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GRPEL1 GrpE like 1, mitochondrial [ Homo sapiens (human) ]

Gene ID: 80273, updated on 8-Aug-2021

Summary

Official Symbol
GRPEL1provided by HGNC
Official Full Name
GrpE like 1, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:19696
See related
Ensembl:ENSG00000109519 MIM:606173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GrpE; HMGE; mt-GrpE#1
Expression
Ubiquitous expression in adrenal (RPKM 26.2), kidney (RPKM 13.9) and 25 other tissues See more
Orthologs
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Genomic context

See GRPEL1 in Genome Data Viewer
Location:
4p16.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (7058895..7068064, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (7060622..7069791, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100129931 Neighboring gene coiled-coil domain containing 96 Neighboring gene transcriptional adaptor 2B Neighboring gene uncharacterized LOC105374368 Neighboring gene uncharacterized LOC105374370 Neighboring gene long intergenic non-protein coding RNA 2447 Neighboring gene RN7SK pseudogene 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25609

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of PAM complex, Tim23 associated import motor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
grpE protein homolog 1, mitochondrial
Names
GrpE-like protein cochaperone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025196.4NP_079472.1  grpE protein homolog 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079472.1

    Status: VALIDATED

    Source sequence(s)
    AC097382, AF070525, BC024242
    Consensus CDS
    CCDS3396.1
    UniProtKB/Swiss-Prot
    Q9HAV7
    Related
    ENSP00000264954.4, ENST00000264954.5
    Conserved Domains (1) summary
    cd00446
    Location:72213
    GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    7058895..7068064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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