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Senp3 SUMO/sentrin specific peptidase 3 [ Mus musculus (house mouse) ]

Gene ID: 80886, updated on 2-Nov-2024

Summary

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Official Symbol
Senp3provided by MGI
Official Full Name
SUMO/sentrin specific peptidase 3provided by MGI
Primary source
MGI:MGI:2158736
See related
Ensembl:ENSMUSG00000005204 AllianceGenome:MGI:2158736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Smt3ip; Smt3ip1
Summary
Enables cysteine-type deubiquitinase activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination and protein desumoylation. Located in nucleolus. Is expressed in cerebral cortex and heart. Orthologous to human SENP3 (SUMO specific peptidase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 28.8), CNS E18 (RPKM 23.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Senp3 in Genome Data Viewer
Location:
11 B3; 11 42.86 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69563936..69572910, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69673110..69682084, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene predicted gene, 25835 Neighboring gene STARR-positive B cell enhancer ABC_E8419 Neighboring gene predicted gene, 22988 Neighboring gene STARR-positive B cell enhancer ABC_E734 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13, opposite strand Neighboring gene tumor necrosis factor (ligand) superfamily, membrane-bound member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SENP3 in monocytes/macrophages up-regulates tissue factor and mediates lipopolysaccharide-induced acute lung injury by enhancing JNK phosphorylation. Chen X, et al. J Cell Mol Med, 2020 May. PMID 32237051, Free PMC Article
  2. Expression and Cell Distribution of SENP3 in Brain Tissue After Traumatic Brain Injury in Mice: A Pilot Study. Yu Z, et al. Cell Mol Neurobiol, 2015 Jul. PMID 25772139
  3. SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury. He S, et al. Innate Immun, 2023 Jan. PMID 37016838, Free PMC Article
  4. SENP3 protects H9C2 cells from apoptosis triggered by H/R via STAT3 pathway. Zhang Y, et al. Eur Rev Med Pharmacol Sci, 2018 May. PMID 29771430
  5. Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity. Hu G, et al. Cell Death Dis, 2022 Jul 22. PMID 35869062, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development.
    Title: SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development.
  2. SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1.
    Title: SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1.
  3. Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation.
    Title: Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation.
  4. SENP3 facilitates M1 macrophage polarization via the HIF-1alpha/PKM2 axis in lipopolysaccharide-induced acute lung injury.
    Title: SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury.
  5. Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage.
    Title: Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage.
  6. Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity.
    Title: Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity.
  7. SENP3 loss promotes M2 macrophage polarization and breast cancer progression.
    Title: SENP3 loss promotes M2 macrophage polarization and breast cancer progression.
  8. Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of beta-catenin and regulation of its stability.
    Title: Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of β-catenin and regulation of its stability.
  9. SENP3 in monocytes/macrophages up-regulates tissue factor and mediates lipopolysaccharide-induced acute lung injury by enhancing JNK phosphorylation.
    Title: SENP3 in monocytes/macrophages up-regulates tissue factor and mediates lipopolysaccharide-induced acute lung injury by enhancing JNK phosphorylation.
  10. A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3.
    Title: A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deSUMOylase activity ISO
Inferred from Sequence Orthology
more info
  
enables deSUMOylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein desumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein desumoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sentrin-specific protease 3
Names
SUMO-1-specific protease 3
SUMO/sentrin specific protease 3
sentrin/SUMO-specific protease SENP3
smt3-specific isopeptidase 1
NP_001157043.1
NP_109627.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163571.1 → NP_001157043.1  sentrin-specific protease 3

    See identical proteins and their annotated locations for NP_001157043.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL603707
    Consensus CDS
    CCDS24905.1
    UniProtKB/Swiss-Prot
    Q5F2A5, Q8BRD5, Q8C2H5, Q9EP97
    Related
    ENSMUSP00000066581.2, ENSMUST00000066760.8
    Conserved Domains (1) summary
    pfam02902
    Location:394 → 566
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. NM_030702.4 → NP_109627.3  sentrin-specific protease 3

    See identical proteins and their annotated locations for NP_109627.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK045071, AY008764, BY134888
    Consensus CDS
    CCDS24905.1
    UniProtKB/Swiss-Prot
    Q5F2A5, Q8BRD5, Q8C2H5, Q9EP97
    Related
    ENSMUSP00000005336.3, ENSMUST00000005336.9
    Conserved Domains (1) summary
    pfam02902
    Location:394 → 566
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69563936..69572910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EP97.1 GenPept UniProtKB/Swiss-Prot:Q9EP97

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