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TARS2 threonyl-tRNA synthetase 2, mitochondrial [ Homo sapiens (human) ]

Gene ID: 80222, updated on 7-Jan-2024

Summary

Official Symbol
TARS2provided by HGNC
Official Full Name
threonyl-tRNA synthetase 2, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:30740
See related
Ensembl:ENSG00000143374 MIM:612805; AllianceGenome:HGNC:30740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
thrRS; TARSL1; COXPD21
Summary
This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in kidney (RPKM 7.6), heart (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

See TARS2 in Genome Data Viewer
Location:
1q21.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150487419..150507602)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149612277..149632442)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150459895..150480078)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1687 Neighboring gene regulation of nuclear pre-mRNA domain containing 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:150383836-150384059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150444960-150445472 Neighboring gene uncharacterized LOC124904416 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150459720-150460226 Neighboring gene microRNA 6878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150482970-150483840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1300 Neighboring gene extracellular matrix protein 1 Neighboring gene focally amplified long non-coding RNA in epithelial cancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150505206-150506196 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:150507812-150509011

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
threonine--tRNA ligase, mitochondrial
Names
threonyl-tRNA synthetase 2, mitochondrial (putative)
threonyl-tRNA synthetase-like 1
NP_001258824.1
NP_001258825.1
NP_079426.2
XP_006711618.1
XP_016857883.1
XP_016857884.1
XP_047286857.1
XP_054194838.1
XP_054194839.1
XP_054194840.1
XP_054194841.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034226.1 RefSeqGene

    Range
    5056..25239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001271895.2NP_001258824.1  threonine--tRNA ligase, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001258824.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the coding region, compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.
    Source sequence(s)
    AK225368, AK315507, CA426625, DB451526
    Consensus CDS
    CCDS60251.1
    UniProtKB/TrEMBL
    U3KQG0
    Related
    ENSP00000475847.1, ENST00000606933.5
    Conserved Domains (1) summary
    cl28417
    Location:17628
    ThrS; Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
  2. NM_001271896.2NP_001258825.1  threonine--tRNA ligase, mitochondrial isoform c

    See identical proteins and their annotated locations for NP_001258825.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks four exons in the coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
    Source sequence(s)
    AK022590, AK225368, CA426625
    Consensus CDS
    CCDS60252.1
    UniProtKB/Swiss-Prot
    Q9BW92
    Related
    ENSP00000358050.2, ENST00000369054.6
    Conserved Domains (1) summary
    cl28417
    Location:17580
    ThrS; Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
  3. NM_025150.5NP_079426.2  threonine--tRNA ligase, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_079426.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC007824, BC009997, BM974316, CA426625, DB451526
    Consensus CDS
    CCDS952.1
    UniProtKB/Swiss-Prot
    Q53GW7, Q96I50, Q9BW92, Q9H9V2
    Related
    ENSP00000358060.3, ENST00000369064.8
    Conserved Domains (5) summary
    cd01667
    Location:61122
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:17710
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:229252
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:300613
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:613704
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

RNA

  1. NR_073513.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites in internal exons and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY450558, BC000541, CN258895, DB451526, DB551795
    Related
    ENST00000369051.7
  2. NR_073514.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK022590, AK298773, BP308698, CA426625

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    150487419..150507602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711555.3XP_006711618.1  threonine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PLN02908
    Location:17676
    PLN02908; threonyl-tRNA synthetase
  2. XM_047430901.1XP_047286857.1  threonine--tRNA ligase, mitochondrial isoform X2

  3. XM_017002394.3XP_016857883.1  threonine--tRNA ligase, mitochondrial isoform X3

  4. XM_017002395.3XP_016857884.1  threonine--tRNA ligase, mitochondrial isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    149612277..149632442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338863.1XP_054194838.1  threonine--tRNA ligase, mitochondrial isoform X1

  2. XM_054338864.1XP_054194839.1  threonine--tRNA ligase, mitochondrial isoform X2

  3. XM_054338865.1XP_054194840.1  threonine--tRNA ligase, mitochondrial isoform X3

  4. XM_054338866.1XP_054194841.1  threonine--tRNA ligase, mitochondrial isoform X4