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BRD3 bromodomain containing 3 [ Homo sapiens (human) ]

Gene ID: 8019, updated on 21-Mar-2023

Summary

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Official Symbol
BRD3provided by HGNC
Official Full Name
bromodomain containing 3provided by HGNC
Primary source
HGNC:HGNC:1104
See related
Ensembl:ENSG00000169925 MIM:601541; AllianceGenome:HGNC:1104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORFX; FSHRG2; RING3L
Summary
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 8.0), brain (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

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See BRD3 in Genome Data Viewer
Location:
9q34.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (134030305..134068548, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (146246241..146284500, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136895427..136933148, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10163 Neighboring gene vav guanine nucleotide exchange factor 2 Neighboring gene Sharpr-MPRA regulatory region 14277 Neighboring gene uncharacterized LOC100130548 Neighboring gene BRD3 opposite strand Neighboring gene ADP ribosylation factor 4 pseudogene 1 Neighboring gene WD repeat domain 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair. Wang C, et al. DNA Repair (Amst), 2023 Feb. PMID 36608404
  2. Epigenetic readers and lung cancer: the rs2427964C>T variant of the bromodomain and extraterminal domain gene BRD3 is associated with poorer survival outcome in NSCLC. Lee JH, et al. Mol Oncol, 2022 Feb. PMID 34605158, Free PMC Article
  3. The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators. Wai DCC, et al. J Biol Chem, 2018 May 11. PMID 29567837, Free PMC Article
  4. The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis. Shao Z, et al. Nat Commun, 2016 Mar 7. PMID 26947130, Free PMC Article
  5. Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function. Kim HS, et al. Cell Rep, 2014 Mar 13. PMID 24565511, Free PMC Article

See all (92) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair.
    Title: Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair.
  2. Epigenetic readers and lung cancer: the rs2427964C>T variant of the bromodomain and extraterminal domain gene BRD3 is associated with poorer survival outcome in NSCLC.
    Title: Epigenetic readers and lung cancer: the rs2427964C>T variant of the bromodomain and extraterminal domain gene BRD3 is associated with poorer survival outcome in NSCLC.
  3. A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.
    Title: A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.
  4. BCL6 confers KRAS-mutant non-small-cell lung cancer resistance to BET inhibitors.
    Title: BCL6 confers KRAS-mutant non-small-cell lung cancer resistance to BET inhibitors.
  5. Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.
    Title: Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.
  6. BRD3 is recruited to and controls the activity of a subset ERa transcriptional enhancers, providing a therapeutic opportunity to target BRD3 with BET inhibitors in ERa-positive breast cancers.
    Title: Distinct Roles for BET Family Members in Estrogen Receptor α Enhancer Function and Gene Regulation in Breast Cancer Cells.
  7. This study presents the first co-crystal structure of SPOP and a bromodomain containing protein (BRD3).
    Title: Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.
  8. The BET proteins Brd3 and Brd4 were shown to bind to the NOX4 promoter and drive TGF-beta-induced NOX4 expression. Our data indicate a critical role of BET proteins in promoting redox imbalance and pulmonary myofibroblast activation and support BET bromodomain inhibitors as a potential therapy for fibrotic lung disease.
    Title: Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation.
  9. Results provide evidence that both BRD3 and BRD4 are repressors of epithelial-to-mesenchymal transition in breast cancer cells.
    Title: BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition.
  10. Recruitment of Brd3 (and Brd4) to chromatin is essential for inflammation mediator-induced matrix-degrading enzyme expression.
    Title: Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
New gene functions in megakaryopoiesis and platelet formation.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23227, FLJ41328, KIAA0043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bromodomain-containing protein 3
Names
RING3-like protein
female sterile homeotic related gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007371.4 → NP_031397.1  bromodomain-containing protein 3

    See identical proteins and their annotated locations for NP_031397.1

    Status: REVIEWED

    Source sequence(s)
    AA766480, AK026880, AK123322, AL591386, BC010699, BI545861, D26362, DW413353
    Consensus CDS
    CCDS6980.1
    UniProtKB/Swiss-Prot
    Q15059, Q92645
    UniProtKB/TrEMBL
    A0A024R8H6
    Related
    ENSP00000305918.6, ENST00000303407.12
    Conserved Domains (3) summary
    cd05497
    Location:34 → 140
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:311 → 412
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:571 → 635
    BET; Bromodomain extra-terminal - transcription regulation

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    134030305..134068548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423906.1 → XP_047279862.1  bromodomain-containing protein 3 isoform X2

  2. XM_047423903.1 → XP_047279859.1  bromodomain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q92645
    UniProtKB/TrEMBL
    A0A024R8H6

  3. XM_047423905.1 → XP_047279861.1  bromodomain-containing protein 3 isoform X2

  4. XM_006717291.4 → XP_006717354.1  bromodomain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006717354.1

    UniProtKB/Swiss-Prot
    Q15059, Q92645
    UniProtKB/TrEMBL
    A0A024R8H6
    Conserved Domains (3) summary
    cd05497
    Location:34 → 140
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:311 → 412
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:571 → 635
    BET; Bromodomain extra-terminal - transcription regulation

  5. XM_017015165.3 → XP_016870654.1  bromodomain-containing protein 3 isoform X2

    Conserved Domains (3) summary
    cd05497
    Location:34 → 140
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:311 → 412
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:571 → 635
    BET; Bromodomain extra-terminal - transcription regulation

  6. XM_047423904.1 → XP_047279860.1  bromodomain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q92645
    UniProtKB/TrEMBL
    A0A024R8H6

  7. XM_011519052.3 → XP_011517354.1  bromodomain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011517354.1

    UniProtKB/Swiss-Prot
    Q15059, Q92645
    UniProtKB/TrEMBL
    A0A024R8H6
    Conserved Domains (3) summary
    cd05497
    Location:34 → 140
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:311 → 412
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:571 → 635
    BET; Bromodomain extra-terminal - transcription regulation

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    146246241..146284500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363877.1 → XP_054219852.1  bromodomain-containing protein 3 isoform X1

  2. XM_054363876.1 → XP_054219851.1  bromodomain-containing protein 3 isoform X1

  3. XM_054363880.1 → XP_054219855.1  bromodomain-containing protein 3 isoform X2

  4. XM_054363879.1 → XP_054219854.1  bromodomain-containing protein 3 isoform X2

  5. XM_054363878.1 → XP_054219853.1  bromodomain-containing protein 3 isoform X2

  6. XM_054363874.1 → XP_054219849.1  bromodomain-containing protein 3 isoform X1

  7. XM_054363875.1 → XP_054219850.1  bromodomain-containing protein 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15059.1 GenPept UniProtKB/Swiss-Prot:Q15059

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