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URM1 ubiquitin related modifier 1 [ Homo sapiens (human) ]

Gene ID: 81605, updated on 12-Oct-2019

Summary

Official Symbol
URM1provided by HGNC
Official Full Name
ubiquitin related modifier 1provided by HGNC
Primary source
HGNC:HGNC:28378
See related
Ensembl:ENSG00000167118 MIM:612693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf74
Expression
Ubiquitous expression in spleen (RPKM 8.1), lymph node (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See URM1 in Genome Data Viewer
Location:
9q34.11
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128371319..128392016)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131133598..131154295)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene tRNA-Arg (anticodon TCT) 3-1 Neighboring gene solute carrier family 27 member 4 Neighboring gene TMSB4X pseudogene 4 Neighboring gene microRNA 219a-2 Neighboring gene microRNA 219b Neighboring gene cerebral endothelial cell adhesion molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Sulfur relay system, organism-specific biosystem (from KEGG)
    Sulfur relay system, organism-specific biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...
  • Sulfur relay system, conserved biosystem (from KEGG)
    Sulfur relay system, conserved biosystemUbiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein mod...
  • tRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
    tRNA modification in the nucleus and cytosol, organism-specific biosystemAt least 92 distinct tRNA nucleotide base modifications have been found. The modifications are made post-transcriptionally by a large group of disparate enzymes located in the nucleus, cytosol, and m...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sulfur carrier activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein urmylation IEA
Inferred from Electronic Annotation
more info
 
tRNA modification TAS
Traceable Author Statement
more info
 
tRNA thio-modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IC
Inferred by Curator
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ubiquitin-related modifier 1
Names
ubiquitin-related modifier 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135947.2NP_001129419.1  ubiquitin-related modifier 1 isoform b

    See identical proteins and their annotated locations for NP_001129419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (B)
    Source sequence(s)
    AK300877, AL359091, BI823604
    Consensus CDS
    CCDS48035.1
    UniProtKB/Swiss-Prot
    Q9BTM9
    Related
    ENSP00000412922.1, ENST00000452446.2
    Conserved Domains (1) summary
    pfam09138
    Location:679
    Urm1; Urm1 (Ubiquitin related modifier)
  2. NM_001265582.1NP_001252511.1  ubiquitin-related modifier 1 isoform c

    See identical proteins and their annotated locations for NP_001252511.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional segment in the 3' end, compared to variant 2, which reults in a protein (isoform C) with a shorter C-terminus, compared to isoform B.
    Source sequence(s)
    AL359091, BC011620, BI823604
    Consensus CDS
    CCDS59148.1
    UniProtKB/Swiss-Prot
    Q9BTM9
    Related
    ENSP00000361941.1, ENST00000372850.5
    Conserved Domains (1) summary
    cl25424
    Location:663
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...
  3. NM_030914.4NP_112176.1  ubiquitin-related modifier 1 isoform a

    See identical proteins and their annotated locations for NP_112176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks a segment in the 3' coding region, compared to variant 2, which results in a protein (isoform 1) with a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AL359091, BC003581
    Consensus CDS
    CCDS6900.1
    UniProtKB/Swiss-Prot
    Q9BTM9
    UniProtKB/TrEMBL
    A0A024R8C7
    Related
    ENSP00000361944.4, ENST00000372853.8
    Conserved Domains (1) summary
    pfam09138
    Location:6101
    Urm1; Urm1 (Ubiquitin related modifier)

RNA

  1. NR_049743.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region, compared to variant 2, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significiantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL359091, DA691216

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128371319..128392016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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