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Brd3 bromodomain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 67382, updated on 9-May-2024

Summary

Official Symbol
Brd3provided by MGI
Official Full Name
bromodomain containing 3provided by MGI
Primary source
MGI:MGI:1914632
See related
Ensembl:ENSMUSG00000026918 AllianceGenome:MGI:1914632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORFX; Fsrg2; RINGL3; 2410084F24Rik
Summary
Predicted to enable lysine-acetylated histone binding activity and nucleosomal histone binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and retina. Orthologous to human BRD3 (bromodomain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 15.9), limb E14.5 (RPKM 14.1) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2 A3; 2 19.38 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27335588..27397669, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27445576..27507657, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene vav 2 oncogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27159262-27159371 Neighboring gene Vav2R10 erythroid cis-regulatory module Neighboring gene Vav2R3 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_04000 Neighboring gene Vav2R7 erythroid cis-regulatory module Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27269900-27270101 Neighboring gene STARR-seq mESC enhancer starr_04002 Neighboring gene Vav2R5 erythroid cis-regulatory module Neighboring gene bromodomain containing 3, opposite strand Neighboring gene microRNA 7578 Neighboring gene makorin, ring finger protein, 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04005 Neighboring gene STARR-seq mESC enhancer starr_04007 Neighboring gene predicted gene, 54108 Neighboring gene STARR-positive B cell enhancer mm9_chr2:27395293-27395594 Neighboring gene WD repeat domain 5 Neighboring gene predicted gene, 25541

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables lncRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bromodomain-containing protein 3
Names
bromodomain-containing FSH-like protein FSRG2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113573.1NP_001107045.1  bromodomain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001107045.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal coding exon, as compared to vairant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK034797, AK079666, AK160752, BM899753, BY064662
    Consensus CDS
    CCDS15828.1
    UniProtKB/Swiss-Prot
    Q8C665, Q8CAX7, Q8K2F0, Q9JI25
    UniProtKB/TrEMBL
    Q3TUI3, Q4G5Y4
    Related
    ENSMUSP00000076918.7, ENSMUST00000077737.13
    Conserved Domains (3) summary
    cd05497
    Location:33139
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:310411
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:572636
    BET; Bromodomain extra-terminal - transcription regulation
  2. NM_001113574.1NP_001107046.1  bromodomain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001107046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK034797, AK037435, AK076472, AK079666, AK160752, BM899753, BY064662
    Consensus CDS
    CCDS50546.1
    UniProtKB/TrEMBL
    A2AKA9, Q5CCJ9
    Related
    ENSMUSP00000109574.3, ENSMUST00000113941.9
    Conserved Domains (3) summary
    cd05497
    Location:33139
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:310411
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:589653
    BET; Bromodomain extra-terminal - transcription regulation
  3. NM_023336.4NP_075825.3  bromodomain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_075825.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR and lacks an internal coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK034797, AK079666, AK160752, BE981816, BM899753, CN530570
    Consensus CDS
    CCDS15828.1
    UniProtKB/Swiss-Prot
    Q8C665, Q8CAX7, Q8K2F0, Q9JI25
    UniProtKB/TrEMBL
    Q3TUI3, Q4G5Y4
    Related
    ENSMUSP00000028282.9, ENSMUST00000028282.15
    Conserved Domains (3) summary
    cd05497
    Location:33139
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:310411
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:572636
    BET; Bromodomain extra-terminal - transcription regulation

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    27335588..27397669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498250.2XP_006498313.1  bromodomain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006498313.1

    UniProtKB/TrEMBL
    A2AKA9, Q5CCJ9
    Related
    ENSMUSP00000114422.2, ENSMUST00000154316.8
    Conserved Domains (3) summary
    cd05497
    Location:33139
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:310411
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:589653
    BET; Bromodomain extra-terminal - transcription regulation
  2. XM_006498249.5XP_006498312.1  bromodomain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006498312.1

    UniProtKB/TrEMBL
    A2AKA9, Q5CCJ9
    Conserved Domains (3) summary
    cd05497
    Location:33139
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:310411
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:589653
    BET; Bromodomain extra-terminal - transcription regulation
  3. XM_011239156.4XP_011237458.1  bromodomain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011237458.1

    UniProtKB/TrEMBL
    A2AKA9, Q5CCJ9
    Conserved Domains (3) summary
    cd05497
    Location:33139
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:310411
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:589653
    BET; Bromodomain extra-terminal - transcription regulation
  4. XM_011239155.2XP_011237457.1  bromodomain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011237457.1

    UniProtKB/TrEMBL
    A2AKA9, Q5CCJ9
    Conserved Domains (3) summary
    cd05497
    Location:33139
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:310411
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:589653
    BET; Bromodomain extra-terminal - transcription regulation
  5. XM_011239158.4XP_011237460.1  bromodomain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011237460.1

    UniProtKB/TrEMBL
    A2AKA9, Q5CCJ9
    Conserved Domains (3) summary
    cd05497
    Location:33139
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:310411
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:589653
    BET; Bromodomain extra-terminal - transcription regulation
  6. XM_011239159.2XP_011237461.1  bromodomain-containing protein 3 isoform X3

    Conserved Domains (2) summary
    cd05498
    Location:191
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:269333
    BET; Bromodomain extra-terminal - transcription regulation
  7. XM_030251992.2XP_030107852.1  bromodomain-containing protein 3 isoform X4

    Conserved Domains (2) summary
    cd05498
    Location:191
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:252316
    BET; Bromodomain extra-terminal - transcription regulation
  8. XM_030251991.2XP_030107851.1  bromodomain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q8C665, Q8CAX7, Q8K2F0, Q9JI25
    UniProtKB/TrEMBL
    Q3TUI3, Q4G5Y4
    Related
    ENSMUSP00000128812.2, ENSMUST00000164296.8
    Conserved Domains (3) summary
    cd05497
    Location:33139
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:310411
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    pfam17035
    Location:572636
    BET; Bromodomain extra-terminal - transcription regulation