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Chrm2 cholinergic receptor, muscarinic 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81645, updated on 11-Apr-2024

Summary

Symbol
Chrm2provided by RGD
Full Name
cholinergic receptor, muscarinic 2provided by RGD
Primary source
RGD:620023
See related
Ensembl:ENSRNOG00000046972 AllianceGenome:RGD:620023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acm2
Summary
Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and regulation of smooth muscle contraction. Located in several cellular components, including asymmetric synapse; neuronal cell body; and symmetric synapse. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of mental depression. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Chrm2 in Genome Data Viewer
Location:
4q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (65981136..66116128)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (65015408..65149104)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (64089028..64091090)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RHEB like 1, pseudogene 1 Neighboring gene uncharacterized LOC102554507 Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA 490 Neighboring gene pleiotrophin Neighboring gene diacylglycerol kinase, iota

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arrestin family protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cholinergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in symmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
muscarinic acetylcholine receptor M2
Names
7TM receptor
M2 muscarinic acetylcholine receptor
cholinergic receptor, muscarinic 2, cardiac
muscarinic acetylcholine receptor M2-like
muscarinic receptor m2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031016.2NP_112278.2  muscarinic acetylcholine receptor M2

    Status: VALIDATED

    Source sequence(s)
    AY571965, JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P10980, Q9Z2Z1
    UniProtKB/TrEMBL
    A6IEP6
    Related
    ENSRNOP00000082007.1, ENSRNOT00000115807.1
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    65981136..66116128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286746.1XP_063142816.1  muscarinic acetylcholine receptor M2 isoform X1

    UniProtKB/Swiss-Prot
    P10980, Q9Z2Z1
    UniProtKB/TrEMBL
    A6IEP6
  2. XM_039108421.2XP_038964349.1  muscarinic acetylcholine receptor M2 isoform X1

    UniProtKB/Swiss-Prot
    P10980, Q9Z2Z1
    UniProtKB/TrEMBL
    A6IEP6
    Related
    ENSRNOP00000088860.1
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors