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AKNA AT-hook transcription factor [ Homo sapiens (human) ]

Gene ID: 80709, updated on 24-Dec-2019

Summary

Official Symbol
AKNAprovided by HGNC
Official Full Name
AT-hook transcription factorprovided by HGNC
Primary source
HGNC:HGNC:24108
See related
Ensembl:ENSG00000106948 MIM:605729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in spleen (RPKM 28.7), lymph node (RPKM 23.1) and 20 other tissues See more
Orthologs

Genomic context

See AKNA in Genome Data Viewer
Location:
9q32
Exon count:
28
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (114334149..114398498, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117096429..117160783, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene orosomucoid 1 Neighboring gene orosomucoid 2 Neighboring gene whirlin Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene uncharacterized LOC105376228

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31001, FLJ33184, KIAA1968

Gene Ontology Provided by GOA

Process Evidence Code Pubs
delamination ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
neuroblast delamination ISS
Inferred from Sequence or Structural Similarity
more info
 
neuroblast division in subventricular zone ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
centriole ISS
Inferred from Sequence or Structural Similarity
more info
 
centrosome IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
microtubule organization protein AKNA
Names
AKNA transcript F2
AT-hook transcription factor AKNA
AT-hook-containing transcription factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317950.2NP_001304879.1  microtubule organization protein AKNA isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK131082, AL356796, AL833220, AY703040
    Consensus CDS
    CCDS6805.1
    UniProtKB/Swiss-Prot
    Q7Z591
    UniProtKB/TrEMBL
    Q64FY1
    Related
    ENSP00000363201.3, ENST00000374088.7
    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  2. NM_001317952.1NP_001304881.1  microtubule organization protein AKNA isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start site, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL833220, AY703040
    UniProtKB/Swiss-Prot
    Q7Z591
    UniProtKB/TrEMBL
    Q64FY1
    Related
    ENSP00000363188.5, ENST00000374075.9
    Conserved Domains (1) summary
    pfam12443
    Location:479577
    AKNA; AT-hook-containing transcription factor
  3. NM_030767.5NP_110394.3  microtubule organization protein AKNA isoform 1

    See identical proteins and their annotated locations for NP_110394.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AL833220, AY703040, BC055285
    Consensus CDS
    CCDS6805.1
    UniProtKB/Swiss-Prot
    Q7Z591
    UniProtKB/TrEMBL
    Q64FY1
    Related
    ENSP00000303769.4, ENST00000307564.8
    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    114334149..114398498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252244.2XP_005252301.1  microtubule organization protein AKNA isoform X1

    See identical proteins and their annotated locations for XP_005252301.1

    UniProtKB/Swiss-Prot
    Q7Z591
    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  2. XM_017015172.2XP_016870661.1  microtubule organization protein AKNA isoform X3

    UniProtKB/Swiss-Prot
    Q7Z591
    Conserved Domains (1) summary
    pfam12443
    Location:479577
    AKNA; AT-hook-containing transcription factor
  3. XM_006717294.1XP_006717357.1  microtubule organization protein AKNA isoform X1

    See identical proteins and their annotated locations for XP_006717357.1

    UniProtKB/Swiss-Prot
    Q7Z591
    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  4. XM_011519065.2XP_011517367.2  microtubule organization protein AKNA isoform X3

    UniProtKB/Swiss-Prot
    Q7Z591
    Conserved Domains (1) summary
    pfam12443
    Location:479577
    AKNA; AT-hook-containing transcription factor
  5. XM_005252245.1XP_005252302.1  microtubule organization protein AKNA isoform X1

    See identical proteins and their annotated locations for XP_005252302.1

    UniProtKB/Swiss-Prot
    Q7Z591
    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  6. XM_005252248.3XP_005252305.1  microtubule organization protein AKNA isoform X2

    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  7. XM_011519063.2XP_011517365.1  microtubule organization protein AKNA isoform X3

    See identical proteins and their annotated locations for XP_011517365.1

    UniProtKB/Swiss-Prot
    Q7Z591
    Conserved Domains (1) summary
    pfam12443
    Location:479577
    AKNA; AT-hook-containing transcription factor
  8. XM_005252247.5XP_005252304.1  microtubule organization protein AKNA isoform X1

    See identical proteins and their annotated locations for XP_005252304.1

    UniProtKB/Swiss-Prot
    Q7Z591
    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  9. XM_011519064.3XP_011517366.1  microtubule organization protein AKNA isoform X4

    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  10. XM_011519066.3XP_011517368.1  microtubule organization protein AKNA isoform X5

    Related
    ENSP00000309222.3, ENST00000312033.3
    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor

RNA

  1. XR_929844.3 RNA Sequence

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