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BRD3 bromodomain containing 3 [ Homo sapiens (human) ]

Gene ID: 8019, updated on 5-Aug-2018

Summary

Official Symbol
BRD3provided by HGNC
Official Full Name
bromodomain containing 3provided by HGNC
Primary source
HGNC:HGNC:1104
See related
Ensembl:ENSG00000169925 MIM:601541; Vega:OTTHUMG00000021004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORFX; RING3L
Summary
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 8.0), brain (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See BRD3 in Genome Data Viewer
Location:
9q34.2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (134030305..134068533, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136895427..136933655, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene SARDH intron CAGE-defined T cell enhancer Neighboring gene sarcosine dehydrogenase Neighboring gene vav guanine nucleotide exchange factor 2 Neighboring gene uncharacterized LOC100130548 Neighboring gene BRD3 opposite strand Neighboring gene ADP ribosylation factor 4 pseudogene 1 Neighboring gene WD repeat domain 5

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23227, FLJ41328, KIAA0043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bromodomain-containing protein 3
Names
RING3-like protein
bromodomain-containing protein 3 short isoform

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007371.3NP_031397.1  bromodomain-containing protein 3

    See identical proteins and their annotated locations for NP_031397.1

    Status: REVIEWED

    Source sequence(s)
    AA766480, AK026880, AK123322, BC010699, BI545861, D26362, DW413353
    Consensus CDS
    CCDS6980.1
    UniProtKB/Swiss-Prot
    Q15059
    UniProtKB/TrEMBL
    A0A024R8H6
    Related
    ENSP00000305918.6, OTTHUMP00000022724, ENST00000303407.11, OTTHUMT00000055390
    Conserved Domains (3) summary
    cd05497
    Location:34140
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:311412
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:571635
    BET; Bromodomain extra-terminal - transcription regulation

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    134030305..134068533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717291.3XP_006717354.1  bromodomain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006717354.1

    UniProtKB/Swiss-Prot
    Q15059
    UniProtKB/TrEMBL
    A0A024R8H6
    Conserved Domains (3) summary
    cd05497
    Location:34140
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:311412
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:571635
    BET; Bromodomain extra-terminal - transcription regulation
  2. XM_017015165.2XP_016870654.1  bromodomain-containing protein 3 isoform X2

    Conserved Domains (3) summary
    cd05497
    Location:34140
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:311412
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:571635
    BET; Bromodomain extra-terminal - transcription regulation
  3. XM_017015166.2XP_016870655.1  bromodomain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    B4DS09
    Conserved Domains (2) summary
    cd05498
    Location:191
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:250314
    BET; Bromodomain extra-terminal - transcription regulation
  4. XM_011519052.2XP_011517354.1  bromodomain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011517354.1

    UniProtKB/Swiss-Prot
    Q15059
    UniProtKB/TrEMBL
    A0A024R8H6
    Conserved Domains (3) summary
    cd05497
    Location:34140
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:311412
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:571635
    BET; Bromodomain extra-terminal - transcription regulation
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