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SLC25A32 solute carrier family 25 member 32 [ Homo sapiens (human) ]

Gene ID: 81034, updated on 20-Dec-2019

Summary

Official Symbol
SLC25A32provided by HGNC
Official Full Name
solute carrier family 25 member 32provided by HGNC
Primary source
HGNC:HGNC:29683
See related
Ensembl:ENSG00000164933 MIM:610815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MFT; MFTC; RREI
Summary
This gene encodes a member of the P(I/L)W subfamily of mitochondrial carrier family transport proteins. The encoded protein transports folate across the inner mitochondrial membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in appendix (RPKM 5.6), lymph node (RPKM 5.3) and 25 other tissues See more
Orthologs

Genomic context

See SLC25A32 in Genome Data Viewer
Location:
8q22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (103398638..103415335, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (104410866..104427563, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1011, pseudogene Neighboring gene collagen triple helix repeat containing 1 Neighboring gene uncharacterized LOC105375690 Neighboring gene DDB1 and CUL4 associated factor 13 Neighboring gene Sharpr-MPRA regulatory region 6081 Neighboring gene regulating synaptic membrane exocytosis 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23872

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FAD transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
folic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
folic acid transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
folic acid transmembrane transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
folic acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
FAD transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
folate import into mitochondrion IGI
Inferred from Genetic Interaction
more info
PubMed 
folic acid metabolic process TAS
Traceable Author Statement
more info
 
folic acid transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial folate transporter/carrier
Names
solute carrier family 25 (mitochondrial folate carrier), member 32

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047200.1 RefSeqGene

    Range
    5229..21698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030780.5NP_110407.2  mitochondrial folate transporter/carrier

    See identical proteins and their annotated locations for NP_110407.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AF283645, BC021893, DB087013
    Consensus CDS
    CCDS6300.1
    UniProtKB/Swiss-Prot
    Q9H2D1
    UniProtKB/TrEMBL
    A0A024R9D0
    Related
    ENSP00000297578.4, ENST00000297578.9
    Conserved Domains (1) summary
    cl28162
    Location:26307
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_102337.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF283645, BC021893, DB087013, DC331449
    Related
    ENST00000523256.6
  2. NR_102338.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF283645, AL046268, BC021893, DB087013
    Related
    ENST00000521645.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    103398638..103415335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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