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WDR61 WD repeat domain 61 [ Homo sapiens (human) ]

Gene ID: 80349, updated on 5-Jul-2020

Summary

Official Symbol
WDR61provided by HGNC
Official Full Name
WD repeat domain 61provided by HGNC
Primary source
HGNC:HGNC:30300
See related
Ensembl:ENSG00000140395 MIM:609540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SKI8; REC14
Summary
WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 14.1), testis (RPKM 13.6) and 25 other tissues See more
Orthologs

Genomic context

See WDR61 in Genome Data Viewer
Location:
15q25.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (78283233..78299703, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78575575..78591977, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370911 Neighboring gene uncharacterized LOC105370910 Neighboring gene DnaJ heat shock protein family (Hsp40) member A4 Neighboring gene cellular retinoic acid binding protein 1 Neighboring gene RWD domain containing 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 IN is identified to have a physical interaction with WD repeat domain 61 (WDR61) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Cdc73/Paf1 complex IDA
Inferred from Direct Assay
more info
PubMed 
Ski complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcriptionally active chromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 61
Names
SKI8 homolog
meiotic recombination REC14 protein homolog
recombination protein REC14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303247.2NP_001290176.1  WD repeat-containing protein 61 isoform a

    See identical proteins and their annotated locations for NP_001290176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK024754, BI916225, DB451240
    Consensus CDS
    CCDS10300.1
    UniProtKB/Swiss-Prot
    Q9GZS3
    Related
    ENSP00000453902.1, ENST00000560569.5
    Conserved Domains (2) summary
    cd00200
    Location:13302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:110146
    7WD40; WD40 repeat [structural motif]
  2. NM_001303248.2NP_001290177.1  WD repeat-containing protein 61 isoform b

    See identical proteins and their annotated locations for NP_001290177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame pair of exons in the middle of the transcript compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK024754, BI916225, BU528743
    Consensus CDS
    CCDS76785.1
    UniProtKB/Swiss-Prot
    Q9GZS3
    UniProtKB/TrEMBL
    H0YL19
    Related
    ENSP00000453024.1, ENST00000558459.5
    Conserved Domains (2) summary
    cd00200
    Location:17209
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1753
    7WD40; WD40 repeat [structural motif]
  3. NM_025234.3NP_079510.1  WD repeat-containing protein 61 isoform a

    See identical proteins and their annotated locations for NP_079510.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK024754, BI916225
    Consensus CDS
    CCDS10300.1
    UniProtKB/Swiss-Prot
    Q9GZS3
    Related
    ENSP00000267973.2, ENST00000267973.7
    Conserved Domains (2) summary
    cd00200
    Location:13302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:110146
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    78283233..78299703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522094.2XP_011520396.1  WD repeat-containing protein 61 isoform X1

    See identical proteins and their annotated locations for XP_011520396.1

    UniProtKB/Swiss-Prot
    Q9GZS3
    Related
    ENSP00000453801.1, ENST00000558311.5
    Conserved Domains (2) summary
    cd00200
    Location:13302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:110146
    7WD40; WD40 repeat [structural motif]
  2. XM_017022637.2XP_016878126.1  WD repeat-containing protein 61 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:13259
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:6249
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1962
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_931918.2 RNA Sequence

  2. XR_001751403.2 RNA Sequence

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