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CHRM2 cholinergic receptor muscarinic 2 [ Homo sapiens (human) ]

Gene ID: 1129, updated on 11-Jun-2021

Summary

Official Symbol
CHRM2provided by HGNC
Official Full Name
cholinergic receptor muscarinic 2provided by HGNC
Primary source
HGNC:HGNC:1951
See related
Ensembl:ENSG00000181072 MIM:118493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HM2
Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 10.8), gall bladder (RPKM 5.9) and 3 other tissues See more
Orthologs
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Genomic context

See CHRM2 in Genome Data Viewer
Location:
7q33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (136868652..137020213)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (136553399..136704960)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375524 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 3 Neighboring gene uncharacterized LOC349160 Neighboring gene microRNA 490 Neighboring gene keratin 8 pseudogene 51 Neighboring gene uncharacterized LOC105375525 Neighboring gene ribosomal protein L18 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
GeneReviews: Not available
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43243, MGC120006, MGC120007

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arrestin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in membrane organization TAS
Traceable Author Statement
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
muscarinic acetylcholine receptor M2
Names
7TM receptor
acetylcholine receptor, muscarinic 2
muscarinic M2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011846.2 RefSeqGene

    Range
    5001..153373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_405

mRNA and Protein(s)

  1. NM_000739.3NP_000730.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_000730.1

    Status: REVIEWED

    Source sequence(s)
    AC009264, AC020581, KF458615
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001006626.3NP_001006627.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006627.1

    Status: REVIEWED

    Source sequence(s)
    AC009264, AC020581, KF458615
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Related
    ENSP00000384401.1, ENST00000401861.1
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001006627.3NP_001006628.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006628.1

    Status: REVIEWED

    Source sequence(s)
    AC009264, AC020581, KF458615
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Related
    ENSP00000399745.2, ENST00000445907.6
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001006628.3NP_001006629.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006629.1

    Status: REVIEWED

    Source sequence(s)
    AC009264, AC020581, KF458615
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_001006629.3NP_001006630.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006630.1

    Status: REVIEWED

    Source sequence(s)
    AC009264, AC020581, KF458615
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. NM_001006630.2NP_001006631.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006631.1

    Status: REVIEWED

    Source sequence(s)
    AC009264, AC020581, KF458615
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Related
    ENSP00000505686.1, ENST00000680005.1
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. NM_001006631.3NP_001006632.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006632.1

    Status: REVIEWED

    Source sequence(s)
    AC009264, AC020581, KF458615
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q6SL59
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. NM_001006632.3NP_001006633.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006633.1

    Status: REVIEWED

    Source sequence(s)
    AC009264, AC020581, KF458615
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q6SL59
    Related
    ENSP00000319984.5, ENST00000320658.9
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors
  9. NM_001378972.1NP_001365901.1  muscarinic acetylcholine receptor M2

    Status: REVIEWED

    Source sequence(s)
    AC009264, AC020581, KF458615
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors
  10. NM_001378973.1NP_001365902.1  muscarinic acetylcholine receptor M2

    Status: REVIEWED

    Source sequence(s)
    AC009264, AC020581, KF458615
    Related
    ENSP00000415386.1, ENST00000453373.5
    Conserved Domains (1) summary
    cd15297
    Location:24451
    7tmA_mAChR_M2; muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    136868652..137020213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006633.1: Suppressed sequence

    Description
    NM_001006633.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.
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