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STMN4 stathmin 4 [ Homo sapiens (human) ]

Gene ID: 81551, updated on 12-Aug-2018

Summary

Official Symbol
STMN4provided by HGNC
Official Full Name
stathmin 4provided by HGNC
Primary source
HGNC:HGNC:16078
See related
Ensembl:ENSG00000015592 Vega:OTTHUMG00000099461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RB3
Expression
Restricted expression toward brain (RPKM 50.0) See more
Orthologs

Genomic context

See STMN4 in Genome Data Viewer
Location:
8p21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (27235323..27258865, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27093814..27116382, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 548h-4 Neighboring gene uncharacterized LOC105379340 Neighboring gene tripartite motif containing 35 Neighboring gene protein tyrosine kinase 2 beta Neighboring gene microRNA 6842

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111012

Gene Ontology Provided by GOA

Function Evidence Code Pubs
tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
stathmin-4
Names
stathmin-like 4
stathmin-like protein B3
stathmin-like-protein RB3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001283053.1NP_001269982.1  stathmin-4 isoform 2

    See identical proteins and their annotated locations for NP_001269982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC090150, AI638208, AK297415
    Consensus CDS
    CCDS64854.1
    UniProtKB/Swiss-Prot
    Q9H169
    Related
    ENSP00000428428.1, OTTHUMP00000225148, ENST00000523048.5, OTTHUMT00000375942
    Conserved Domains (1) summary
    pfam00836
    Location:76198
    Stathmin; Stathmin family
  2. NM_001283054.1NP_001269983.1  stathmin-4 isoform 3

    See identical proteins and their annotated locations for NP_001269983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1.
    Source sequence(s)
    AC090150, AI638208, BC111001
    Consensus CDS
    CCDS64852.1
    UniProtKB/Swiss-Prot
    Q9H169
    Related
    ENSP00000265770.7, OTTHUMP00000225147, ENST00000265770.11, OTTHUMT00000375941
    Conserved Domains (1) summary
    pfam00836
    Location:49184
    Stathmin; Stathmin family
  3. NM_001283055.1NP_001269984.1  stathmin-4 isoform 4

    See identical proteins and their annotated locations for NP_001269984.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in both UTR's and the coding region , compared to variant 1. This results in an isoform (4) that is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC090150, AI638208, AK295329
    Consensus CDS
    CCDS64851.1
    UniProtKB/Swiss-Prot
    Q9H169
    Related
    ENSP00000428474.1, OTTHUMP00000225146, ENST00000519997.5, OTTHUMT00000375940
    Conserved Domains (1) summary
    pfam00836
    Location:40162
    Stathmin; Stathmin family
  4. NM_030795.3NP_110422.2  stathmin-4 isoform 1

    See identical proteins and their annotated locations for NP_110422.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC090150, AI638208, BC011520
    Consensus CDS
    CCDS6055.1
    UniProtKB/Swiss-Prot
    Q9H169
    Related
    ENSP00000342538.4, OTTHUMP00000125315, ENST00000350889.8, OTTHUMT00000216932
    Conserved Domains (1) summary
    pfam00836
    Location:76211
    Stathmin; Stathmin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    27235323..27258865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273655.5XP_005273712.1  stathmin-4 isoform X2

    See identical proteins and their annotated locations for XP_005273712.1

    Conserved Domains (1) summary
    pfam00836
    Location:49171
    Stathmin; Stathmin family
  2. XM_005273652.4XP_005273709.1  stathmin-4 isoform X1

    UniProtKB/TrEMBL
    E7EVN3
    Related
    ENSP00000430389.1, OTTHUMP00000225150, ENST00000522908.1, OTTHUMT00000375944
    Conserved Domains (1) summary
    pfam00836
    Location:80201
    Stathmin; Stathmin family

RNA

  1. XR_002956647.1 RNA Sequence

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