Format

Send to:

Choose Destination

PTP4A2 protein tyrosine phosphatase 4A2 [ Homo sapiens (human) ]

Gene ID: 8073, updated on 7-Jun-2020

Summary

Official Symbol
PTP4A2provided by HGNC
Official Full Name
protein tyrosine phosphatase 4A2provided by HGNC
Primary source
HGNC:HGNC:9635
See related
Ensembl:ENSG00000184007 MIM:601584
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b
Summary
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Expression
Ubiquitous expression in thyroid (RPKM 58.0), bone marrow (RPKM 56.7) and 25 other tissues See more
Orthologs

Genomic context

See PTP4A2 in Genome Data Viewer
Location:
1p35.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (31906421..31938368, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32372022..32403988, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor B2 Neighboring gene microRNA 4254 Neighboring gene SPOC domain containing 1 Neighboring gene PTP4A2-KHDRBS1 intergenic CAGE-defined high expression enhancer Neighboring gene KH RNA binding domain containing, signal transduction associated 1 Neighboring gene VISTA enhancer hs645

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
prenylated protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein tyrosine phosphatase type IVA 2
Names
PTP(CAAXII)
phosphatase of regenerating liver 2
protein tyrosine phosphatase IVA
protein tyrosine phosphatase IVA2
protein tyrosine phosphatase type IVA, member 2
protein-tyrosine phosphatase of regenerating liver 2
NP_001182029.1
NP_001182030.1
NP_001356787.1
NP_001356788.1
NP_001356789.1
NP_536316.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195100.2NP_001182029.1  protein tyrosine phosphatase type IVA 2 isoform 3

    See identical proteins and their annotated locations for NP_001182029.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AL136115, BC018662, BC070181
    Consensus CDS
    CCDS59193.1
    UniProtKB/Swiss-Prot
    Q12974
    Related
    ENSP00000473490.1, ENST00000602683.5
    Conserved Domains (1) summary
    cl21483
    Location:8132
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001195101.2NP_001182030.1  protein tyrosine phosphatase type IVA 2 isoform 4

    See identical proteins and their annotated locations for NP_001182030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1. Variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AL136115, BC018662, BC070181
    Consensus CDS
    CCDS53292.1
    UniProtKB/Swiss-Prot
    Q12974
    Conserved Domains (1) summary
    cl28904
    Location:1124
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  3. NM_001369858.1NP_001356787.1  protein tyrosine phosphatase type IVA 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL136115, BC070181
    Related
    ENSP00000409260.2, ENST00000457805.6
    Conserved Domains (1) summary
    cl28904
    Location:1124
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  4. NM_001369859.1NP_001356788.1  protein tyrosine phosphatase type IVA 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL136115, BC070181, BI549454, DB503104
    Related
    ENSP00000497092.1, ENST00000649841.1
    Conserved Domains (1) summary
    cd18536
    Location:1155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2
  5. NM_001369860.1NP_001356789.1  protein tyrosine phosphatase type IVA 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL136115, BC070181, DB503104
    Related
    ENSP00000473259.1, ENST00000602725.5
    Conserved Domains (1) summary
    cd18536
    Location:1155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2
  6. NM_080391.4NP_536316.1  protein tyrosine phosphatase type IVA 2 isoform 1

    See identical proteins and their annotated locations for NP_536316.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 6 and 7 encode the same isoform.
    Source sequence(s)
    AL136115, BC018662, BC070182, BM996809
    Consensus CDS
    CCDS348.1
    UniProtKB/Swiss-Prot
    Q12974
    Related
    ENSP00000493688.1, ENST00000647444.2
    Conserved Domains (1) summary
    cd18536
    Location:1155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    31906421..31938368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002957649.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003479.2: Suppressed sequence

    Description
    NM_003479.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
  2. NM_080392.2: Suppressed sequence

    Description
    NM_080392.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center