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MOGAT2 monoacylglycerol O-acyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 80168, updated on 23-Nov-2021

Summary

Official Symbol
MOGAT2provided by HGNC
Official Full Name
monoacylglycerol O-acyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:23248
See related
Ensembl:ENSG00000166391 MIM:610270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hDC5; MGAT2; DGAT2L5; DGAT2L5.
Summary
The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]
Annotation information
Note: MGAT2 (Gene ID: 4247) and MOGAT2 (Gene ID: 80168) share the MGAT2 symbol/alias in common. MGAT2 is a widely used alternative name for monoacylglycerol O-acyltransferase 2 (MOGAT2), which can be confused with the official symbol for MGAT2, mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase. [25 Jun 2018]
Expression
Biased expression in small intestine (RPKM 52.4), duodenum (RPKM 48.1) and 2 other tissues See more
Orthologs
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Genomic context

See MOGAT2 in Genome Data Viewer
Location:
11q13.5
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (75717819..75732953)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (75428883..75443998)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369391 Neighboring gene microtubule associated protein 6 Neighboring gene ribosomal protein L37 pseudogene Neighboring gene uncharacterized LOC105369392 Neighboring gene uncharacterized LOC105369393 Neighboring gene RNA, 7SL, cytoplasmic 786, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22644, MGC119183, MGC119184, MGC119185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2-acylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 2-acylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 2-acylglycerol O-acyltransferase activity TAS
Traceable Author Statement
more info
 
enables O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in diacylglycerol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intestinal absorption IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in monoacylglycerol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
2-acylglycerol O-acyltransferase 2
Names
acyl-CoA:monoacylglycerol acyltransferase 2
diacylglycerol O-acyltransferase candidate 5
diacylglycerol acyltransferase 2-like protein 5
NP_079374.2
XP_011543569.1
XP_024304464.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025098.4NP_079374.2  2-acylglycerol O-acyltransferase 2

    See identical proteins and their annotated locations for NP_079374.2

    Status: REVIEWED

    Source sequence(s)
    AK000245, AK291998, DA922421
    Consensus CDS
    CCDS8240.1
    UniProtKB/Swiss-Prot
    Q3SYC2
    Related
    ENSP00000198801.5, ENST00000198801.10
    Conserved Domains (1) summary
    cl17185
    Location:41333
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    75717819..75732953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545267.1XP_011543569.1  2-acylglycerol O-acyltransferase 2 isoform X1

    Conserved Domains (1) summary
    cl17185
    Location:41297
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
  2. XM_024448696.1XP_024304464.1  2-acylglycerol O-acyltransferase 2 isoform X2

    Conserved Domains (1) summary
    cl17185
    Location:3215
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
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