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AKNA AT-hook transcription factor [ Homo sapiens (human) ]

Gene ID: 80709, updated on 5-Aug-2022

Summary

Official Symbol
AKNAprovided by HGNC
Official Full Name
AT-hook transcription factorprovided by HGNC
Primary source
HGNC:HGNC:24108
See related
Ensembl:ENSG00000106948 MIM:605729; AllianceGenome:HGNC:24108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in centrosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 28.7), lymph node (RPKM 23.1) and 20 other tissues See more
Orthologs
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Genomic context

See AKNA in Genome Data Viewer
Location:
9q32
Exon count:
31
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (114330504..114398472, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (126526573..126586836, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117096436..117156685, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376224 Neighboring gene Sharpr-MPRA regulatory region 10745 Neighboring gene orosomucoid 1 Neighboring gene orosomucoid 2 Neighboring gene uncharacterized LOC124902253 Neighboring gene whirlin Neighboring gene uncharacterized LOC124902254 Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 12257

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31001, FLJ33184, KIAA1968

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in delamination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial to mesenchymal transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuroblast delamination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuroblast delamination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuroblast division in subventricular zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuroblast division in subventricular zone ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
microtubule organization protein AKNA
Names
AKNA transcript F2
AT-hook transcription factor AKNA
AT-hook-containing transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317950.2NP_001304879.1  microtubule organization protein AKNA isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK131082, AL356796, AL833220, AY703040
    Consensus CDS
    CCDS6805.1
    UniProtKB/Swiss-Prot
    Q7Z591, Q9H7P7
    UniProtKB/TrEMBL
    Q64FY1
    Related
    ENSP00000363201.3, ENST00000374088.8
    Conserved Domains (2) summary
    PHA03247
    Location:10931383
    PHA03247; large tegument protein UL36; Provisional
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  2. NM_001317952.1NP_001304881.1  microtubule organization protein AKNA isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start site, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL833220, AY703040
    UniProtKB/Swiss-Prot
    Q7Z591
    UniProtKB/TrEMBL
    Q64FY1
    Related
    ENSP00000363188.5, ENST00000374075.9
    Conserved Domains (2) summary
    PHA03247
    Location:9741264
    PHA03247; large tegument protein UL36; Provisional
    pfam12443
    Location:479577
    AKNA; AT-hook-containing transcription factor
  3. NM_030767.5NP_110394.3  microtubule organization protein AKNA isoform 1

    See identical proteins and their annotated locations for NP_110394.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AL833220, AY703040, BC055285
    Consensus CDS
    CCDS6805.1
    UniProtKB/Swiss-Prot
    Q7Z591, Q9H7P7
    UniProtKB/TrEMBL
    Q64FY1
    Related
    ENSP00000303769.4, ENST00000307564.8
    Conserved Domains (2) summary
    PHA03247
    Location:10931383
    PHA03247; large tegument protein UL36; Provisional
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    114330504..114398472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717294.2XP_006717357.1  microtubule organization protein AKNA isoform X1

    See identical proteins and their annotated locations for XP_006717357.1

    UniProtKB/Swiss-Prot
    Q7Z591, Q9H7P7
    Conserved Domains (2) summary
    PHA03247
    Location:10931383
    PHA03247; large tegument protein UL36; Provisional
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  2. XM_011519065.3XP_011517367.2  microtubule organization protein AKNA isoform X3

    UniProtKB/Swiss-Prot
    Q7Z591
    Conserved Domains (2) summary
    PHA03247
    Location:9741264
    PHA03247; large tegument protein UL36; Provisional
    pfam12443
    Location:479577
    AKNA; AT-hook-containing transcription factor
  3. XM_005252245.2XP_005252302.1  microtubule organization protein AKNA isoform X1

    See identical proteins and their annotated locations for XP_005252302.1

    UniProtKB/Swiss-Prot
    Q7Z591, Q9H7P7
    Conserved Domains (2) summary
    PHA03247
    Location:10931383
    PHA03247; large tegument protein UL36; Provisional
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  4. XM_005252244.3XP_005252301.1  microtubule organization protein AKNA isoform X1

    See identical proteins and their annotated locations for XP_005252301.1

    UniProtKB/Swiss-Prot
    Q7Z591, Q9H7P7
    Conserved Domains (2) summary
    PHA03247
    Location:10931383
    PHA03247; large tegument protein UL36; Provisional
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  5. XM_047423922.1XP_047279878.1  microtubule organization protein AKNA isoform X1

    UniProtKB/Swiss-Prot
    Q9H7P7
  6. XM_047423921.1XP_047279877.1  microtubule organization protein AKNA isoform X1

    UniProtKB/Swiss-Prot
    Q9H7P7
  7. XM_011519063.3XP_011517365.1  microtubule organization protein AKNA isoform X3

    See identical proteins and their annotated locations for XP_011517365.1

    UniProtKB/Swiss-Prot
    Q7Z591
    Conserved Domains (2) summary
    PHA03247
    Location:9741264
    PHA03247; large tegument protein UL36; Provisional
    pfam12443
    Location:479577
    AKNA; AT-hook-containing transcription factor
  8. XM_047423924.1XP_047279880.1  microtubule organization protein AKNA isoform X5

  9. XM_005252248.4XP_005252305.1  microtubule organization protein AKNA isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:11001351
    PHA03247; large tegument protein UL36; Provisional
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  10. XM_005252247.6XP_005252304.1  microtubule organization protein AKNA isoform X1

    See identical proteins and their annotated locations for XP_005252304.1

    UniProtKB/Swiss-Prot
    Q7Z591, Q9H7P7
    Conserved Domains (2) summary
    PHA03247
    Location:10931383
    PHA03247; large tegument protein UL36; Provisional
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  11. XM_047423923.1XP_047279879.1  microtubule organization protein AKNA isoform X4

  12. XM_047423925.1XP_047279881.1  microtubule organization protein AKNA isoform X6

  13. XM_011519064.3XP_011517366.1  microtubule organization protein AKNA isoform X7

    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor
  14. XM_047423926.1XP_047279882.1  microtubule organization protein AKNA isoform X8

  15. XM_011519066.4XP_011517368.1  microtubule organization protein AKNA isoform X9

    Related
    ENSP00000309222.3, ENST00000312033.3
    Conserved Domains (1) summary
    pfam12443
    Location:598696
    AKNA; AT-hook-containing transcription factor

RNA

  1. XR_929844.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    126526573..126586836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)