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STMN4 stathmin 4 [ Homo sapiens (human) ]

Gene ID: 81551, updated on 1-Mar-2024

Summary

Official Symbol
STMN4provided by HGNC
Official Full Name
stathmin 4provided by HGNC
Primary source
HGNC:HGNC:16078
See related
Ensembl:ENSG00000015592 MIM:620740; AllianceGenome:HGNC:16078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RB3
Summary
Predicted to enable tubulin binding activity. Predicted to be involved in microtubule depolymerization; neuron projection development; and regulation of microtubule polymerization or depolymerization. Predicted to be located in Golgi apparatus and growth cone. Predicted to be active in cytoplasm and neuron projection. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward brain (RPKM 50.0) See more
Orthologs
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Genomic context

See STMN4 in Genome Data Viewer
Location:
8p21.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27235308..27258404, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (27512166..27535258, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27092825..27115921, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 548h-4 Neighboring gene MPRA-validated peak6966 silencer Neighboring gene uncharacterized LOC105379340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27093978-27094478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27094479-27094979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27099673-27100624 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:27132319-27132821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27133 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27132 Neighboring gene tripartite motif containing 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27183969-27184798 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:27184956-27185152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19048 Neighboring gene Sharpr-MPRA regulatory region 9089 Neighboring gene protein tyrosine kinase 2 beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27141 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27219644-27220174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27153 Neighboring gene Sharpr-MPRA regulatory region 13363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27287852-27288568 Neighboring gene microRNA 6842

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC111012

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
stathmin-4
Names
stathmin-like 4
stathmin-like protein B3
stathmin-like-protein RB3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001283053.2NP_001269982.1  stathmin-4 isoform 2

    See identical proteins and their annotated locations for NP_001269982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC090150, AI638208, AK297415
    Consensus CDS
    CCDS64854.1
    UniProtKB/Swiss-Prot
    Q9H169
    Related
    ENSP00000428428.1, ENST00000523048.5
    Conserved Domains (1) summary
    pfam00836
    Location:76203
    Stathmin; Stathmin family
  2. NM_001283054.2NP_001269983.1  stathmin-4 isoform 3

    See identical proteins and their annotated locations for NP_001269983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1.
    Source sequence(s)
    AC090150, AI638208, BC111001
    Consensus CDS
    CCDS64852.1
    UniProtKB/Swiss-Prot
    B7Z2Z7, B7Z4I9, D3DSS8, D3DSS9, G5EA16, Q2TAB9, Q9H169
    Related
    ENSP00000265770.7, ENST00000265770.11
    Conserved Domains (1) summary
    pfam00836
    Location:49184
    Stathmin; Stathmin family
  3. NM_001283055.2NP_001269984.1  stathmin-4 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001269984.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in both UTR's and the coding region , compared to variant 1. This results in an isoform (4) that is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC090150, AI638208, AK295329
    Consensus CDS
    CCDS64851.1
    UniProtKB/Swiss-Prot
    Q9H169
    Related
    ENSP00000428474.1, ENST00000519997.5
    Conserved Domains (1) summary
    pfam00836
    Location:40167
    Stathmin; Stathmin family
  4. NM_001394383.1NP_001381312.1  stathmin-4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090150
    Conserved Domains (1) summary
    pfam00836
    Location:48183
    Stathmin; Stathmin family
  5. NM_001394384.1NP_001381313.1  stathmin-4 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC090150
    Conserved Domains (1) summary
    pfam00836
    Location:40175
    Stathmin; Stathmin family
  6. NM_001394385.1NP_001381314.1  stathmin-4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC090150
    Conserved Domains (1) summary
    pfam00836
    Location:49176
    Stathmin; Stathmin family
  7. NM_001394386.1NP_001381315.1  stathmin-4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC090150
    Conserved Domains (1) summary
    pfam00836
    Location:17152
    Stathmin; Stathmin family
  8. NM_001394387.1NP_001381316.1  stathmin-4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC090150
  9. NM_001394388.1NP_001381317.1  stathmin-4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC090150
  10. NM_030795.4NP_110422.2  stathmin-4 isoform 1

    See identical proteins and their annotated locations for NP_110422.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC090150, AI638208, BC011520
    Consensus CDS
    CCDS6055.1
    UniProtKB/Swiss-Prot
    Q9H169
    Related
    ENSP00000342538.4, ENST00000350889.9
    Conserved Domains (1) summary
    pfam00836
    Location:76211
    Stathmin; Stathmin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    27235308..27258404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273652.5XP_005273709.1  stathmin-4 isoform X1

    UniProtKB/TrEMBL
    B7Z1W4, E7EVN3
    Related
    ENSP00000430389.1, ENST00000522908.1
    Conserved Domains (1) summary
    pfam00836
    Location:80201
    Stathmin; Stathmin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    27512166..27535258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361305.1XP_054217280.1  stathmin-4 isoform X1

    UniProtKB/TrEMBL
    B7Z1W4, E7EVN3