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TMEM134 transmembrane protein 134 [ Homo sapiens (human) ]

Gene ID: 80194, updated on 21-Mar-2023

Summary

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Official Symbol
TMEM134provided by HGNC
Official Full Name
transmembrane protein 134provided by HGNC
Primary source
HGNC:HGNC:26142
See related
Ensembl:ENSG00000172663 AllianceGenome:HGNC:26142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in cytosol and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 10.7), prostate (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

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See TMEM134 in Genome Data Viewer
Location:
11q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (67461710..67469251, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (67455835..67463377, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67229181..67236722, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type C associated protein Neighboring gene coronin 1B Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4 Neighboring gene aryl hydrocarbon receptor interacting protein Neighboring gene microRNA 6752 Neighboring gene phosphatidylinositol transfer protein membrane associated 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of transmembrane protein 134 as a novel LMP1-binding protein by using bimolecular fluorescence complementation and an enhanced retroviral mutagen. Talaty P, et al. J Virol, 2012 Oct. PMID 22855487, Free PMC Article
  2. Systematic identification of hepatitis E virus ORF2 interactome reveals that TMEM134 engages in ORF2-mediated NF-κB pathway. Tian Y, et al. Virus Res, 2017 Jan 15. PMID 27899274
  3. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. Passantino R, et al. Biochim Biophys Acta, 2013 Mar. PMID 23142642
  4. Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2. Snieder B, et al. SLAS Discov, 2019 Oct. PMID 31318583
  5. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. Schaafhausen A, et al. Thromb Haemost, 2011 Feb. PMID 21103663

See all (12) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. screen identified a novel LMP1-binding protein, transmembrane protein 134; Tmem134 affected LMP1-induced NF-kappaB induction
    Title: Identification of transmembrane protein 134 as a novel LMP1-binding protein by using bimolecular fluorescence complementation and an enhanced retroviral mutagen.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21749, MGC149891

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 134

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001078650.3 → NP_001072118.1  transmembrane protein 134 isoform b

    See identical proteins and their annotated locations for NP_001072118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AA830850, AP003419, BC125134, HY053672
    Consensus CDS
    CCDS41678.1
    UniProtKB/Swiss-Prot
    Q9H6X4
    Related
    ENSP00000377455.3, ENST00000393877.3
    Conserved Domains (1) summary
    pfam05915
    Location:57 → 178
    DUF872; Eukaryotic protein of unknown function (DUF872)

  2. NM_001078651.3 → NP_001072119.1  transmembrane protein 134 isoform c

    See identical proteins and their annotated locations for NP_001072119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AA830850, AP003419, BC013883, HY053672, HY059123
    UniProtKB/Swiss-Prot
    Q9H6X4
    Conserved Domains (1) summary
    pfam05915
    Location:57 → 184
    DUF872; Eukaryotic protein of unknown function (DUF872)

  3. NM_025124.4 → NP_079400.1  transmembrane protein 134 isoform a

    See identical proteins and their annotated locations for NP_079400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AA830850, AK025402, AP003419, HY053672
    Consensus CDS
    CCDS8167.1
    UniProtKB/Swiss-Prot
    Q6PJN3, Q9H6X4
    Related
    ENSP00000312615.2, ENST00000308022.7
    Conserved Domains (1) summary
    pfam05915
    Location:57 → 193
    DUF872; Eukaryotic protein of unknown function (DUF872)

RNA

  1. NR_073409.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA830850, AP003419, BC013883, HY053672

  2. NR_073410.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses alternate splice sites and lacks a 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA830850, AP003419, BC013883, BG719036

  3. NR_073411.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA830850, AP003419, BC013883, BM920758, HY053672

  4. NR_073412.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses alternate 3' splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC013883, BX400047, HY053672
    Related
    ENST00000545682.5

  5. NR_073413.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses alternate 5' and 3' splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA830850, AP003419, BC013883, CN336445, HY053672

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    67461710..67469251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545268.4 → XP_011543570.1  transmembrane protein 134 isoform X1

    Conserved Domains (1) summary
    pfam05915
    Location:57 → 128
    DUF872; Eukaryotic protein of unknown function (DUF872)

RNA

  1. XR_007062506.1 RNA Sequence

  2. XR_007062507.1 RNA Sequence

  3. XR_950064.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    67455835..67463377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370039.1 → XP_054226014.1  transmembrane protein 134 isoform X1

RNA

  1. XR_008488458.1 RNA Sequence

  2. XR_008488459.1 RNA Sequence

  3. XR_008488460.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6X4.1 GenPept UniProtKB/Swiss-Prot:Q9H6X4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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