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CWH43 cell wall biogenesis 43 C-terminal homolog [ Homo sapiens (human) ]

Gene ID: 80157, updated on 23-Nov-2023

Summary

Official Symbol
CWH43provided by HGNC
Official Full Name
cell wall biogenesis 43 C-terminal homologprovided by HGNC
Primary source
HGNC:HGNC:26133
See related
Ensembl:ENSG00000109182 MIM:618561; AllianceGenome:HGNC:26133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CWH43-C; PGAP2IP
Summary
Predicted to be involved in GPI anchor biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in prostate (RPKM 20.1), skin (RPKM 10.7) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CWH43 in Genome Data Viewer
Location:
4p11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (48986275..49062079)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (48952880..49028711)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48988292..49064096)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene RNA, U6 small nuclear 158, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21551 Neighboring gene triosephosphate isomerase 1 pseudogene 4 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49092970-49093748 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49093749-49094527 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49094528-49095306 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49095307-49096084 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49096085-49096864 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49096865-49097642 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49097643-49098421 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49098422-49099199 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49099200-49099978 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49099979-49100757 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49100758-49101536 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49101537-49102314 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49102315-49103094 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49103095-49103872 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49103873-49104650 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49104651-49105428 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49105429-49106208 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49106209-49106986 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49106987-49107766 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49107767-49108544 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49108545-49109324 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49109325-49110102 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49110103-49110880 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49110881-49111658 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49111659-49112438 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49112439-49113216 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49113217-49113994 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49113995-49114772 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49115553-49116330 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49114773-49115552 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49116331-49117108 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49117109-49117886 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49118401-49119098 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49119099-49119795 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49119796-49120492 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49120493-49121189 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49121190-49121887 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49121888-49122584 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49122585-49123281 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49123282-49123977 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49124676-49125372 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49123978-49124675 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49125373-49126070 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49126071-49126766 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49126767-49127464 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49127465-49128160 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49128161-49128857 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49128858-49129553 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49131647-49132342 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49132343-49133040 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49133737-49134434 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49134435-49135130 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49135131-49135828 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49135829-49136524 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49136525-49137222 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49137223-49137918 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49139313-49140009 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49140010-49140705 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49140766-49141340 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49141341-49141914 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49143063-49143636 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49142489-49143062 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:49143637-49144210 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49144785-49145357 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49145444-49146282 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49146283-49147119 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49147120-49147957 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:49147958-49148794 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49148795-49149632 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49149633-49150470 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49150471-49151308 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49151309-49152144 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:49152255-49152881 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:49152882-49153507 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49153693-49154210 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49154805-49155794 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49155795-49156783 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:49156784-49157772 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:49157773-49158761 Neighboring gene uncharacterized LOC101927209 Neighboring gene OCT4 hESC enhancer GRCh37_chr4:49168367-49168868 Neighboring gene sorting nexin 18 pseudogene Neighboring gene sorting nexin 18 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21511

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PGAP2-interacting protein
Names
cell wall biogenesis protein 43 C-terminal homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286791.2NP_001273720.1  PGAP2-interacting protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon and a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC020593, AK025164, AK300495, AK316307
    Consensus CDS
    CCDS68697.1
    UniProtKB/TrEMBL
    B7ZAJ2, E7EQL2
    Related
    ENSP00000422802.1, ENST00000513409.1
    Conserved Domains (2) summary
    pfam03372
    Location:424553
    Exo_endo_phos; Endonuclease/Exonuclease/phosphatase family
    cl00415
    Location:92276
    CobS; Cobalamin-5-phosphate synthase
  2. NM_025087.3NP_079363.2  PGAP2-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_079363.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC020593, AI377551, AK025164, DA426878
    Consensus CDS
    CCDS3486.1
    UniProtKB/Swiss-Prot
    B2RPD7, Q9H720
    UniProtKB/TrEMBL
    B7ZAJ2
    Related
    ENSP00000226432.4, ENST00000226432.9
    Conserved Domains (2) summary
    pfam03372
    Location:451580
    Exo_endo_phos; Endonuclease/Exonuclease/phosphatase family
    cl00415
    Location:119303
    CobS; Cobalamin-5-phosphate synthase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    48986275..49062079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513755.2XP_011512057.1  PGAP2-interacting protein isoform X1

    UniProtKB/TrEMBL
    B7ZAJ2
    Conserved Domains (2) summary
    pfam03372
    Location:451579
    Exo_endo_phos; Endonuclease/Exonuclease/phosphatase family
    cl00415
    Location:119303
    CobS; Cobalamin-5-phosphate synthase
  2. XM_011513758.2XP_011512060.1  PGAP2-interacting protein isoform X3

    UniProtKB/TrEMBL
    B7ZAJ2
    Conserved Domains (1) summary
    pfam03372
    Location:365493
    Exo_endo_phos; Endonuclease/Exonuclease/phosphatase family
  3. XM_011513757.3XP_011512059.1  PGAP2-interacting protein isoform X2

    See identical proteins and their annotated locations for XP_011512059.1

    UniProtKB/TrEMBL
    B7ZAJ2
    Conserved Domains (2) summary
    pfam03372
    Location:424552
    Exo_endo_phos; Endonuclease/Exonuclease/phosphatase family
    cl00415
    Location:92276
    CobS; Cobalamin-5-phosphate synthase
  4. XM_011513756.4XP_011512058.1  PGAP2-interacting protein isoform X2

    See identical proteins and their annotated locations for XP_011512058.1

    UniProtKB/TrEMBL
    B7ZAJ2
    Conserved Domains (2) summary
    pfam03372
    Location:424552
    Exo_endo_phos; Endonuclease/Exonuclease/phosphatase family
    cl00415
    Location:92276
    CobS; Cobalamin-5-phosphate synthase
  5. XM_011513759.1XP_011512061.1  PGAP2-interacting protein isoform X4

    Conserved Domains (2) summary
    pfam01006
    Location:746
    HCV_NS4a; Hepatitis C virus non-structural protein NS4a
    pfam03372
    Location:263391
    Exo_endo_phos; Endonuclease/Exonuclease/phosphatase family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    48952880..49028711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350891.1XP_054206866.1  PGAP2-interacting protein isoform X1

    UniProtKB/TrEMBL
    B7ZAJ2
  2. XM_054350894.1XP_054206869.1  PGAP2-interacting protein isoform X3

    UniProtKB/TrEMBL
    B7ZAJ2
  3. XM_054350893.1XP_054206868.1  PGAP2-interacting protein isoform X2

    UniProtKB/TrEMBL
    B7ZAJ2
  4. XM_054350892.1XP_054206867.1  PGAP2-interacting protein isoform X2

    UniProtKB/TrEMBL
    B7ZAJ2
  5. XM_054350895.1XP_054206870.1  PGAP2-interacting protein isoform X4