4
    Conserved Domains (1) summary
    PLN02429
    Location:1 → 315
    PLN02429; triosephosphate isomerase

  2. NM_001335732.1 → NP_001323967.1  triosephosphate isomerase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SKP6
    UniProtKB/TrEMBL
    A0A178VN28, A0A5S9WZU4
    Conserved Domains (1) summary
    PLN02429
    Location:1 → 315
    PLN02429; triosephosphate isomerase

  3. NM_001084462.1 → NP_001077931.1  triosephosphate isomerase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077931.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8MRE8
    Conserved Domains (1) summary
    PLN02429
    Location:1 → 306
    PLN02429; triosephosphate isomerase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SKP6.1

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