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APOLD1 apolipoprotein L domain containing 1 [ Homo sapiens (human) ]

Gene ID: 81575, updated on 11-Jun-2021

Summary

Official Symbol
APOLD1provided by HGNC
Official Full Name
apolipoprotein L domain containing 1provided by HGNC
Primary source
HGNC:HGNC:25268
See related
Ensembl:ENSG00000178878 MIM:612456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VERGE
Summary
APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008]
Expression
Broad expression in fat (RPKM 54.0), thyroid (RPKM 52.1) and 18 other tissues See more
Orthologs
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Genomic context

See APOLD1 in Genome Data Viewer
Location:
12p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (12725917..12791466)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12878851..12944400)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 19 Neighboring gene uncharacterized LOC105369663 Neighboring gene uncharacterized LOC107984129 Neighboring gene cyclin dependent kinase inhibitor 1B Neighboring gene microRNA 613 Neighboring gene syntaxin 8 pseudogene 1 Neighboring gene DEAD-box helicase 47 Neighboring gene uncharacterized LOC107984492 Neighboring gene ribosomal protein L37a pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DDX47

Homology

Clone Names

  • FLJ25138, FLJ95166, DKFZp434F0318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of endothelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
apolipoprotein L domain-containing protein 1
Names
vascular early response gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130415.2NP_001123887.1  apolipoprotein L domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001123887.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007215, AK024963, BC042478, DC413327
    Consensus CDS
    CCDS44833.1
    UniProtKB/Swiss-Prot
    Q96LR9
    Related
    ENSP00000324277.6, ENST00000326765.10
    Conserved Domains (1) summary
    pfam05461
    Location:85138
    ApoL; Apolipoprotein L
  2. NM_030817.3NP_110444.3  apolipoprotein L domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_110444.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) contains a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC007215, AK024963, BC126433
    Consensus CDS
    CCDS8654.1
    UniProtKB/Swiss-Prot
    Q96LR9
    UniProtKB/TrEMBL
    A0AVN6
    Related
    ENSP00000348998.4, ENST00000356591.5
    Conserved Domains (1) summary
    pfam05461
    Location:54107
    ApoL; Apolipoprotein L

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    12725917..12791466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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