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DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 [ Homo sapiens (human) ]

Gene ID: 79982, updated on 4-Dec-2022

Summary

Official Symbol
DNAJB14provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B14provided by HGNC
Primary source
HGNC:HGNC:25881
See related
Ensembl:ENSG00000164031 MIM:617487; AllianceGenome:HGNC:25881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGNR9427; PRO34683
Summary
Enables Hsp70 protein binding activity. Involved in cellular protein-containing complex assembly and chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 7.8), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs
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Genomic context

See DNAJB14 in Genome Data Viewer
Location:
4q23
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (99896248..99946618, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (103211731..103262102, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (100817405..100867775, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene dual adaptor of phosphotyrosine and 3-phosphoinositides 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene H2AZ1 divergent transcript Neighboring gene H2A.Z variant histone 1 Neighboring gene ribosomal protein L7 like 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14281, FLJ37755, MGC22187

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily B member 14
Names
DnaJ (Hsp40) homolog, subfamily B, member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031723.4NP_001026893.1  dnaJ homolog subfamily B member 14 isoform 1

    See identical proteins and their annotated locations for NP_001026893.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC097460, AL121021, AP001962, AY358272, BC022248, DA854416
    Consensus CDS
    CCDS34035.1
    UniProtKB/Swiss-Prot
    Q8TBM8, Q9GZU9
    Related
    ENSP00000404381.2, ENST00000442697.7
    Conserved Domains (2) summary
    COG0484
    Location:107214
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam09320
    Location:271371
    DUF1977; Domain of unknown function (DUF1977)
  2. NM_001278310.2NP_001265239.1  dnaJ homolog subfamily B member 14 isoform 2

    See identical proteins and their annotated locations for NP_001265239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate upstream start codon. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC097460, AL121021, AL833412, AP001962, AY358272, DA854416
    UniProtKB/Swiss-Prot
    Q8TBM8
    Conserved Domains (2) summary
    COG0484
    Location:40147
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam09320
    Location:204304
    DUF1977; Domain of unknown function (DUF1977)
  3. NM_001278311.2NP_001265240.1  dnaJ homolog subfamily B member 14 isoform 3

    See identical proteins and their annotated locations for NP_001265240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains two alternate 3' exons, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC097460, BF307232, DA854416
    Consensus CDS
    CCDS75171.1
    UniProtKB/TrEMBL
    A0A087WWX2
    Related
    ENST00000471738.1
    Conserved Domains (1) summary
    TIGR03302
    Location:850
    OM_YfiO; outer membrane assembly lipoprotein YfiO

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    99896248..99946618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416185.1XP_047272141.1  dnaJ homolog subfamily B member 14 isoform X2

  2. XM_047416184.1XP_047272140.1  dnaJ homolog subfamily B member 14 isoform X1

    UniProtKB/TrEMBL
    A0A024RDI9
  3. XM_047416186.1XP_047272142.1  dnaJ homolog subfamily B member 14 isoform X3

    UniProtKB/TrEMBL
    A0A087WWX2
    Related
    ENSP00000480565.1, ENST00000610281.1

RNA

  1. XR_938772.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    103211731..103262102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024920.3: Suppressed sequence

    Description
    NM_024920.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.