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DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 [ Homo sapiens (human) ]

Gene ID: 79982, updated on 10-Dec-2019

Summary

Official Symbol
DNAJB14provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B14provided by HGNC
Primary source
HGNC:HGNC:25881
See related
Ensembl:ENSG00000164031 MIM:617487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGNR9427; PRO34683
Expression
Ubiquitous expression in brain (RPKM 7.8), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See DNAJB14 in Genome Data Viewer
Location:
4q23
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (99896248..99946713, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (100817405..100867883, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene dual adaptor of phosphotyrosine and 3-phosphoinositides 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene H2AZ1 divergent transcript Neighboring gene H2A.Z variant histone 1 Neighboring gene ribosomal protein L7 like 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14281, FLJ37755, MGC22187

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to misfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily B member 14
Names
DnaJ (Hsp40) homolog, subfamily B, member 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031723.4NP_001026893.1  dnaJ homolog subfamily B member 14 isoform 1

    See identical proteins and their annotated locations for NP_001026893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC097460, AL121021, AP001962, AY358272, BC022248, DA854416
    Consensus CDS
    CCDS34035.1
    UniProtKB/Swiss-Prot
    Q8TBM8
    Related
    ENSP00000404381.2, ENST00000442697.7
    Conserved Domains (2) summary
    COG0484
    Location:107214
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam09320
    Location:271371
    DUF1977; Domain of unknown function (DUF1977)
  2. NM_001278310.2NP_001265239.1  dnaJ homolog subfamily B member 14 isoform 2

    See identical proteins and their annotated locations for NP_001265239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate upstream start codon. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC097460, AL121021, AL833412, AP001962, AY358272, DA854416
    UniProtKB/Swiss-Prot
    Q8TBM8
    Conserved Domains (2) summary
    COG0484
    Location:40147
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam09320
    Location:204304
    DUF1977; Domain of unknown function (DUF1977)
  3. NM_001278311.2NP_001265240.1  dnaJ homolog subfamily B member 14 isoform 3

    See identical proteins and their annotated locations for NP_001265240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains two alternate 3' exons, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC097460, BF307232, DA854416
    Consensus CDS
    CCDS75171.1
    UniProtKB/TrEMBL
    A0A087WWX2
    Related
    ENSP00000480565.1, ENST00000610281.1
    Conserved Domains (1) summary
    cl26155
    Location:850
    BamD; BamD lipoprotein, a component of the beta-barrel assembly machinery

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    99896248..99946713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008628.2XP_016864117.1  dnaJ homolog subfamily B member 14 isoform X2

    Conserved Domains (3) summary
    COG0484
    Location:19126
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:2081
    DnaJ; DnaJ domain
    pfam09320
    Location:183283
    DUF1977; Domain of unknown function (DUF1977)
  2. XM_011532262.3XP_011530564.1  dnaJ homolog subfamily B member 14 isoform X1

    See identical proteins and their annotated locations for XP_011530564.1

    UniProtKB/Swiss-Prot
    Q8TBM8
    UniProtKB/TrEMBL
    A0A024RDI9
    Conserved Domains (3) summary
    COG0484
    Location:22129
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:2384
    DnaJ; DnaJ domain
    pfam09320
    Location:186286
    DUF1977; Domain of unknown function (DUF1977)

RNA

  1. XR_001741327.1 RNA Sequence

  2. XR_938772.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024920.3: Suppressed sequence

    Description
    NM_024920.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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