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TRIM46 tripartite motif containing 46 [ Homo sapiens (human) ]

Gene ID: 80128, updated on 11-Jul-2021

Summary

Official Symbol
TRIM46provided by HGNC
Official Full Name
tripartite motif containing 46provided by HGNC
Primary source
HGNC:HGNC:19019
See related
Ensembl:ENSG00000163462 MIM:600986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GENEY; TRIFIC
Expression
Broad expression in brain (RPKM 2.5), testis (RPKM 0.9) and 14 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See TRIM46 in Genome Data Viewer
Location:
1q22
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155173381..155184971)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155146325..155157447)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 18 Neighboring gene keratinocyte associated protein 2 Neighboring gene mucin 1, cell surface associated Neighboring gene microRNA 92b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23229, FLJ33185, FLJ98678

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in anterograde synaptic vesicle transport IEA
Inferred from Electronic Annotation
more info
 
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of anterograde dense core granule transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to axon IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cellular protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in axon initial segment IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in main axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in proximal neuron projection IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 46
Names
gene Y protein
tripartite, fibronectin type-III and C-terminal SPRY motif protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256599.2NP_001243528.1  tripartite motif-containing protein 46 isoform 2

    See identical proteins and their annotated locations for NP_001243528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK096158, AK128139, AK308075, DA509424, DB326530
    Consensus CDS
    CCDS58033.1
    UniProtKB/Swiss-Prot
    Q7Z4K8
    Related
    ENSP00000357366.1, ENST00000368382.5
    Conserved Domains (6) summary
    cd00063
    Location:421502
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12895
    Location:509718
    SPRY_PRY_TRIM46; PRY/SPRY domain in tripartite motif-containing protein 46 (TRIM46)
    pfam00643
    Location:199240
    zf-B_box; B-box zinc finger
    cd16757
    Location:438
    RING-HC_TRIM46; RING finger, HC subclass, found in tripartite motif-containing protein 46 (TRIM46) and similar proteins
    cl25407
    Location:247372
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    cl28410
    Location:173
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  2. NM_001256601.1NP_001243530.1  tripartite motif-containing protein 46 isoform 4

    See identical proteins and their annotated locations for NP_001243530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK128139, AK309699, DB326530
    Consensus CDS
    CCDS72931.1
    UniProtKB/Swiss-Prot
    Q7Z4K8
    UniProtKB/TrEMBL
    A0A087WUH1
    Related
    ENSP00000478669.1, ENST00000611379.1
    Conserved Domains (6) summary
    cd00063
    Location:431512
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12895
    Location:519728
    SPRY_PRY_TRIM46; PRY/SPRY domain in tripartite motif-containing protein 46 (TRIM46)
    pfam00643
    Location:209250
    zf-B_box; B-box zinc finger
    cd16757
    Location:1448
    RING-HC_TRIM46; RING finger, HC subclass, found in tripartite motif-containing protein 46 (TRIM46) and similar proteins
    cl25407
    Location:257382
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    cl28410
    Location:883
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  3. NM_001282378.2NP_001269307.1  tripartite motif-containing protein 46 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (5) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK128139, AK297318, BX283909, DA509424, DB326530
    Consensus CDS
    CCDS72932.1
    UniProtKB/Swiss-Prot
    Q7Z4K8
    UniProtKB/TrEMBL
    B7Z4F9, F5GYK0
    Related
    ENSP00000440254.1, ENST00000545012.5
    Conserved Domains (6) summary
    smart00502
    Location:144269
    BBC; B-Box C-terminal domain
    cd00063
    Location:318399
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12895
    Location:406615
    SPRY_PRY_TRIM46; PRY/SPRY domain in tripartite motif-containing protein 46 (TRIM46)
    cd19786
    Location:97142
    Bbox2_TRIM46_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 46 (TRIM46) and similar proteins
    cd19849
    Location:4394
    Bbox1_TRIM46_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 46 (TRIM46) and similar proteins
    pfam18568
    Location:247296
    COS; TRIM C-terminal subgroup One Signature domain
  4. NM_001282379.2NP_001269308.1  tripartite motif-containing protein 46 isoform 6

    See identical proteins and their annotated locations for NP_001269308.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate 3' exon structure and thus differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (6) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK026882, AL713999, DA509424, DB262381
    Consensus CDS
    CCDS60285.1
    UniProtKB/Swiss-Prot
    Q7Z4K8
    Related
    ENSP00000357369.4, ENST00000368385.8
    Conserved Domains (4) summary
    cd00063
    Location:444525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:3363
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:222263
    zf-B_box; B-box zinc finger
    cl23765
    Location:270395
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  5. NM_025058.5NP_079334.3  tripartite motif-containing protein 46 isoform 1

    See identical proteins and their annotated locations for NP_079334.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK096158, AY251386, DA509424, DB262381, DB326530
    Consensus CDS
    CCDS1097.1
    UniProtKB/Swiss-Prot
    Q7Z4K8
    Related
    ENSP00000334657.4, ENST00000334634.9
    Conserved Domains (6) summary
    cd00063
    Location:444525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12895
    Location:532741
    SPRY_PRY_TRIM46; PRY/SPRY domain in tripartite motif-containing protein 46 (TRIM46)
    pfam00643
    Location:222263
    zf-B_box; B-box zinc finger
    cd16757
    Location:2761
    RING-HC_TRIM46; RING finger, HC subclass, found in tripartite motif-containing protein 46 (TRIM46) and similar proteins
    cl25407
    Location:270395
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    cl28410
    Location:2296
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

RNA

  1. NR_046327.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK128139, BC143828, DA509424, DB326530
  2. NR_046329.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an exon and includes three alternate exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK128139, AL713999, CN259033, DB326530
    Related
    ENST00000468878.1
  3. NR_104150.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate, internal exon and an alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK026882, AL713999, BC069568, DA509424

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    155173381..155184971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449915.1XP_024305683.1  tripartite motif-containing protein 46 isoform X3

    Conserved Domains (6) summary
    cd00063
    Location:451532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12895
    Location:539748
    SPRY_PRY_TRIM46; PRY/SPRY domain in tripartite motif-containing protein 46 (TRIM46)
    pfam00643
    Location:229270
    zf-B_box; B-box zinc finger
    cd16757
    Location:3468
    RING-HC_TRIM46; RING finger, HC subclass, found in tripartite motif-containing protein 46 (TRIM46) and similar proteins
    cl25407
    Location:277402
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    cl28410
    Location:29103
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  2. XM_017002393.1XP_016857882.1  tripartite motif-containing protein 46 isoform X4

    Related
    ENSP00000376245.3, ENST00000392451.6
    Conserved Domains (5) summary
    cd00063
    Location:431512
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:2050
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:209250
    zf-B_box; B-box zinc finger
    cd12895
    Location:519728
    SPRY_PRY_TRIM46; PRY/SPRY domain in tripartite motif-containing protein 46 (TRIM46)
    cl23765
    Location:257382
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  3. XM_011510002.2XP_011508304.1  tripartite motif-containing protein 46 isoform X1

    Conserved Domains (5) summary
    cd00063
    Location:473554
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:6292
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:251292
    zf-B_box; B-box zinc finger
    cd12895
    Location:561770
    SPRY_PRY_TRIM46; PRY/SPRY domain in tripartite motif-containing protein 46 (TRIM46)
    cl23765
    Location:299424
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  4. XM_024449914.1XP_024305682.1  tripartite motif-containing protein 46 isoform X2

    Conserved Domains (6) summary
    cd00063
    Location:473554
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12895
    Location:561770
    SPRY_PRY_TRIM46; PRY/SPRY domain in tripartite motif-containing protein 46 (TRIM46)
    pfam00643
    Location:251292
    zf-B_box; B-box zinc finger
    cd16757
    Location:5690
    RING-HC_TRIM46; RING finger, HC subclass, found in tripartite motif-containing protein 46 (TRIM46) and similar proteins
    cl25407
    Location:299424
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    cl28410
    Location:51125
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

RNA

  1. XR_002957635.1 RNA Sequence

  2. XR_001737435.1 RNA Sequence

  3. XR_001737433.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001256600.1: Suppressed sequence

    Description
    NM_001256600.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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