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STAM signal transducing adaptor molecule [ Homo sapiens (human) ]

Gene ID: 8027, updated on 7-Jun-2020

Summary

Official Symbol
STAMprovided by HGNC
Official Full Name
signal transducing adaptor moleculeprovided by HGNC
Primary source
HGNC:HGNC:11357
See related
Ensembl:ENSG00000136738 MIM:601899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STAM1; STAM-1
Summary
This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See STAM in Genome Data Viewer
Location:
10p12.33
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (17644150..17716824)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17686124..17758823)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene STAM antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC107984212 Neighboring gene transmembrane protein 236 Neighboring gene mannose receptor C-type 1 Neighboring gene microRNA 511

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686J2352

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
ESCRT-0 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ESCRT-0 complex IDA
Inferred from Direct Assay
more info
PubMed 
ESCRT-0 complex TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
signal transducing adapter molecule 1
Names
HSE1 homolog
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324282.2NP_001311211.1  signal transducing adapter molecule 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC069542
  2. NM_001324283.2NP_001311212.1  signal transducing adapter molecule 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AC069542
    Conserved Domains (3) summary
    cd11964
    Location:163217
    SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
    pfam03127
    Location:256327
    GAT; GAT domain
    cl02544
    Location:192
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  3. NM_001324284.2NP_001311213.1  signal transducing adapter molecule 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
    Source sequence(s)
    AC069542
    Conserved Domains (3) summary
    cd11964
    Location:163217
    SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
    pfam03127
    Location:256327
    GAT; GAT domain
    cl02544
    Location:192
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  4. NM_001324285.2NP_001311214.1  signal transducing adapter molecule 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
    Source sequence(s)
    AC069542
    Conserved Domains (3) summary
    cd11964
    Location:163217
    SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
    pfam03127
    Location:256327
    GAT; GAT domain
    cl02544
    Location:192
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  5. NM_001324286.2NP_001311215.1  signal transducing adapter molecule 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC069542
  6. NM_001324287.2NP_001311216.1  signal transducing adapter molecule 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC069542
    UniProtKB/TrEMBL
    B4DZT2
    Conserved Domains (3) summary
    cd11964
    Location:102156
    SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
    pfam03127
    Location:195266
    GAT; GAT domain
    cl02544
    Location:131
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  7. NM_001324288.2NP_001311217.1  signal transducing adapter molecule 1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) and variant 9 both encode isoform f.
    Source sequence(s)
    AC069542
  8. NM_001324289.2NP_001311218.1  signal transducing adapter molecule 1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) and variant 8 both encode isoform f.
    Source sequence(s)
    AC069542
  9. NM_003473.4NP_003464.1  signal transducing adapter molecule 1 isoform a

    See identical proteins and their annotated locations for NP_003464.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC069542, AU118708, U43899
    Consensus CDS
    CCDS7122.1
    UniProtKB/Swiss-Prot
    Q92783
    Related
    ENSP00000366746.3, ENST00000377524.8
    Conserved Domains (3) summary
    cd11964
    Location:213267
    SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
    cd03568
    Location:9142
    VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
    pfam03127
    Location:306377
    GAT; GAT domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    17644150..17716824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519695.3XP_011517997.1  signal transducing adapter molecule 1 isoform X1

    Conserved Domains (3) summary
    cd11964
    Location:213267
    SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
    cd03568
    Location:9142
    VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
    pfam03127
    Location:306377
    GAT; GAT domain
  2. XM_017016685.2XP_016872174.1  signal transducing adapter molecule 1 isoform X2

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