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Tmem134 transmembrane protein 134 [ Mus musculus (house mouse) ]

Gene ID: 66990, updated on 26-Sep-2022

Summary

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Official Symbol
Tmem134provided by MGI
Official Full Name
transmembrane protein 134provided by MGI
Primary source
MGI:MGI:1914240
See related
Ensembl:ENSMUSG00000024845 AllianceGenome:MGI:1914240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410001H17Rik
Summary
Predicted to be located in cytosol and perinuclear region of cytoplasm. Is expressed in heart. Orthologous to human TMEM134 (transmembrane protein 134). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 74.0), adrenal adult (RPKM 71.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem134 in Genome Data Viewer
Location:
19; 19 A
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4175960..4182306)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4125960..4132307)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CDK2-associated protein 2 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 1 Neighboring gene aryl-hydrocarbon receptor-interacting protein Neighboring gene calcium binding protein 4 Neighboring gene G protein-coupled receptor 152

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Kalsotra A, et al. Proc Natl Acad Sci U S A, 2008 Dec 23. PMID 19075228, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 134

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001078649.1 → NP_001072117.1  transmembrane protein 134 isoform a

    See identical proteins and their annotated locations for NP_001072117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC109138, AI789565, CF983315
    UniProtKB/Swiss-Prot
    Q8R0J4, Q9CR66
    Related
    ENSMUSP00000159415.2, ENSMUST00000140267.10
    Conserved Domains (1) summary
    pfam05915
    Location:57 → 193
    DUF872; Eukaryotic protein of unknown function (DUF872)

  2. NM_025889.2 → NP_080165.1  transmembrane protein 134 isoform b

    See identical proteins and their annotated locations for NP_080165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AC109138, AK002220, CF983315
    UniProtKB/Swiss-Prot
    Q8R0J4
    Related
    ENSMUSP00000158987.4, ENSMUST00000150627.11
    Conserved Domains (1) summary
    pfam05915
    Location:57 → 178
    DUF872; Eukaryotic protein of unknown function (DUF872)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4175960..4182306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0J4.1 GenPept UniProtKB/Swiss-Prot:Q8R0J4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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