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Stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [ Mus musculus (house mouse) ]

Gene ID: 20844, updated on 26-Sep-2022

Summary

Official Symbol
Stamprovided by MGI
Official Full Name
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1provided by MGI
Primary source
MGI:MGI:1329014
See related
Ensembl:ENSMUSG00000026718 AllianceGenome:MGI:1329014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STAM1
Summary
Predicted to enable ubiquitin-like protein ligase binding activity. Predicted to be involved in positive regulation of exosomal secretion; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; and regulation of extracellular exosome assembly. Predicted to act upstream of or within protein transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ESCRT-0 complex. Orthologous to human STAM (signal transducing adaptor molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 14.5), whole brain E14.5 (RPKM 13.8) and 28 other tissues See more
Orthologs
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Genomic context

See Stam in Genome Data Viewer
Location:
2; 2 A2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (14078910..14153296)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (14073962..14148338)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene signal transducing adaptor molecule (SH3 domain and ITAM motif) 1, opposite strand Neighboring gene transmembrane protein 236 Neighboring gene mannose receptor, C type 1 Neighboring gene microRNA 511

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ESCRT-0 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ESCRT-0 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
signal transducing adapter molecule 1
Names
STAM-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356337.1NP_001343266.1  signal transducing adapter molecule 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoforom 1.
    Source sequence(s)
    AL844560, AL845434
    Conserved Domains (2) summary
    cd11964
    Location:163217
    SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
    cl02544
    Location:192
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  2. NM_011484.3NP_035614.1  signal transducing adapter molecule 1 isoform 1

    See identical proteins and their annotated locations for NP_035614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK164191, AL845434, BC055326, BY087075
    Consensus CDS
    CCDS15698.1
    UniProtKB/Swiss-Prot
    P70297
    UniProtKB/TrEMBL
    Q3TQ49
    Related
    ENSMUSP00000100025.5, ENSMUST00000102960.11
    Conserved Domains (3) summary
    cd11964
    Location:213267
    SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
    cd03568
    Location:9142
    VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
    pfam03127
    Location:306377
    GAT; GAT domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    14078910..14153296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939213.1 RNA Sequence