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Grip2 glutamate receptor interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 243547, updated on 27-Nov-2024

Summary

Official Symbol
Grip2provided by MGI
Official Full Name
glutamate receptor interacting protein 2provided by MGI
Primary source
MGI:MGI:2681173
See related
Ensembl:ENSMUSG00000030098 AllianceGenome:MGI:2681173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable glutamate receptor binding activity. Involved in neurotransmitter receptor transport, endosome to postsynaptic membrane and vesicle-mediated transport in synapse. Acts upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Is active in glutamatergic synapse. Is expressed in diencephalon lateral wall mantle layer; olfactory cortex mantle layer; and tongue. Orthologous to human GRIP2 (glutamate receptor interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 10.3), CNS E18 (RPKM 10.0) and 18 other tissues See more
Orthologs
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Genomic context

See Grip2 in Genome Data Viewer
Location:
6 D1; 6 40.8 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (91738433..91820884, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (91761452..91843954, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:91629122-91629420 Neighboring gene predicted gene, 40387 Neighboring gene predicted gene, 30628 Neighboring gene STARR-seq mESC enhancer starr_16652 Neighboring gene solute carrier family 6 (neurotransmitter transporter, taurine), member 6 Neighboring gene STARR-seq mESC enhancer starr_16656 Neighboring gene STARR-seq mESC enhancer starr_16660 Neighboring gene coiled-coil domain containing 174 Neighboring gene STARR-positive B cell enhancer ABC_E6456 Neighboring gene RIKEN cDNA 4930590J08 gene Neighboring gene predicted gene, 53299

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within artery smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of AMPA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport in synapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport in synapse IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in vesicle-mediated transport in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuron spine ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159507.2NP_001152979.1  glutamate receptor-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001152979.1

    Status: VALIDATED

    Source sequence(s)
    AC162914
    Consensus CDS
    CCDS51852.1
    UniProtKB/TrEMBL
    E0CXS4, G3XA20
    Related
    ENSMUSP00000124709.2, ENSMUST00000162300.8
    Conserved Domains (1) summary
    cd00992
    Location:657737
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001411663.1NP_001398592.1  glutamate receptor-interacting protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162914, AC168852
  3. NM_001411664.1NP_001398593.1  glutamate receptor-interacting protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC162914

RNA

  1. NR_177446.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC162914
  2. NR_177447.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC162914
    Related
    ENSMUST00000162293.8
  3. NR_177448.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC162914

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    91738433..91820884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506103.4XP_006506166.1  glutamate receptor-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    E0CXS4
    Conserved Domains (1) summary
    cd00992
    Location:664744
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. XR_003956198.1 RNA Sequence

  2. XR_004942951.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033353.1: Suppressed sequence

    Description
    NM_001033353.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.