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TMEM134 transmembrane protein 134 [ Homo sapiens (human) ]

Gene ID: 80194, updated on 24-Nov-2020

Summary

Official Symbol
TMEM134provided by HGNC
Official Full Name
transmembrane protein 134provided by HGNC
Primary source
HGNC:HGNC:26142
See related
Ensembl:ENSG00000172663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in skin (RPKM 10.7), prostate (RPKM 8.0) and 25 other tissues See more
Orthologs

Genomic context

See TMEM134 in Genome Data Viewer
Location:
11q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67461710..67469272, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67231819..67236748, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type C associated protein Neighboring gene coronin 1B Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4 Neighboring gene aryl hydrocarbon receptor interacting protein Neighboring gene microRNA 6752 Neighboring gene phosphatidylinositol transfer protein membrane associated 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21749, MGC149891

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001078650.3NP_001072118.1  transmembrane protein 134 isoform b

    See identical proteins and their annotated locations for NP_001072118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AA830850, AP003419, BC125134, HY053672
    Consensus CDS
    CCDS41678.1
    UniProtKB/Swiss-Prot
    Q9H6X4
    Related
    ENSP00000377455.3, ENST00000393877.3
    Conserved Domains (1) summary
    pfam05915
    Location:57178
    DUF872; Eukaryotic protein of unknown function (DUF872)
  2. NM_001078651.3NP_001072119.1  transmembrane protein 134 isoform c

    See identical proteins and their annotated locations for NP_001072119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AA830850, AP003419, BC013883, HY053672, HY059123
    UniProtKB/Swiss-Prot
    Q9H6X4
    Conserved Domains (1) summary
    pfam05915
    Location:57184
    DUF872; Eukaryotic protein of unknown function (DUF872)
  3. NM_025124.4NP_079400.1  transmembrane protein 134 isoform a

    See identical proteins and their annotated locations for NP_079400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AA830850, AK025402, AP003419, HY053672
    Consensus CDS
    CCDS8167.1
    UniProtKB/Swiss-Prot
    Q9H6X4
    Related
    ENSP00000312615.2, ENST00000308022.7
    Conserved Domains (1) summary
    pfam05915
    Location:57193
    DUF872; Eukaryotic protein of unknown function (DUF872)

RNA

  1. NR_073409.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA830850, AP003419, BC013883, HY053672
  2. NR_073410.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses alternate splice sites and lacks a 3' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA830850, AP003419, BC013883, BG719036
  3. NR_073411.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA830850, AP003419, BC013883, BM920758, HY053672
  4. NR_073412.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses alternate 3' splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC013883, BX400047, HY053672
  5. NR_073413.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses alternate 5' and 3' splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA830850, AP003419, BC013883, CN336445, HY053672

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    67461710..67469272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718693.2XP_006718756.1  transmembrane protein 134 isoform X3

    See identical proteins and their annotated locations for XP_006718756.1

    Conserved Domains (1) summary
    pfam05915
    Location:57169
    DUF872; Eukaryotic protein of unknown function (DUF872)
  2. XM_017018356.1XP_016873845.1  transmembrane protein 134 isoform X2

  3. XM_024448697.1XP_024304465.1  transmembrane protein 134 isoform X1

    Conserved Domains (1) summary
    pfam05915
    Location:136220
    DUF872; Eukaryotic protein of unknown function (DUF872)
  4. XM_011545268.3XP_011543570.1  transmembrane protein 134 isoform X4

    Conserved Domains (1) summary
    pfam05915
    Location:57128
    DUF872; Eukaryotic protein of unknown function (DUF872)

RNA

  1. XR_950061.1 RNA Sequence

  2. XR_950065.1 RNA Sequence

  3. XR_950062.3 RNA Sequence

  4. XR_001747983.2 RNA Sequence

    Related
    ENST00000545682.5
  5. XR_950064.3 RNA Sequence

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