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Senp3 SUMO/sentrin specific peptidase 3 [ Mus musculus (house mouse) ]

Gene ID: 80886, updated on 4-Dec-2022

Summary

Official Symbol
Senp3provided by MGI
Official Full Name
SUMO/sentrin specific peptidase 3provided by MGI
Primary source
MGI:MGI:2158736
See related
Ensembl:ENSMUSG00000005204 AllianceGenome:MGI:2158736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Smt3ip; Smt3ip1
Summary
Enables thiol-dependent deubiquitinase. Acts upstream of or within protein metabolic process. Located in nucleolus. Is expressed in heart. Orthologous to human SENP3 (SUMO specific peptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 28.8), CNS E18 (RPKM 23.8) and 28 other tissues See more
Orthologs
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Genomic context

See Senp3 in Genome Data Viewer
Location:
11; 11 B3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69563936..69572910, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69673110..69682084, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene predicted gene, 25835 Neighboring gene predicted gene, 22988 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13, opposite strand Neighboring gene tumor necrosis factor (ligand) superfamily, membrane-bound member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deSUMOylase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein desumoylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sentrin-specific protease 3
Names
SUMO-1-specific protease 3
SUMO/sentrin specific protease 3
sentrin/SUMO-specific protease SENP3
smt3-specific isopeptidase 1
NP_001157043.1
NP_109627.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163571.1NP_001157043.1  sentrin-specific protease 3

    See identical proteins and their annotated locations for NP_001157043.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL603707
    Consensus CDS
    CCDS24905.1
    UniProtKB/Swiss-Prot
    Q8C2H5, Q9EP97
    Related
    ENSMUSP00000066581.2, ENSMUST00000066760.8
    Conserved Domains (1) summary
    pfam02902
    Location:394566
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  2. NM_030702.4NP_109627.3  sentrin-specific protease 3

    See identical proteins and their annotated locations for NP_109627.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK045071, AY008764, BY134888
    Consensus CDS
    CCDS24905.1
    UniProtKB/Swiss-Prot
    Q8C2H5, Q9EP97
    Related
    ENSMUSP00000005336.3, ENSMUST00000005336.9
    Conserved Domains (1) summary
    pfam02902
    Location:394566
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69563936..69572910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)