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Grpel1 GrpE-like 1, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 17713, updated on 1-Mar-2024

Summary

Official Symbol
Grpel1provided by MGI
Official Full Name
GrpE-like 1, mitochondrialprovided by MGI
Primary source
MGI:MGI:1334417
See related
Ensembl:ENSMUSG00000029198 AllianceGenome:MGI:1334417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mt-GrpE#1; mt-Grpel1
Summary
Predicted to enable several functions, including ATPase binding activity; adenyl-nucleotide exchange factor activity; and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; bone; midbrain ventricular layer; and vibrissa. Orthologous to human GRPEL1 (GrpE like 1, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 21.7), heart adult (RPKM 20.9) and 28 other tissues See more
Orthologs
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Genomic context

See Grpel1 in Genome Data Viewer
Location:
5 B3; 5 19.14 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (36622529..36631421)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36465185..36474077)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sortilin-related VPS10 domain containing receptor 2 Neighboring gene microRNA 7689 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36701008-36701161 Neighboring gene STARR-positive B cell enhancer mm9_chr5:36715900-36716201 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36720744-36720945 Neighboring gene RIKEN cDNA 2210406O10 gene Neighboring gene STARR-positive B cell enhancer ABC_E65 Neighboring gene STARR-positive B cell enhancer ABC_E3572 Neighboring gene transcriptional adaptor 2B Neighboring gene TBC1 domain family, member 14 Neighboring gene coiled-coil domain containing 96 Neighboring gene predicted gene, 32528

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC8152

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of PAM complex, Tim23 associated import motor IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
grpE protein homolog 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024478.2NP_077798.1  grpE protein homolog 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_077798.1

    Status: PROVISIONAL

    Source sequence(s)
    AK048732
    Consensus CDS
    CCDS19238.1
    UniProtKB/Swiss-Prot
    Q3TSZ3, Q99LP6
    UniProtKB/TrEMBL
    Q3UTB8
    Related
    ENSMUSP00000031099.4, ENSMUST00000031099.4
    Conserved Domains (1) summary
    cd00446
    Location:72213
    GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    36622529..36631421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)