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PFS2 Homeodomain-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 814678, updated on 18-Sep-2024

Summary

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Official Symbol
PFS2
Official Full Name
Homeodomain-like superfamily protein
Primary source
TAIR:AT2G01500
Locus tag
AT2G01500
See related
Araport:AT2G01500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F2I9.12; F2I9_12; HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 9; HOS9; PRETTY FEW SEEDS 2; WOX6; WUSCHEL RELATED HOMEOBOX 6
Summary
PFS2 encodes a homeodomain gene that is a member of the WUS clade of transcription factors. It delays differentiation and maturation of primordia and regulates ovule patterning. The pfs2 mutant exhibits developmental defects in the maternal integuments and gametophyte, specifically, the boundary between the chalaza and the nucellus shifted towards the distal end of pfs2 ovule primordia. In addition, leaves displayed curling and petals were wavy and crenulated. Overexpression of PFS2 affects floral organ and leaf development. Single- and double-mutant analyses reveal that PFS2 activity represses AGAMOUS expression in young floral primordia. Also involved in regulation of response to low temperature.
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Genomic context

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Location:
chromosome: 2
Exon count:
4
Sequence:
Chromosome: 2; NC_003071.7 (224156..226234, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene O-fucosyltransferase family protein Neighboring gene phytanoyl-CoA dioxygenase (PhyH) family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene CLAVATA3/ESR-RELATED 16 Neighboring gene MLP-like protein 328

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The PRETTY FEW SEEDS2 gene encodes an Arabidopsis homeodomain protein that regulates ovule development. Park SO, et al. Development, 2005 Feb. PMID 15659481
  2. An Arabidopsis homeodomain transcription factor gene, HOS9, mediates cold tolerance through a CBF-independent pathway. Zhu J, et al. Proc Natl Acad Sci U S A, 2004 Jun 29. PMID 15205481, Free PMC Article
  3. The phenotype of Arabidopsis ovule mutants mimics the morphology of primitive seed plants. Park SO, et al. Proc Biol Sci, 2004 Feb 7. PMID 15058443, Free PMC Article
  4. Haploinsufficiency after successive loss of signaling reveals a role for ERECTA-family genes in Arabidopsis ovule development. Pillitteri LJ, et al. Development, 2007 Sep. PMID 17652352
  5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic interaction of the ER family and the WOX-family gene, PFS2, reveals their contribution to integument development through interrelated mechanisms.
    Title: Haploinsufficiency after successive loss of signaling reveals a role for ERECTA-family genes in Arabidopsis ovule development.
  2. PRETTY FEW SEEDS2 gene encodes a homeodomain transcription factor which affects either ovule patterning or differentiation [PFS2] [PRETTY FEW SEEDS2]
    Title: The PRETTY FEW SEEDS2 gene encodes an Arabidopsis homeodomain protein that regulates ovule development.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_126211.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo sac morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within floral organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within petal morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plant ovule morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of unidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold NAS
Non-traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in primary endosperm nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Homeodomain-like superfamily protein
NP_565263.1
  • PRETTY FEW SEEDS 2 (PFS2); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 9 processes; LOCATED IN: primary endosperm nucleus, nucleus; EXPRESSED IN: 12 plant structures; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057); BEST Arabidopsis thaliana protein match is: WUSCHEL related homeobox 1 (TAIR:AT3G18010.1); Has 564 Blast hits to 564 proteins in 49 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 4; Plants - 560; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    224156..226234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126211.2 → NP_565263.1  Homeodomain-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565263.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9ZVF5
    UniProtKB/TrEMBL
    A0A178VTV0, A0A384KZD3, A0MEH4, Q1PFB2
    Conserved Domains (1) summary
    pfam00046
    Location:61 → 115
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZVF5.2

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