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Ptp4a2 protein tyrosine phosphatase 4a2 [ Mus musculus (house mouse) ]

Gene ID: 19244, updated on 5-Jan-2023

Summary

Official Symbol
Ptp4a2provided by MGI
Official Full Name
protein tyrosine phosphatase 4a2provided by MGI
Primary source
MGI:MGI:1277117
See related
Ensembl:ENSMUSG00000028788 AllianceGenome:MGI:1277117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prl-2
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in endosome and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system. Orthologous to human PTP4A2 (protein tyrosine phosphatase 4A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 35.0), CNS E11.5 (RPKM 30.5) and 28 other tissues See more
Orthologs
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Genomic context

See Ptp4a2 in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129714262..129743796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129811165..129850003)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene KH domain containing, RNA binding, signal transduction associated 1 Neighboring gene predicted gene 12967 Neighboring gene RIKEN cDNA 1700108I11 gene Neighboring gene predicted gene, 23845

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102154, MGC103400

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein tyrosine phosphatase type IVA 2
Names
protein-tyrosine phosphatase of regenerating liver 2
NP_001158217.1
NP_033000.1
XP_006502926.1
XP_017175534.1
XP_036019730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164745.1NP_001158217.1  protein tyrosine phosphatase type IVA 2

    See identical proteins and their annotated locations for NP_001158217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BB675559, BC086794, BC087551, BY791716
    Consensus CDS
    CCDS18704.1
    UniProtKB/Swiss-Prot
    O70274, Q3U1K7
    UniProtKB/TrEMBL
    A0A6P5PER9, A0A8C6G6J4
    Related
    ENSMUSP00000125901.2, ENSMUST00000165853.2
    Conserved Domains (1) summary
    cd18536
    Location:1155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2
  2. NM_008974.4NP_033000.1  protein tyrosine phosphatase type IVA 2

    See identical proteins and their annotated locations for NP_033000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BB675559, BC086794, BC087551, BY110331
    Consensus CDS
    CCDS18704.1
    UniProtKB/Swiss-Prot
    O70274, Q3U1K7
    UniProtKB/TrEMBL
    A0A6P5PER9, A0A8C6G6J4
    Related
    ENSMUSP00000030578.8, ENSMUST00000030578.14
    Conserved Domains (1) summary
    cd18536
    Location:1155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129714262..129743796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502863.4XP_006502926.1  protein tyrosine phosphatase type IVA 2 isoform X2

    See identical proteins and their annotated locations for XP_006502926.1

    Conserved Domains (1) summary
    cl28904
    Location:1130
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. XM_036163837.1XP_036019730.1  protein tyrosine phosphatase type IVA 2 isoform X2

    Conserved Domains (1) summary
    cl28904
    Location:1130
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  3. XM_017320045.3XP_017175534.1  protein tyrosine phosphatase type IVA 2 isoform X1

    UniProtKB/Swiss-Prot
    O70274, Q3U1K7
    UniProtKB/TrEMBL
    A0A6P5PER9, A0A8C6G6J4
    Conserved Domains (1) summary
    cd18536
    Location:1155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2