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GRIP2 glutamate receptor interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 80852, updated on 13-May-2022

Summary

Official Symbol
GRIP2provided by HGNC
Official Full Name
glutamate receptor interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:23841
See related
Ensembl:ENSG00000144596 AllianceGenome:HGNC:23841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein C-terminus binding activity. Predicted to be involved in several processes, including neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of AMPA glutamate receptor clustering; and positive regulation of excitatory postsynaptic potential. Predicted to act upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Predicted to be located in cytoplasm; dendritic shaft; and neuron spine. Predicted to be active in glutamatergic synapse and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart (RPKM 7.1), spleen (RPKM 5.7) and 21 other tissues See more
Orthologs
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Genomic context

See GRIP2 in Genome Data Viewer
Location:
3p25.1
Exon count:
30
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (14489107..14603017, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (14491513..14542748, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (14530615..14581849, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376959 Neighboring gene RNA, 5S ribosomal pseudogene 124 Neighboring gene solute carrier family 6 member 6 Neighboring gene Sharpr-MPRA regulatory region 14405 Neighboring gene Sharpr-MPRA regulatory region 227/3570 Neighboring gene RNA, U6 small nuclear 905, pseudogene Neighboring gene RHBDF1 pseudogene 1 Neighboring gene uncharacterized LOC105376960 Neighboring gene uncharacterized LOC124909347 Neighboring gene uncharacterized LOC124906215 Neighboring gene coiled-coil domain containing 174

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor complex adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in artery smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport in synapse IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutamate receptor-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080423.4NP_001073892.3  glutamate receptor-interacting protein 2

    See identical proteins and their annotated locations for NP_001073892.3

    Status: VALIDATED

    Source sequence(s)
    AB051506, AC090952, AK024507, AK095762
    Consensus CDS
    CCDS46766.2
    UniProtKB/Swiss-Prot
    Q9C0E4
    UniProtKB/TrEMBL
    A0A087WU38
    Related
    ENSP00000478352.1, ENST00000621039.5
    Conserved Domains (1) summary
    cd00992
    Location:655735
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    14489107..14603017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449036.1XP_047304992.1  glutamate receptor-interacting protein 2 isoform X4

  2. XM_011534142.4XP_011532444.1  glutamate receptor-interacting protein 2 isoform X2

    Conserved Domains (1) summary
    cd00992
    Location:660740
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_011534143.4XP_011532445.1  glutamate receptor-interacting protein 2 isoform X3

    Conserved Domains (1) summary
    cd00992
    Location:620700
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_011534141.4XP_011532443.1  glutamate receptor-interacting protein 2 isoform X1

    Related
    ENSP00000490949.1, ENST00000637182.1
    Conserved Domains (1) summary
    cd00992
    Location:662742
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_011534146.4XP_011532448.1  glutamate receptor-interacting protein 2 isoform X7

    Conserved Domains (1) summary
    cd00992
    Location:408488
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_011534145.4XP_011532447.1  glutamate receptor-interacting protein 2 isoform X6

    Conserved Domains (1) summary
    cd00992
    Location:434514
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. XM_047449037.1XP_047304993.1  glutamate receptor-interacting protein 2 isoform X5

  8. XM_047449038.1XP_047304994.1  glutamate receptor-interacting protein 2 isoform X8

  9. XM_047449040.1XP_047304996.1  glutamate receptor-interacting protein 2 isoform X9

RNA

  1. XR_007095752.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    14491513..14542748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)